scholarly journals Meteorological factors affect the hand, foot, and mouth disease epidemic in Qingdao, China, 2007–2014

2016 ◽  
Vol 144 (11) ◽  
pp. 2354-2362 ◽  
Author(s):  
F. C. JIANG ◽  
F. YANG ◽  
L. CHEN ◽  
J. JIA ◽  
Y. L. HAN ◽  
...  
Keyword(s):  
Meteorological Factors ◽  
Enterovirus 71 ◽  
Rank Correlation ◽  
Foot And Mouth Disease ◽  
Late Summer ◽  
Atmospheric Temperature ◽  
Early Spring ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Spearman Rank Correlation Analysis

SUMMARYHand, foot, and mouth disease (HFMD) has caused public health concerns worldwide. We aimed to investigate the effect of meteorological factors on the HFMD epidemic in Qingdao, a port city in China. A total of 78641 cases were reported in Qingdao between January 2007 and December 2014. Of those, 71084 (90·39%) occurred in children aged 0–5 years, with an incidence of 1691·2/100000. The incidence increased from early spring, peaked between spring and summer, and decreased in late summer. Aetiological agents in all severe cases and selected mild cases were characterized by examining throat swabs. Except for enterovirus 71 (EV71) and coxsackievirus A16 (CA16), other EVs caused >50% of the HFMD cases between 2011 and 2014. EV71 was more frequent in the off-peak months than in the peak months and prone to causing more severe cases compared to CA16 (χ2 = 46·3, P < 0·001). CA10 caused more severe HFMD than did CA6 (χ2 = 20·49, P < 0·001) and all non-CA10 EVs (χ2 = 41·01, P < 0·001). Community-derived HFMD cases accounted for 65·11%. Spearman rank correlation analysis showed that HFMD incidence in children aged 0–5 years was positively correlated with atmospheric temperature (rs = 0·77, P < 0·001), relative humidity (rs = 0·507, P < 0·001), and precipitation (rs = 0·328, P < 0·001). Climate changes and CA10 surveillance in communities should be integrated into the current prophylactic programme.

scholarly journals DNA methylation and SNP in IFITM3 are correlated with hand, foot and mouth disease caused by enterovirus 71

2021 ◽  
Vol 105 ◽  
pp. 199-208
Author(s):  
Mei Li ◽  
Ya-Ping Li ◽  
Hui-Ling Deng ◽  
Mu-Qi Wang ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease

2019 ◽  
Vol 20 (6) ◽  
pp. 1256 ◽  
Author(s):  
Mohd Anasir ◽  
Chit Poh
Keyword(s):  
Neutralizing Antibodies ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antigenic Peptide ◽  
Effective Vaccine ◽  
Inactivated Vaccine ◽  
Antigenic Peptides ◽  
Foot And Mouth ◽  
Etiological Agents

Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents, such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis for the design of future therapies against HFMD etiological agents.

Prevalence of Coxsackievirus A6 and Enterovirus 71 in Hand, Foot and Mouth Disease in Nanjing, China in 2013

2015 ◽  
Vol 34 (9) ◽  
pp. 951-957 ◽  
Author(s):  
Ya-Qian Hu ◽  
Guang-Cheng Xie ◽  
Dan-Di Li ◽  
Li-Li Pang ◽  
Jing Xie ◽  
...  
Keyword(s):  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackievirus A6 ◽  
Foot And Mouth

scholarly journals Meteorological factors and its association with hand, foot and mouth disease in Southeast and East Asia areas: a meta-analysis

2018 ◽  
Vol 147 ◽  
Author(s):  
Chunxiao Duan ◽  
Xuefeng Zhang ◽  
Hui Jin ◽  
Xiaoqing Cheng ◽  
Donglei Wang ◽  
...  
Keyword(s):  
East Asia ◽  
Meteorological Factors ◽  
Global Climate ◽  
Meta Analysis ◽  
Foot And Mouth Disease ◽  
Correlation Coefficients ◽  
Mouth Disease ◽  
Asia Pacific ◽  
China National Knowledge Infrastructure ◽  
Foot And Mouth

AbstractSince the late 1990s, hand, foot and mouth disease (HFMD) has become a common health problem that mostly affects children and infants in Southeast and East Asia. Global climate change is considered to be one of the major risk factors for HFMD. This study aimed to assess the correlation between meteorological factors and HFMD in the Asia-Pacific region. PubMed, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang Data and Weipu Database were searched to identify relevant articles published before May 2018. Data were collected and analysed using R software. We searched 2397 articles and identified 51 eligible papers in this study. The present study included eight meteorological factors; mean temperature, mean highest temperature, mean lowest temperature, rainfall, relative humidity and hours of sunshine were positively correlated with HFMD, with correlation coefficients (CORs) of 0.52 (95% confidence interval (CI) 0.42–0.60), 0.43 (95% CI 0.23–0.59), 0.43 (95% CI 0.23–0.60), 0.27 (95% CI 0.19–0.35), 0.19 (95% CI 0.02–0.35) and 0.19 (95% CI 0.11–0.27), respectively. There were sufficient data to support a negative correlation between mean pressure and HFMD (COR = −0.51, 95% CI −0.63 to −0.36). There was no notable correlation with wind speed (COR = 0.10, 95% CI −0.03 to 0.23). Our findings suggest that meteorological factors affect the incidence of HFMD to a certain extent.

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