Genetic Diversity of Enterovirus 71 Associated With Hand, Foot and Mouth Disease Epidemics in Japan from 1983 to 2003

2006 ◽  
Vol 25 (8) ◽  
pp. 691-694 ◽  
Author(s):  
Mitsuaki Hosoya ◽  
Yukihiko Kawasaki ◽  
Masatoki Sato ◽  
Ken Honzumi ◽  
Asako Kato ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Disease Epidemics

scholarly journals Enterovirus 71 from Fatal and Nonfatal Cases of Hand, Foot and Mouth Disease Epidemics in Malaysia, Japan and Taiwan in 1997-1998

1999 ◽  
Vol 52 (1) ◽  
pp. 12-15 ◽  
Author(s):  
Hiroyuki Shimizu ◽  
Andi Utama ◽  
Kumiko Yoshii ◽  
Hiromu Yoshida ◽  
Tetsuo Yoneyama ◽  
...  
Keyword(s):  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Disease Epidemics

scholarly journals Genetic Diversity of Coxsackievirus A16 Associated with Hand, Foot, and Mouth Disease Epidemics in Japan from 1983 to 2003

2006 ◽  
Vol 45 (1) ◽  
pp. 112-120 ◽  
Author(s):  
M. Hosoya ◽  
Y. Kawasaki ◽  
M. Sato ◽  
K. Honzumi ◽  
A. Hayashi ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackievirus A16 ◽  
Foot And Mouth ◽  
Disease Epidemics

Genetic diversity of enterovirus 71 isolated from cases of hand, foot and mouth disease in Yokohama City between 1982 and 2000

2003 ◽  
Vol 148 (2) ◽  
pp. 253-263 ◽  
Author(s):  
T. Munemura ◽  
M. Saikusa ◽  
C. Kawakami ◽  
H. Shimizu ◽  
M. Oseto ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71

2021 ◽  
Author(s):  
Ya-Ping Li ◽  
Mu-Qi Wang ◽  
Chen-Rui Liu ◽  
Hui-Ling Deng ◽  
Yuan Wu ◽  
...  
Keyword(s):  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals DNA methylation and SNP in IFITM3 are correlated with hand, foot and mouth disease caused by enterovirus 71

2021 ◽  
Vol 105 ◽  
pp. 199-208
Author(s):  
Mei Li ◽  
Ya-Ping Li ◽  
Hui-Ling Deng ◽  
Mu-Qi Wang ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease

2019 ◽  
Vol 20 (6) ◽  
pp. 1256 ◽  
Author(s):  
Mohd Anasir ◽  
Chit Poh
Keyword(s):  
Neutralizing Antibodies ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antigenic Peptide ◽  
Effective Vaccine ◽  
Inactivated Vaccine ◽  
Antigenic Peptides ◽  
Foot And Mouth ◽  
Etiological Agents

Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents, such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis for the design of future therapies against HFMD etiological agents.

scholarly journals Meteorological factors affect the hand, foot, and mouth disease epidemic in Qingdao, China, 2007–2014

2016 ◽  
Vol 144 (11) ◽  
pp. 2354-2362 ◽  
Author(s):  
F. C. JIANG ◽  
F. YANG ◽  
L. CHEN ◽  
J. JIA ◽  
Y. L. HAN ◽  
...  
Keyword(s):  
Meteorological Factors ◽  
Enterovirus 71 ◽  
Rank Correlation ◽  
Foot And Mouth Disease ◽  
Late Summer ◽  
Atmospheric Temperature ◽  
Early Spring ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Spearman Rank Correlation Analysis

SUMMARYHand, foot, and mouth disease (HFMD) has caused public health concerns worldwide. We aimed to investigate the effect of meteorological factors on the HFMD epidemic in Qingdao, a port city in China. A total of 78641 cases were reported in Qingdao between January 2007 and December 2014. Of those, 71084 (90·39%) occurred in children aged 0–5 years, with an incidence of 1691·2/100000. The incidence increased from early spring, peaked between spring and summer, and decreased in late summer. Aetiological agents in all severe cases and selected mild cases were characterized by examining throat swabs. Except for enterovirus 71 (EV71) and coxsackievirus A16 (CA16), other EVs caused >50% of the HFMD cases between 2011 and 2014. EV71 was more frequent in the off-peak months than in the peak months and prone to causing more severe cases compared to CA16 (χ2 = 46·3, P < 0·001). CA10 caused more severe HFMD than did CA6 (χ2 = 20·49, P < 0·001) and all non-CA10 EVs (χ2 = 41·01, P < 0·001). Community-derived HFMD cases accounted for 65·11%. Spearman rank correlation analysis showed that HFMD incidence in children aged 0–5 years was positively correlated with atmospheric temperature (rs = 0·77, P < 0·001), relative humidity (rs = 0·507, P < 0·001), and precipitation (rs = 0·328, P < 0·001). Climate changes and CA10 surveillance in communities should be integrated into the current prophylactic programme.

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