Vaccines Do Not Increase Risk of Multiple Sclerosis, Population Study Finds

2019 ◽  
Vol 19 (18) ◽  
pp. 9-10
Author(s):  
Eve Bender
Keyword(s):  
Multiple Sclerosis ◽  
Population Study ◽  
Increase Risk ◽  
Multiple Sclerosis Population

scholarly journals Impact of mass vaccination on SARS-CoV-2 infections among the total multiple sclerosis population receiving immunomodulatory disease-modifying therapies in England

2021 ◽  
Author(s):  
Nikos Evangelou ◽  
Afagh Garjani ◽  
Sameer Patel ◽  
Dhiren Bharkhada ◽  
Waqar Rashid ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
General Population ◽  
Mass Vaccination ◽  
Test Results ◽  
Health Security ◽  
Disease Modifying Therapies ◽  
Multiple Sclerosis Population ◽  
Impaired Immune Response ◽  
Disease Modifying ◽  
The Uk

Abstract This study aimed to understand changes in the risk of SARS-CoV-2 infection among all people with multiple sclerosis (MS) receiving immunomodulatory disease-modifying therapies (DMTs) in England, compared to the general population, following mass vaccination. Longitudinal data collected by the National Health Service (NHS) England on all MS DMT prescriptions and the UK Health Security Agency on all registered SARS-CoV-2 test results were analysed. The incidence rate ratio of SARS-CoV-2 infection among people with MS taking DMTs compared to the general population was calculated before (November 2020-January 2021) and after (July-August 2021) mass vaccination. Risk of SARS-CoV-2 infection among people on ocrelizumab or fingolimod compared to the general population increased following liberalisation of COVID-19 restrictions (during March-July 2021) despite mass vaccination. No changes were found with other DMTs. These findings converge with the impaired immune response to vaccines observed with ocrelizumab and fingolimod.

scholarly journals Reproductive history of the Danish multiple sclerosis population: A register-based study

2019 ◽  
Vol 26 (8) ◽  
pp. 902-911 ◽  
Author(s):  
Julie Yoon Moberg ◽  
Bjarne Laursen ◽  
Lau Caspar Thygesen ◽  
Melinda Magyari
Keyword(s):  
Multiple Sclerosis ◽  
Regression Model ◽  
Negative Binomial ◽  
Negative Binomial Regression ◽  
Annual Number ◽  
Negative Binomial Regression Model ◽  
Live Births ◽  
Multiple Sclerosis Population ◽  
History Of ◽  
Ectopic Pregnancies

Background: A diagnosis of multiple sclerosis (MS) may impact the choice of parenthood. Objective: To investigate the number of live births, abortions and ectopic pregnancies among persons with MS. Methods: From the Danish Multiple Sclerosis Registry, we extracted data from all persons diagnosed with MS from 1960 to 1996 and matched each MS person with four reference persons. We used a negative binomial regression model for the live births and Poisson regression model for abortions and ectopic pregnancies. The total fertility rate (TFR) during 1960–2016 and the annual number of live births in the MS population were analysed. Results: Persons with MS had fewer children than reference persons. Fewer women with MS had elective abortions after diagnosis (incidence rate ratio (IRR) = 0.88; 95% confidence interval (CI) = 0.78–1.00) than reference persons. There was no difference regarding the number of elective abortions, spontaneous abortions or ectopic pregnancies after onset. The TFR was lower for women with MS than for reference persons, and the number of annual live births by MS persons increased during 1960–2016. Conclusion: MS seems to considerably impact reproductive choices, especially after clinical diagnosis, resulting in the MS population having fewer children than the general population.

The prevalence of comorbidities in patients with multiple sclerosis: population-based registry data

2020 ◽  
Author(s):  
Gorica D. Maric ◽  
Tatjana D. Pekmezovic ◽  
Sarlota T. Mesaros ◽  
Olivera S. Tamas ◽  
Jovana B. Ivanovic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Population Based ◽  
Registry Data ◽  
Multiple Sclerosis Population ◽  
Population Based Registry

Does delay in acquiring childhood infection increase risk of multiple sclerosis?

1987 ◽  
Vol 8 (1) ◽  
pp. 23-28 ◽  
Author(s):  
M. Alter ◽  
Z. Zhen-xin ◽  
Z. Davanipour ◽  
E. Sobel ◽  
S. Min Lai ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Increase Risk ◽  
Childhood Infection

scholarly journals Effects of Fatigue on Balance and Mobility in Subjects with Multiple Sclerosis: A Brief Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Elisa Gervasoni ◽  
Davide Cattaneo ◽  
Angelo Montesano ◽  
Johanna Jonsdottir
Keyword(s):  
Multiple Sclerosis ◽  
Berg Balance Scale ◽  
Balance Performance ◽  
Before And After ◽  
Increase Risk ◽  
Risk Of Falls ◽  
Edss Score ◽  
The Difference ◽  
Dynamic Gait Index ◽  
Dynamic Gait

Purpose. People with Multiple Sclerosis (PwMS) tent to have increased levels of fatigue which can impact on their balance and increase risk of falls. However, the relationship between fatigue and balance is poorly understood. The aim of the present study was to assess if an experimentally induced fatigue had an immediate effect on balance. Methods. 37 inpatients with multiple sclerosis were recruited; the mean age (standard deviation) was 48.7 (9.6) years. The average onset of the pathology was 15.3 (9.8) years before the start of the study. The median (1°–3° quartile) Expanded Disability Status Scale (EDSS) score was 5.5 (4.5–6.0). Before and after a fatiguing treadmill, session, subjects were assessed with the Berg Balance Scale and Dynamic Gait Index. Results. After the treadmill, no statistically significant differences were found in balance before and after a treadmill session (monopodalic stance: before 5.3s (10.3) and after 7.7s (13.9); walk with horizontal head turns: before 11.6 (6.9) seconds and after 11.3 (7.7)). There was no correlation between the EDSS score and the difference in balance skills before and after treadmill. Conclusion. After treadmil PwMS were mentally and physically fatigued; however, their balance performance did not change, indicating no increase in risk of falling with fatigue.

Epidemiology of Anti-JCV Antibodies in Israeli Multiple Sclerosis Population (P02.138)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P02.138-P02.138
Author(s):  
A. Achiron ◽  
J. Chapman ◽  
M. Dolev ◽  
D. Magalashvili ◽  
Y. Stern ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Multiple Sclerosis Population
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