scholarly journals 467: TIMELY ALBUMIN INFUSION MAY IMPROVE SURVIVAL IN CIRRHOTIC PATIENTS: A U.S. CROSS-SECTIONAL STUDY

2021 ◽  
Vol 50 (1) ◽  
pp. 224-224
Author(s):  
W. Ray Kim ◽  
Karthik. Raghunathan ◽  
Greg Martin ◽  
E. Anne Davis ◽  
Navreet Sindhwani ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Albumin Infusion ◽  
Cirrhotic Patients

scholarly journals Platelet count can predict the grade of esophageal varices in cirrhotic patients: a cross-sectional study

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 101
Author(s):  
Anum Afsar ◽  
Muhammad Nadeem ◽  
Syed Asim Ali Shah ◽  
Huma Hussain ◽  
Aysha Rani ◽  
...  
Keyword(s):  
Platelet Count ◽  
Negative Correlation ◽  
Esophageal Varices ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Variceal Hemorrhage ◽  
Sectional Study ◽  
Cross Sectional ◽  
Grade Ii ◽  
Cirrhotic Patients

Background: Bleeding from esophageal varices is a life-threatening complication in cirrhosis. Screening endoscopy is recommended in cirrhotic patients to identify patients at risk of variceal hemorrhage, but this is an invasive procedure and has limitations. Therefore, thrombocytopenia has been proposed to predict the existence and grade of esophageal varices. The aim of the current study was to determine a correlation between platelet count and grades of esophageal varices in patients with liver cirrhosis. Methods: This cross-sectional study was conducted at the POF Hospital, Wah Cantt from 1st October, 2017 to 30th May, 2018. Newly diagnosed cases of cirrhosis having varices of any grade on endoscopy were included. Endoscopic findings of patients were standardized using Paquet grading system. On the basis of platelet count, patients were divided into four subgroups. Platelet count groups were correlated with grading of esophageal varices using Spearman rank correlations. Chi Square test was used to see association between the platelet count and grade of esophageal varices. Results: 110 patients were included in the study, 55.5% (n=61) were male. Mean age of the patients was 59.89±9.01 years. Platelet count was <50,000/uL in 35.5% patients, 50,000-99,000/uL in 26.4%, 100,000-150000 in 12.7%, and >150,000/uL in 25.5% patients. Grade I esophageal varices were found in 23.6% of patients, whereas grade II, III and IV were found in 24.5%, 33.6% and 18.2% of patients, respectively. Mean platelet count was 213884.62/mm3 in patients with grade I varices, whereas it was 119518.52/mm3, 58386.49/mm3 and 21600.00/mm3 in patients with grade II, III and IV varices, respectively (p=<0.0001). A significant negative correlation between platelet count and grades of esophageal varices was found (p<0.001). Conclusion: Platelet count can predict the grade of esophageal varices in cirrhotic patients. There is significant negative correlation between platelet count and grades of esophageal varices.

scholarly journals Platelet count can predict the grade of esophageal varices in cirrhotic patients: a cross-sectional study

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 101
Author(s):  
Anum Afsar ◽  
Muhammad Nadeem ◽  
Syed Asim Ali Shah ◽  
Huma Hussain ◽  
Aysha Rani ◽  
...  
Keyword(s):  
Platelet Count ◽  
Negative Correlation ◽  
Esophageal Varices ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Variceal Hemorrhage ◽  
Sectional Study ◽  
Cross Sectional ◽  
Grade Ii ◽  
Cirrhotic Patients

Background: Bleeding from esophageal varices is a life-threatening complication in cirrhosis. Screening endoscopy is recommended in cirrhotic patients to identify patients at risk of variceal hemorrhage, but this is an invasive procedure and has limitations. Therefore, thrombocytopenia has been proposed to predict the existence and grade of esophageal varices. The aim of the current study was to determine a correlation between platelet count and grades of esophageal varices in patients with liver cirrhosis. Methods: This cross-sectional study was conducted at the POF Hospital, Wah Cantt from 1st October, 2017 to 30th May, 2018. Newly diagnosed cases of cirrhosis having varices of any grade on endoscopy were included. Endoscopic findings of patients were standardized using Paquet grading system. On the basis of platelet count, patients were divided into four subgroups. Platelet count groups were correlated with grading of esophageal varices using Spearman rank correlations. Chi Square test was used to see association between the platelet count and grade of esophageal varices. Results: 110 patients were included in the study, 55.5% (n=61) were male. Mean age of the patients was 59.89±9.01 years. Platelet count was <50,000/uL in 35.5% patients, 50,000-99,000/uL in 26.4%, 100,000-150000 in 12.7%, and >150,000/uL in 25.5% patients. Grade I esophageal varices were found in 23.6% of patients, whereas grade II, III and IV were found in 24.5%, 33.6% and 18.2% of patients, respectively. Mean platelet count was 213884.62/mm3 in patients with grade I varices, whereas it was 119518.52/mm3, 58386.49/mm3 and 21600.00/mm3 in patients with grade II, III and IV varices, respectively (p=<0.0001). A significant negative correlation between platelet count and grades of esophageal varices was found (p<0.001). Conclusion: Platelet count can predict the grade of esophageal varices in cirrhotic patients. There is significant negative correlation between platelet count and grades of esophageal varices.

scholarly journals Association between serum irisin concentrations and sarcopenia in patients with liver cirrhosis: a cross-sectional study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mingyuan Zhao ◽  
Xiaoshuang Zhou ◽  
Chengying Yuan ◽  
Rongshan Li ◽  
Yuehong Ma ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lumbar Vertebra ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Skeletal Muscle Index ◽  
Multivariable Regression ◽  
Cirrhotic Patients

Abstract Sarcopenia is an independent predictor of mortality in patients with liver cirrhosis. However, evidence has emerged that skeletal muscles mediate their protective effect against sarcopenia by secreting myokines. Therefore, we investigated whether irisin was associated with sarcopenia in patients with liver cirrhosis. This was an observational cross-sectional study of data collected from 187 cirrhotic patients. Sarcopenia was defined by computed tomography (CT) scans using specific cutoffs of the 3rd lumbar vertebra skeletal muscle index (L3 SMI). Morning irisin levels were obtained in all patients. Of the 187 patients, sarcopenia was noted in 73 (39%). Irisin concentrations were lower in sarcopenic patients (32.40 pg/ml [interquartile range (IQR): 18.70, 121.26], p < 0.001) than in nonsarcopenic patients. There was a weak correlation between L3 SMI and irisin levels (r = 0.516, p < 0.001). Multivariable regression analysis including L3 SMI, body mass index (BMI), very-low-density lipoprotein (VLDL)-cholesterol, aspartate aminotransferase (AST), adiponectin, and irisin levels showed that L3 SMI (odds ratio [OR] = 0.915, p = 0.023), adiponectin levels (OR = 1.074, p = 0.014), irisin levels (OR = 0.993, p < 0.001) and BMI (OR = 0.456, p = 0.004) were independently associated with sarcopenia. Irisin levels are associated with sarcopenia in patients with liver cirrhosis. This paper addresses a gap in the literature and facilitates the future transition into clinical treatment.

Tu1692 THE ASSOCIATION OF SARCOPENIA WITH MYOSTATIN, FOLLISTATIN AND IRISIN LEVELS IN CIRRHOTIC PATIENTS: A MULTICENTER CROSS-SECTIONAL STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1455
Author(s):  
Salih Boga ◽  
Abdullah E. Yildirim ◽  
Enver Ucbilek ◽  
Ali R. Koksal ◽  
Sevil Tokdemir Sisman ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cirrhotic Patients

The association of sarcopenia with myostatin, follistatin and irisin levels in cirrhotic patients: a multicenter cross-sectional study

2020 ◽  
Vol 73 ◽  
pp. S758-S759
Author(s):  
Salih Boga ◽  
Abdullah Emre Yıldırım ◽  
Enver Ucbilek ◽  
Ali Riza Koksal ◽  
Sevil Tokdemir Sisman ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cirrhotic Patients

scholarly journals Muscle depletion in cirrhotic patients assessed using computed tomography: a cross-sectional study

2020 ◽  
Vol 138 (2) ◽  
pp. 152-157
Author(s):  
Elisa Sfoggia Romagna ◽  
Marcelo Campos Appel-da-Silva ◽  
Eiji Suwa ◽  
Fabio Kunihiro Maeda ◽  
Angelo Alves de Mattos ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cirrhotic Patients

scholarly journals Spontaneous Bacterial Peritonitis and Short-Term Prognosis in a Group of Decompensated Cirrhotic Patients in Yaounde: A Cross-Sectional Study

2020 ◽  
Vol 10 (08) ◽  
pp. 203-213
Author(s):  
Mathurin Pierre Kowo ◽  
Sylvain Raoul Simeni Njonnou ◽  
Nelly Karelle Weyou Noubissi ◽  
Firmin Ankouane Andoulo ◽  
Gabin Ulrich Kenfack ◽  
...  
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Short Term ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients

scholarly journals Incidence of Cirrhotic Cardiomyopathy among Hundred Patients of Tamil Nadu, India- A Cross-sectional Study

2020 ◽  
Author(s):  
AK Koushik ◽  
P Ganesh ◽  
S Shanmuganathan
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Tamil Nadu ◽  
Troponin T ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Portosystemic Shunts ◽  
Cirrhotic Patients

Introduction: Cardiac dysfunction in cirrhosis may affect quality of life, prognosis and also may aggravate the course in patients undergoing invasive procedures such as surgery, insertion of a Transjugular Intrahepatic Portosystemic Shunts (TIPS), and liver transplantation. Aim: To evaluate the association of cardiomyopathy in cirrhotic patients of Tamil Nadu region in India. Materials and Methods: This cross-sectional study included 100 diagnosed cirrhotic patients. The patient’s cardiac status was obtained from Electrocardiography (ECG) and echocardiography. Liver profile was obtained from biochemical assays and ultrasonography of abdomen. The patients were classified as per cirrhosis grading system, Child Toucotte Pugh (CTP) scoring. The association was analysed using frequency analysis, percentage analysis and Chi-square test. Results: Prolonged QTc (>0.44 sec) was seen in 35% of the study population (p-value-0.014). A 10% of patients had systolic dysfunction and 25% showed diastolic dysfunction. Also, these patients showed positive troponin T and elevated Brain Natriuretic Peptide (BNP). The incidence of cardiomyopathy in cirrhotic patients was 28% in this study. Conclusion: This study established 28% incidence of cardiomyopathy in cirrhotic patients. This association may further be evaluated in larger study samples to provide a better prognosis and quality of life in cirrhotic patients treated with liver transplantation or other surgical procedures.

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