Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population

2000 ◽  
Vol 6 (2) ◽  
pp. 115-120 ◽  
Author(s):  
S.B. Patten ◽  
L.M. Metz ◽  
M.A. Reimer
Keyword(s):  
Multiple Sclerosis ◽  
Major Depression ◽  
Multiple Sclerosis Population

Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population

2000 ◽  
Vol 6 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Scott B Patten ◽  
Luanne M Metz ◽  
Marlene A Reimer
Keyword(s):  
Multiple Sclerosis ◽  
Major Depression ◽  
Depressive Disorders ◽  
Causal Effect ◽  
Composite International Diagnostic Interview ◽  
Population Based ◽  
Diagnostic Interview ◽  
Cross Sectional ◽  
Multiple Sclerosis Population ◽  
Additional Data Collection

The objective of this paper was to evaluate the lifetime and point prevalence of major depression in a population-based Multiple Sclerosis (MS) clinic sample, and to describe associations between selected biopsychosocial variables and the prevalence of lifetime major depression in this sample. Subjects who had participated in an earlier study were re-contacted for additional data collection. Eighty-three per cent (n=136) of those eligible consented to participate. Each subject completed the Composite International Diagnostic Interview (CIDI) and an interviewer-administered questionnaire evaluating a series of biopsychosocial variables. The lifetime prevalence of major depression in this sample was 22.8%, somewhat lower than previous estimates in MS clinic populations. Women, those under 35, and those with a family history of major depression had a higher prevalence. Also, subject reporting high levels of stress and heavy ingestion of caffeine (>400 mg) had a higher prevalence of major depression. As this was a cross-sectional analysis, the direction of causal effect for the observed associations could not be determined. By identifying variables that are associated with lifetime major depression, these data generate hypotheses for future prospective studies. Such studies will be needed to further understand the etiology of depressive disorders in MS.

Major depression in multiple sclerosis: A population-based perspective

Neurology ◽  
2003 ◽  
Vol 61 (11) ◽  
pp. 1524-1527 ◽  
Author(s):  
S. B. Patten ◽  
C. A. Beck ◽  
J. V.A. Williams ◽  
C. Barbui ◽  
L. M. Metz
Keyword(s):  
Multiple Sclerosis ◽  
Major Depression ◽  
Population Based

scholarly journals Impact of mass vaccination on SARS-CoV-2 infections among the total multiple sclerosis population receiving immunomodulatory disease-modifying therapies in England

2021 ◽  
Author(s):  
Nikos Evangelou ◽  
Afagh Garjani ◽  
Sameer Patel ◽  
Dhiren Bharkhada ◽  
Waqar Rashid ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
General Population ◽  
Mass Vaccination ◽  
Test Results ◽  
Health Security ◽  
Disease Modifying Therapies ◽  
Multiple Sclerosis Population ◽  
Impaired Immune Response ◽  
Disease Modifying ◽  
The Uk

Abstract This study aimed to understand changes in the risk of SARS-CoV-2 infection among all people with multiple sclerosis (MS) receiving immunomodulatory disease-modifying therapies (DMTs) in England, compared to the general population, following mass vaccination. Longitudinal data collected by the National Health Service (NHS) England on all MS DMT prescriptions and the UK Health Security Agency on all registered SARS-CoV-2 test results were analysed. The incidence rate ratio of SARS-CoV-2 infection among people with MS taking DMTs compared to the general population was calculated before (November 2020-January 2021) and after (July-August 2021) mass vaccination. Risk of SARS-CoV-2 infection among people on ocrelizumab or fingolimod compared to the general population increased following liberalisation of COVID-19 restrictions (during March-July 2021) despite mass vaccination. No changes were found with other DMTs. These findings converge with the impaired immune response to vaccines observed with ocrelizumab and fingolimod.

scholarly journals Reproductive history of the Danish multiple sclerosis population: A register-based study

2019 ◽  
Vol 26 (8) ◽  
pp. 902-911 ◽  
Author(s):  
Julie Yoon Moberg ◽  
Bjarne Laursen ◽  
Lau Caspar Thygesen ◽  
Melinda Magyari
Keyword(s):  
Multiple Sclerosis ◽  
Regression Model ◽  
Negative Binomial ◽  
Negative Binomial Regression ◽  
Annual Number ◽  
Negative Binomial Regression Model ◽  
Live Births ◽  
Multiple Sclerosis Population ◽  
History Of ◽  
Ectopic Pregnancies

Background: A diagnosis of multiple sclerosis (MS) may impact the choice of parenthood. Objective: To investigate the number of live births, abortions and ectopic pregnancies among persons with MS. Methods: From the Danish Multiple Sclerosis Registry, we extracted data from all persons diagnosed with MS from 1960 to 1996 and matched each MS person with four reference persons. We used a negative binomial regression model for the live births and Poisson regression model for abortions and ectopic pregnancies. The total fertility rate (TFR) during 1960–2016 and the annual number of live births in the MS population were analysed. Results: Persons with MS had fewer children than reference persons. Fewer women with MS had elective abortions after diagnosis (incidence rate ratio (IRR) = 0.88; 95% confidence interval (CI) = 0.78–1.00) than reference persons. There was no difference regarding the number of elective abortions, spontaneous abortions or ectopic pregnancies after onset. The TFR was lower for women with MS than for reference persons, and the number of annual live births by MS persons increased during 1960–2016. Conclusion: MS seems to considerably impact reproductive choices, especially after clinical diagnosis, resulting in the MS population having fewer children than the general population.

The prevalence of comorbidities in patients with multiple sclerosis: population-based registry data

2020 ◽  
Author(s):  
Gorica D. Maric ◽  
Tatjana D. Pekmezovic ◽  
Sarlota T. Mesaros ◽  
Olivera S. Tamas ◽  
Jovana B. Ivanovic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Population Based ◽  
Registry Data ◽  
Multiple Sclerosis Population ◽  
Population Based Registry

scholarly journals Screening for Major Depression in the Early Stages of Multiple Sclerosis

1995 ◽  
Vol 22 (3) ◽  
pp. 228-231 ◽  
Author(s):  
Michael J.L. Sullivan ◽  
Brian Weinshenker ◽  
Samuel Mikail ◽  
Scott R. Bishop
Keyword(s):  
Multiple Sclerosis ◽  
Major Depression ◽  
Clinical Utility ◽  
False Negative ◽  
False Negative Rate ◽  
Adjustment Disorder ◽  
Structured Interview ◽  
Newly Diagnosed ◽  
Predictive Values ◽  
Screening Measure

AbstractBackgroundMultiple Sclerosis (MS) is associated with a high risk of developing major depression, but depression in MS patients frequently goes undetected and untreated. The current study examined the clinical utility of the Beck Depression Inventory (BDI) as a screening measure for major depression in newly diagnosed MS patients.MethodsForty-six new referrals to an MS clinic completed the BDI and participated in a structured interview for major depression, within 2 months of the diagnosis of MS.ResultsAccording to DSM-III-R criteria, 40% of patients were diagnosed with major depression, 22% had adjustment disorder with depressed mood, and 37% showed no evidence of mood disorder. Sensitivity and specificity values, and positive and negative predictive values are reported for every BDI cut-off score between 9 and 21.ConclusionsA BDI cut-off score of 13 (sensitivity = .71, specificity = .79) is recommended as optimal for use in screening for major depression in newly diagnosed MS patients. The use of the BDI as a screening measure for major depression must proceed with caution given that a cut-off score of 13 still yielded a false-negative rate of 30%.

Perineuronal oligodendrocytes in health and disease: the journey so far

2019 ◽  
Vol 31 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Hans-Gert Bernstein ◽  
Gerburg Keilhoff ◽  
Henrik Dobrowolny ◽  
Paul C. Guest ◽  
Johann Steiner
Keyword(s):  
Multiple Sclerosis ◽  
Alzheimer’S Disease ◽  
Bipolar Disorder ◽  
Cerebral Ischemia ◽  
Major Depression ◽  
Gray Matter ◽  
Neuronal Firing ◽  
Close Proximity ◽  
Health And Disease ◽  
Experimental Demyelination

Abstract Perineuronal oligodendrocytes (pn-Ols) are located in the cerebral gray matter in close proximity to neuronal perikarya and less frequently near dendrites and neurites. Although their morphology is indistinguishable from that of other oligodendrocytes, it is not known if pn-Ols have a similar or different cell signature from that of typical myelinating oligodendroglial cells. In this review, we discussed the potential roles of these cells in myelination under normal and pathophysiologic conditions as functional and nutritional supporters of neurons, as restrainers of neuronal firing, and as possible players in glutamate-glutamine homeostasis. We also highlighted the occurrences in which perineuronal oligodendroglia are altered, such as in experimental demyelination, multiple sclerosis, cerebral ischemia, epilepsy, Alzheimer’s disease, schizophrenia, major depression, and bipolar disorder.

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