Differential Changes in Endothelin-1 and Endothelial Nitric Oxide Synthase Gene Expression in Rats with a Chronic High Pulmonary Flow

2004 ◽  
Vol 44 (Supplement 1) ◽  
pp. S341-S345
Author(s):  
Zen-Kong Dai ◽  
Mian-Shin Tan ◽  
Chee-Yin Chai ◽  
Ing-Jun Chen ◽  
Arco Y. Jeng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Endothelin 1 ◽  
Pulmonary Flow ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Estrogen Upregulates Endothelial Nitric Oxide Synthase Gene Expression in Fetal Pulmonary Artery Endothelium

1997 ◽  
Vol 81 (3) ◽  
pp. 355-362 ◽  
Author(s):  
Amy N. MacRitchie ◽  
Sandy S. Jun ◽  
Zhong Chen ◽  
Zohre German ◽  
Ivan S. Yuhanna ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Pulmonary Artery ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Expression of Endothelial Nitric Oxide Synthase and Endothelin-1 in Skin Tissue from Amputated Limbs of Patients with Complex Regional Pain Syndrome

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
J. George Groeneweg ◽  
Claudia Heijmans Antonissen ◽  
Frank J. P. M. Huygen ◽  
Freek J. Zijlstra
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Nitric Oxide Synthase ◽  
Complex Regional Pain Syndrome ◽  
Endothelial Nitric Oxide Synthase ◽  
Pain Syndrome ◽  
Skin Tissue ◽  
Endothelin 1 ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Background and Objectives. Impaired microcirculation during the chronic stage of complex regional pain syndrome (CRPS) is related to increased vasoconstriction, tissue hypoxia, and metabolic tissue acidosis in the affected limb. Endothelial dysfunction is suggested to be the main cause of diminished blood flow. The aim of this study was to examine the distribution of endothelial nitric oxide synthase (eNOS) and endothelin-1(ET-1) relative to vascular density represented by the endothelial marker CD31-immunoreactivity in the skin tissue of patients with chronic CRPS.Methods. We performed immunohistochemical staining on sections of skin specimens obtained from the amputated limbs (one arm and one leg) of two patients with CRPS.Results. In comparison to proximal specimens we found an increased number of migrated endothelial cells as well as an increase of eNOS activity in distal dermis specimens.Conclusions. We found indications that endothelial dysfunction plays a role in chronic CRPS.

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