PET-CT scans can improve care for patients with cancer

e21149 Background: We previously reported that in mice models, tumor microenvironment is complex and intratumoral 18F-FDG distribution is heterogeneous. There were apparent spatial and temporal intratumoral 18F-FDG distribution changes occurring even within 24-48 hour interval in human cancer cell xenografts grown in nude mice. We hypothesized that what was documented in mice models may also be applicable to human patients with cancer. The objective of this study was to investigate the intratumoral spatial and temporal distribution of 18F-FDG in cancer patients. Methods: Five patients who had repeat PET/CT scans within 1-28 days and with no interval therapy were identified. All patients had fasted overnight and had blood glucose level of less than 200 mg/dl. They were injected with 8.0-14.0mCi of 18F-FDG intravenously, and whole body PET/CT scans were performed 60-80 minutes later utilizing a Siemens PET/CT scanner. Each patient’s intratumoral FDG activity distributions were mapped and compared to each other utilizing magnified digital images of the tumors. Results: Intratumoral FDG activity is very heterogeneous. Within the same tumor, there is a wide range of high and low FDG uptake variations. Apparent change in intratumoral FDG distribution was found within as short as a 24 hour interval in the same patient. Although the global tumoral FDG activity and liver FDG activity measured as SUVmaximum and SUVaverage were not significantly different from one PET/CT to another, there were significant spatial changes and variations of the tumor FDG activity between the two PET/CT images. Conclusions: Intratumoral 18F-FDG uptake is very heterogeneous and manifests both temporal and spatial changes within as short as 24 hours even in untreated cancer patients. This should be taken into consideration during FDG PET based therapy decisions, for example in tumor and nodal staging or radiation therapy planning.

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The Value of PET-CT Scans in Patients with Ventricular Assist Devices

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0036-1571747 ◽

2016 ◽

Vol 64 (S 01) ◽

Author(s):

A. Bernhardt ◽

M. Barten ◽

A. Schäfer ◽

B. Sill ◽

F. Wagner ◽

...

Keyword(s):

Ventricular Assist Devices ◽

Ct Scans ◽

Ventricular Assist ◽

Assist Devices ◽

Pet Ct

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Are outcomes of patients with advanced well-differentiated GEP-NETs on somatostatin analogues similar, irrespective of tracer uptake on 68gallium DOTA SSTR peptide PET CT scans?

Endocrine Abstracts ◽

10.1530/endoabs.72.p10 ◽

2020 ◽

Author(s):

Dinakshi Shah ◽

Oliver Loveland ◽

Amarjot Chander ◽

Tom Westwood ◽

Prakash Manoharan ◽

...

Keyword(s):

Somatostatin Analogues ◽

Tracer Uptake ◽

Ct Scans ◽

Pet Ct ◽

Well Differentiated

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Malignes Melanom

Onkologische Welt ◽

10.1055/a-1351-7165 ◽

2021 ◽

Vol 12 (01) ◽

pp. 48-48

Author(s):

Ine Schmale

Keyword(s):

Fdg Pet ◽

Malignes Melanom ◽

Ct Scans ◽

Pet Ct ◽

Fdg Pet Ct

In einer multizentrischen Studie wurde untersucht, ob mithilfe eines FDG-PET-CT-Scans die Entscheidung zum Beenden der Therapie mit Checkpoint-Inhibitoren möglicherweise verbessert werden kann.

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Outcomes of surgical treatment in patients with anorectal fistula cancer

Surgical Case Reports ◽

10.1186/s40792-021-01118-6 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Katsuya Osone ◽

Hiroomi Ogawa ◽

Chika Katayama ◽

Yuta Shibasaki ◽

Kunihiko Suga ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Mucinous Adenocarcinoma ◽

Fdg Pet ◽

R0 Resection ◽

Anorectal Fistula ◽

Patients With Cancer ◽

Pet Ct ◽

Fdg Pet Ct ◽

Fdg Accumulation

Abstract Background No standard treatment for anorectal fistula cancer, such as multidisciplinary therapy, has been established due to the rarity of the disease. Herein, we investigated patients with cancer associated with anorectal fistula who underwent surgery to clarify the clinicopathological characteristics and to propose future perspectives for treatment strategies. Case presentation Seven patients with cancer associated with anorectal fistula who underwent rectal amputation in our institute were analyzed with regard to clinical characteristics, pathological findings, surgical results, and prognosis. Four cases had Crohn's disease as an underlying cause. All seven cases were diagnosed as advanced stage. Preoperative [18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography/computed tomography (FDG-PET/CT) showed abnormal FDG accumulation in six cases including four mucinous adenocarcinomas. Three cases that received preoperative hyperthermo-chemoradiotherapy achieved pathological R0 resection. Postoperative recurrence was observed in four cases including three with Crohn's disease and one resulting in death. Conclusions Anorectal fistula cancer is rare and difficult to be diagnosed at early stages. Mucinous adenocarcinoma associated with anorectal fistula tends to exhibit abnormal FDG accumulation by FDG-PET/CT unlike common colorectal mucinous adenocarcinoma. Preoperative hyperthermo-chemoradiotherapy may be effective in obtaining pathological complete resection.

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Correction: Rijnsdorp et al. Impact of the Noise Penalty Factor on Quantification in Bayesian Penalized Likelihood (Q.Clear) Reconstructions of 68Ga-PSMA PET/CT Scans. Diagnostics 2021, 11, 847

Diagnostics ◽

10.3390/diagnostics11081371 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1371

Author(s):

Sjoerd Rijnsdorp ◽

Mark J. Roef ◽

Albert J. Arends

Keyword(s):

Penalized Likelihood ◽

Ct Scans ◽

Penalty Factor ◽

Psma Pet ◽

Pet Ct

In the original article [...]

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Benefit of Static FET PET in Pretreated Pediatric Brain Tumor Patients with Equivocal Conventional MRI Results

Klinische Pädiatrie ◽

10.1055/a-1335-4844 ◽

2021 ◽

Author(s):

Frederik Grosse ◽

Florian Wedel ◽

Ulrich-Wilhelm Thomale ◽

Ingo Steffen ◽

Arend Koch ◽

...

Keyword(s):

Brain Tumor ◽

Tumor Tissue ◽

Pediatric Brain Tumor ◽

Ct Scans ◽

Tumor Patients ◽

Fet Pet ◽

Conventional Mri ◽

Pet Ct ◽

Pediatric Brain

Abstract Background MRI has shortcomings in differentiation between tumor tissue and post-therapeutic changes in pretreated brain tumor patients. Patients We assessed 22 static FET-PET/CT-scans of 17 pediatric patients (median age 12 years, range 2–16 years, ependymoma n=4, medulloblastoma n=4, low-grade glioma n=6, high-grade glioma n=3, germ cell tumor n=1, choroid plexus tumor n=1, median follow-up: 112 months) with multimodal treatment. Method FET-PET/CT-scans were analyzed visually by 3 independent nuclear medicine physicians. Additionally quantitative FET-Uptake for each lesion was determined by calculating standardized uptake values (SUVmaxT/SUVmeanB, SUVmeanT/SUVmeanB). Histology or clinical follow-up served as reference. Results Static FET-PET/CT reliably distinguished between tumor tissue and post-therapeutic changes in 16 out of 17 patients. It identified correctly vital tumor tissue in 13 patients and post-therapeutic changes in 3 patients. SUV-based analyses were less sensitive than visual analyses. Except from a choroid plexus carcinoma, all tumor entities showed increased FET-uptake. Discussion Our study comprises a limited number of patients but results corroborate the ability of FET to detect different brain tumor entities in pediatric patients and discriminate between residual/recurrent tumor and post-therapeutic changes. Conclusions We observed a clear benefit from additional static FET-PET/CT-scans when conventional MRI identified equivocal lesions in pretreated pediatric brain tumor patients. These results warrant prospective studies that should include dynamic scans.

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Not All That Shines on a PET Scan Is Cancer: A Silicone-Induced Granuloma Masquerading as Malignancy

Clinics and Practice ◽

10.3390/clinpract11010003 ◽

2020 ◽

Vol 11 (1) ◽

pp. 8-12

Author(s):

Krishna Vedala ◽

Philip Sobash ◽

Deborah Johnson ◽

Krishna Kakkera

Keyword(s):

Pet Scan ◽

Imaging Modalities ◽

Ct Scans ◽

Pet Ct ◽

Suspicious Lesions

PET/CT scans are frequently used in the initial workup of suspicious lesions but not all that lights up on a PET is cancerous. We wish to discuss a case of silicone-induced granuloma mimicking malignancy and the role of other imaging modalities for further workup.

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