T-005 ELEVATED BLOOD PRESSURE IS THE MAJOR DETERMINANT FOR INCREASED ARTERIAL STIFFNESS IN OBESE ADULTS

2011 ◽  
Vol 29 ◽  
pp. e52
Author(s):  
Thung-Lip Lee ◽  
Chin-Feng Hsuan ◽  
Ya-Feng Pan ◽  
Wei-Kung Tseng ◽  
Chih-Kun Huang ◽  
...  
Hypertension ◽  
2019 ◽  
Vol 73 (1) ◽  
pp. 229-234 ◽  
Author(s):  
Yang Liu ◽  
Yinkun Yan ◽  
Xiangjun Yang ◽  
Shengxu Li ◽  
Lydia Bazzano ◽  
...  

2015 ◽  
Vol 33 (2) ◽  
pp. 266-274 ◽  
Author(s):  
Miaoying Yun ◽  
Shengxu Li ◽  
Dianjianyi Sun ◽  
Shaoqing Ge ◽  
Chin-Chih Lai ◽  
...  

Hypertension ◽  
2017 ◽  
Vol 70 (3) ◽  
pp. 531-536 ◽  
Author(s):  
Heikki Aatola ◽  
Teemu Koivistoinen ◽  
Heikki Tuominen ◽  
Markus Juonala ◽  
Terho Lehtimäki ◽  
...  

2020 ◽  
Vol 33 (6) ◽  
pp. 563-569
Author(s):  
Alexei Wong ◽  
Arturo Figueroa ◽  
Stephen M Fischer ◽  
Reza Bagheri ◽  
Song-Young Park

Abstract BACKGROUND Effective nonpharmacological interventions targeting the enhancement of vascular function and decline of body fatness (BF) in obese individuals are indispensable for the prevention of hypertension and cardiovascular events in young adults. Mat Pilates training (MPT) has gained significant popularity worldwide, yet its effects on vascular function and body composition are understudied. We examined the effects of MPT on vascular function and BF in young obese women with elevated blood pressure (BP). METHODS Twenty-eight young obese women with elevated BP were randomized to an MPT (n = 14) or a nonexercising control (CON, n = 14) group for 12 weeks. Systemic arterial stiffness (brachial-ankle pulse wave velocity (baPWV)), brachial and aortic BP, wave reflection (augmentation index (AIx)), plasma nitric oxide (NO) levels, and BF percentage (BF%) were assessed before and after 12 weeks. RESULTS MPT significantly reduced (P ˂ 0.05) baPWV (−0.7 ± 0.2 m/s), AIx (−4 ± 1%), brachial systolic BP (−5 ± 1 mm Hg), aortic systolic BP (−6 ± 1 mm Hg), and BF% (−2 ± 1%), while significantly increasing plasma NO (6 ± 2 µM) (P ˂ 0.05) compared with CON. MPT improved systemic arterial stiffness, aortic BP, wave reflection, circulating plasma NO, and BF% in young obese women with elevated BP. CONCLUSIONS MPT may be an effective intervention for the improvement of vascular function and BF in young obese women with elevated BP, a population at risk for hypertension and early vascular complications. CLINICAL TRIALS REGISTRATION Trial Number NCT03907384.


1960 ◽  
Vol XXXIV (III) ◽  
pp. 411-429 ◽  
Author(s):  
Melvin J. Fregly ◽  
Kenneth M. Cook

ABSTRACT The anti-thyroid drugs, thiouracil, propylthiouracil, and methimazole, prevented both development of elevated blood pressure and cardiac hypertrophy usually accompanying kidney encapsulation with latex envelopes. These drugs also reduced elevated blood pressure of rats with hypertension of 13 to 40 weeks' duration prior to drug administration. Addition of desiccated thyroid powder to diet containing an anti-thyroid drug overcame the anti-hypertensive effect of the latter. Withdrawal of thyroid powder only was followed by return of blood pressure to previous low level within 3 weeks. The results suggest that the anti-hypertensive effect of these drugs is related directly to the hypothyroidism produced rather than to extrathyroidal effects of the drugs. Comparison of potencies of the 3 drugs in terms of anti-hypertensive effect, inhibition of growth rate, increase in testicular size, and increase in thyroid size suggests that propylthiouracil and methimazole are equally potent per unit weight of drug. Thiouracil has approximately half the potency of the other two.


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