Ovarian Cancer Screening in Women With a Family History of Breast or Ovarian Cancer

2006 ◽  
Vol 108 (5) ◽  
pp. 1176-1184 ◽  
Author(s):  
James V. Lacey ◽  
Mark H. Greene ◽  
Saundra S. Buys ◽  
Douglas Reding ◽  
Thomas L. Riley ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Screening ◽  
Family History ◽  
Ovarian Cancer Screening ◽  
History Of

scholarly journals No evidence of excessive cancer screening in female noncarriers from BRCA1/2 mutation–positive families

2017 ◽  
Vol 24 (6) ◽  
pp. 352 ◽  
Author(s):  
S. Guedaoura ◽  
S. Pelletier ◽  
W.D. Foulkes ◽  
P. Hamet ◽  
J. Simard ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ovarian Cancer ◽  
Cancer Screening ◽  
Family History ◽  
General Population ◽  
Resonance Imaging ◽  
Breast And Ovarian Cancer ◽  
Ovarian Cancer Screening ◽  
Breast Ultrasonography ◽  
Screening Practices

Background In families with a proven BRCA1/2 mutation, women not carrying the familial mutation should follow the cancer screening recommendations applying to women in the general population. In the present study, we evaluated the cancer screening practices of unaffected noncarriers from families with a proven BRCA mutation, and we assessed the role of family history in their screening practices.Methods Self-report data were provided retrospectively by 220 unaffected female noncarriers for periods of up to 10 years (mean: 4.3 years) since disclosure of their BRCA1/2 genetic test result. A ratio for the annual frequency of breast and ovarian cancer screening exams (mammography, breast ultrasonography, breast magnetic resonance imaging, transvaginal or pelvic ultrasound, cancer antigen 125 testing) was calculated as number of screening exams divided by the number of years in the individual observation period.Results The annual average for mammography exams was 0.15, 0.4, 0.56, and 0.71 in women 30–39, 40–49, 50–59, and 60–69 years of age respectively. The uptake of other breast and ovarian cancer screening exams was very low. Mammography and breast ultrasonography and magnetic resonance imaging were generally more frequent among participants with at least 1 first-degree relative affected by breast cancer.Conclusions In most noncarriers, screening practices are consistent with the guidelines concerning women in the general population. When noncarriers adopt screening behaviours that are different from those that would be expected for average-risk women, those behaviours are influenced by their familial cancer history.Impact Decision tools might help female noncarriers to be involved in their follow-up in accordance with their genetic status and their family history, while taking into account the benefits and disadvantages of cancer screening.

scholarly journals Motivators of Inappropriate Ovarian Cancer Screening: A Survey of Women and Their Clinicians

2020 ◽  
Author(s):  
Courtney Macdonald ◽  
Danielle Mazza ◽  
Martha Hickey ◽  
Morgan Hunter ◽  
Louise A Keogh ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Screening ◽  
Familial Breast Cancer ◽  
Social Role ◽  
Theoretical Domains Framework ◽  
Family Physicians ◽  
Environmental Context ◽  
Ovarian Cancer Screening ◽  
Peace Of Mind ◽  
Knowledge And Practice

Abstract Background This study examined why women and doctors screen for ovarian cancer (OC) contrary to guidelines. Methods Surveys, based on the Theoretical Domains Framework (TDF), were sent to women in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), and family physicians (FPs) and gynecologists who organised their screening. Results 832 of 1,264 (65.8%) kConFab women responded. 126 (15.1%) had screened in the last two years. Most of these (101, 80.2%) would continue even if their doctor told them it is ineffective. For women, key OC screening motivators operated in the domains of social role and goals (staying healthy for family, 93.9%), emotion and reinforcement (peace of mind, 93.1%) and beliefs about capabilities (tests are easy to have, 91.9%). 252 of 531 (47.5%) clinicians responded; a minority (FPs 45.8%, gynecologists 16.7%) thought OC screening was useful. For gynecologists, the main motivators of OC screening operated in the domains of environmental context (lack of other screening options, 27.6%), and emotion (patient peace of mind, 17.2%, difficulty discontinuing screening, 13.8%). For FPs, the strongest motivators were in the domains of social influence (women ask for these tests, 20.7%), goals (a chance these tests will detect cancer early, 16.4%), emotion (patient peace of mind, 13.8%) and environmental context (no other OC screening options, 11.2%). Conclusion Reasons for OC screening are mostly patient driven. Clinician knowledge and practice are discordant. Motivators of OC screening encompass several domains, which could be targeted in interventions to reduce inappropriate ovarian cancer screening.

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