Impact of Pneumococcal Conjugate Vaccine and of Reduction of Antibiotic Use on Nasopharyngeal Carriage of Nonsusceptible Pneumococci in Children With Acute Otitis Media

2006 ◽  
Vol 25 (11) ◽  
pp. 1001-1007 ◽  
Author(s):  
Robert Cohen ◽  
Corinne Levy ◽  
France de La Rocque ◽  
Nathalie Gelbert ◽  
Alain Wollner ◽  
...  
Keyword(s):  
Otitis Media ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Acute Otitis Media ◽  
Antibiotic Use ◽  
Nasopharyngeal Carriage

Impact of 13-valent Pneumococcal Conjugate Vaccine on Pneumococcal Nasopharyngeal Carriage in Children With Acute Otitis Media

2012 ◽  
Vol 31 (3) ◽  
pp. 297-301 ◽  
Author(s):  
Robert Cohen ◽  
Corinne Levy ◽  
Edouard Bingen ◽  
Marc Koskas ◽  
Isabelle Nave ◽  
...  
Keyword(s):  
Otitis Media ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Acute Otitis Media ◽  
Nasopharyngeal Carriage

scholarly journals Epidemiology of Acute Otitis Media in Children After Introduction of the 13-Valent Pneumococcal Conjugate Vaccine

2018 ◽  
Vol 121 (7) ◽  
pp. 887-898
Author(s):  
Eriko Mokuno ◽  
Miyuki Morozumi ◽  
Kimiko Ubukata ◽  
Tsuyoshi Tajima ◽  
Satoshi Iwata
Keyword(s):  
Otitis Media ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Acute Otitis Media

scholarly journals The Burden of Pneumococcal Disease in the Canadian Population Before Routine Use of the Seven-Valent Pneumococcal Conjugate Vaccine

2007 ◽  
Vol 18 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Adrienne Morrow ◽  
Philippe De Wals ◽  
Geneviève Petit ◽  
Maryse Guay ◽  
Lonny James Erickson
Keyword(s):  
Otitis Media ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Disease ◽  
Acute Otitis Media ◽  
The United States ◽  
Canadian Population ◽  
Life Years ◽  
Life Years Lost ◽  
The Impact

BACKGROUND: In the United States, implementation of the seven-valent conjugate vaccine into childhood immunization schedules has had an effect on the burden of pneumococcal disease in all ages of the population. To evaluate the impact in Canada, it is essential to have an estimate of the burden of pneumococcal disease before routine use of the vaccine.METHODS: The incidence and costs of pneumococcal disease in the Canadian population in 2001 were estimated from various sources, including published studies, provincial databases and expert opinion.RESULTS: In 2001, there were 565,000 cases of pneumococcal disease in the Canadian population, with invasive infections representing 0.7%, pneumonia 7.5% and acute otitis media 91.8% of cases. There were a total of 3000 deaths, mainly as a result of pneumonia and largely attributable to the population aged 65 years or older. There were 54,330 life-years lost due to pneumococcal disease, and 37,430 quality-adjusted life-years lost due to acute disease, long-term sequelae and deaths. Societal costs were estimated to be $193 million (range $155 to $295 million), with 82% borne by the health system and 18% borne by families. Invasive pneumococcal infections represented 17% of the costs and noninvasive infections represented 83%, with approximately one-half of this proportion attributable to acute otitis media and myringotomy.CONCLUSIONS: The burden of pneumococcal disease before routine use of the pneumococcal conjugate vaccine was substantial in all age groups of the Canadian population. This estimate provides a baseline for further analysis of the direct and indirect impacts of the vaccine.

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