Central-Neck Dissection Debate Continues on Role of Prophylactic Surgery in Papillary Thyroid Cancer

2013 ◽  
Vol 35 ◽  
pp. 4-5
Author(s):  
Kurt Samson
Keyword(s):  
Thyroid Cancer ◽  
Neck Dissection ◽  
Papillary Thyroid Cancer ◽  
Central Neck Dissection ◽  
Prophylactic Surgery ◽  
Central Neck ◽  
Papillary Thyroid

scholarly journals Outcomes for patients with papillary thyroid cancer who do not undergo prophylactic central neck dissection

2015 ◽  
Vol 103 (3) ◽  
pp. 218-225 ◽  
Author(s):  
I. J. Nixon ◽  
L. Y. Wang ◽  
I. Ganly ◽  
S. G. Patel ◽  
L. G. Morris ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Neck Dissection ◽  
Papillary Thyroid Cancer ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Prophylactic Central Neck Dissection

scholarly journals Morbidity of central neck dissection for papillary thyroid cancer

Gland Surgery ◽  
2017 ◽  
Vol 6 (5) ◽  
pp. 492-500 ◽  
Author(s):  
Davide Lombardi ◽  
Remo Accorona ◽  
Alberto Paderno ◽  
Carlo Cappelli ◽  
Piero Nicolai
Keyword(s):  
Thyroid Cancer ◽  
Neck Dissection ◽  
Papillary Thyroid Cancer ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid

Prophylactic Central Neck Dissection and Local Recurrence in Papillary Thyroid Cancer: A Meta-analysis

2010 ◽  
Vol 17 (12) ◽  
pp. 3287-3293 ◽  
Author(s):  
Tarek Zetoune ◽  
Xavier Keutgen ◽  
Daniel Buitrago ◽  
Hasan Aldailami ◽  
Huibo Shao ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Local Recurrence ◽  
Neck Dissection ◽  
Papillary Thyroid Cancer ◽  
Meta Analysis ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Prophylactic Central Neck Dissection

scholarly journals Impact of lymph node metastases identified on central neck dissection (CND) on the recurrence of papillary thyroid cancer: potential role of BRAFV600E mutation in defining CND

2012 ◽  
Vol 20 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Ali S Alzahrani ◽  
Mingzhao Xing
Keyword(s):  
Thyroid Cancer ◽  
Neck Dissection ◽  
Papillary Thyroid Cancer ◽  
Tertiary Care ◽  
Disease Recurrence ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Cervical Lymph Nodes ◽  
The Impact

The impact of metastasized cervical lymph nodes (CLN) identified on central neck dissection (CND) on the recurrence/persistence of papillary thyroid cancer (PTC) and the extent of CND needed to reduce recurrence/persistence have not been firmly established. To assess the impact of CLN metastasis andBRAFmutation on the recurrence/persistence of PTC and the potential ofBRAFmutation in assisting CND. Analyses of 379 consecutive patients with PTC who underwent thyroidectomy with (n=243) or without CND (n=136) at a tertiary-care academic hospital during the period 2001–2010 for their clinicopathological outcomes andBRAFmutation status. Increasingly aggressive tumor characteristics were found as the extent of CND was advanced following conventional risk criteria from non-CND to limited CND to formal CND. Disease recurrence/persistence rate also sharply rose from 4.7% to 15.7% and 40.5% in these CND settings respectively (P<0.0001). CLN metastasis rate rose from 18.0 to 77.3% from limited CND to formal CND (P<0.0001). An increasing rate ofBRAFmutation was also found from less to more extensive CND. A strong association of CLN metastasis andBRAFmutation with disease recurrence/persistence was revealed on Kaplan–Meier analysis andBRAFmutation strongly predicted CLN metastasis. CLN metastases found on CND are closely associated with disease recurrence/persistence of PTC, which are both strongly predicted byBRAFmutation. Current selection of PTC patients for CND is appropriate but higher extent of the procedure, once selected, is needed to reduce disease recurrence, which may be defined by combination use of preoperativeBRAFmutation testing and conventional risk factors of PTC.

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