Influence of 8week therapy with Omeprazole on asthma symptoms, pulmonary function and quality of life in asthmatics with acid reflux symptoms

ABSTRACT CONTEXT AND OBJECTIVE: The combined effect of obesity and asthma may lead to significant impairment of quality of life (QOL). The aim here was to evaluate the prevalence of asthma among obese individuals, characterize the severity of impairment of quality of life and measure its relationship with pulmonary function. DESIGN AND SETTING: Observational cross-sectional study in public university hospital. METHODS: Morbidly obese individuals (body mass index > 40 kg/m2) seen in a bariatric surgery outpatient clinic and diagnosed with asthma, were included. Anthropometric data were collected, the Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) was applied and spirometry was performed. The subjects were divided into two groups based on the median of the score in the questionnaire (worse < 4 and better > 4) and were compared regarding anthropometric data and pulmonary function. RESULTS: Among the 4791 individuals evaluated, 219 were asthmatic; the prevalence of asthma was 4.57%. Of these, 91 individuals were called to start multidisciplinary follow-up during the study period, of whom 82 answered the questionnaire. The median score in the AQLQ(S) was 3.96 points and, thus, the individuals were classified as having moderate impairment of their overall QOL. When divided according to better or worse QOL, there was a statistically difference in forced expiratory flow (FEF) 25-75%, with higher values in the better QOL group. CONCLUSION: The prevalence of asthma was 4.57% and QOL was impaired among the asthmatic obese individuals. The worst QOL domain related to environmental stimuli and the best QOL domain to limitations of the activities. Worse QOL was correlated with poorer values for FEF 25-75%.

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A Study on Improvement of Pulmonary Function and Quality of Life in the Incentive Spirometer Breathing Exercise in the Elderly with Mild Cognitive Impairment

The Korean Health & Fundamental Medical Science Society ◽

10.37152/kmhs.2021.14.2.137 ◽

2021 ◽

Vol 14 (2) ◽

pp. 137-142

Author(s):

Gi-Do Kim

Keyword(s):

Quality Of Life ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Pulmonary Function ◽

The Elderly ◽

Breathing Exercise

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Health-related quality of life associates with clinical parameters in patients with NTM pulmonary disease

The International Journal of Tuberculosis and Lung Disease ◽

10.5588/ijtld.20.0790 ◽

2021 ◽

Vol 25 (4) ◽

pp. 299-304

Author(s):

K. Kawahara ◽

M. Tabusadani ◽

K. Yamane ◽

S. Takao ◽

Y. Kuroyama ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Pulmonary Disease ◽

Clinical Parameters ◽

Health Related Quality ◽

Cross Sectional ◽

Related Quality ◽

Health Related ◽

Radiological Score

BACKGROUND: Previous studies have shown a reduction in health-related quality of life (HRQoL) in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD). However, the causes of this decline and the factors that contribute to it are unknown. This study was conducted to analyse the association between the St George´s Respiratory Questionnaire (SGRQ) and clinical parameters, including age, disease duration, body composition, pulmonary function, chest X-ray findings, blood data and physical function.METHODS: We performed a single-centre, cross-sectional, retrospective study of 101 patients with NTM-PD from December 2016 to October 2019. The relationship between the SGRQ scores and clinical parameters was evaluated.RESULTS: The median patient age was 67.0 years. Pulmonary function, radiological score, albumin levels, C-reactive protein levels and incremental shuttle walk test distance (ISWD) were significantly correlated with the total and component scores on the SGRQ. Multiple regression analysis showed that the SGRQ score was significantly associated with radiological score, pulmonary function and ISWD.CONCLUSION: This study was the first to assess the effect of clinical parameters on the SGRQ in patients with NTM-PD. HRQoL as determined using the SGRQ was associated with the radiological score, pulmonary function and ISWD in patients with NTM-PD.

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Voice Disorders in Obstructive Sleep Apnea: Prevalence, Risk Factors, and the Role of CPAP

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489418819541 ◽

2018 ◽

Vol 128 (3) ◽

pp. 249-262 ◽

Cited By ~ 2

Author(s):

Nelson Roy ◽

Ray M. Merrill ◽

Jenny Pierce ◽

Krishna M. Sundar

Keyword(s):

Quality Of Life ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Voice Disorders ◽

Acid Reflux ◽

Voice Disorder ◽

Apnea Hypopnea Index ◽

Obstructive Sleep ◽

A Current

Objective: Obstructive sleep apnea (OSA) is characterized by frequent interruptions in breathing related to upper airway collapse during sleep and may adversely affect phonatory function. This study aimed to: (1) establish the prevalence, risks, and quality of life burden of voice disorders in OSA and (2) explore the relation between voice disorders and positive airway pressure (PAP) therapy. Study Design: Cross-sectional, descriptive epidemiology study. Methods: Analyses were based on 94 individuals with OSA (53 men, 41 women; mean age = 54.7 ± 12.8 years) who completed a telephone interview. Results: Twenty-eight percent of participants reported having a current voice disorder. Of those with a current voice disorder, 83% had experienced symptoms for at least a year, and 58% had symptoms for at least 4 years. The prevalence of a current voice disorder was greater in women than men (44% vs 15%, P = .0020) but did not vary significantly across different age groups, body mass index (BMI), apnea/hypopnea index (AHI) severity, or medical history. After adjusting for sex, consistent use of PAP therapy (with humidification) was associated with (1) lower occurrence of voice disorders in women (Mantel-Haenszel [MH] χ2 P = .0195), (2) reduced snoring severity accompanied by fewer voice disorders in men (MH χ2 P = .0101), and (3) fewer reports of acid reflux as a possible trigger for voice problems (MH χ2 P = .0226). Patients with OSA who also had a current voice disorder experienced lower overall quality of life compared to those without. Conclusions: Chronic, longstanding voice disorders are common in women with OSA and produce significant adverse effects on quality of life. Nightly PAP use (with humidification) was associated with fewer voice symptoms and reduced severity of snoring and acid reflux as possible contributors. Further research is necessary to better understand the origin of these voice disorders in OSA and their potential response to treatment.

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Relations between pulmonary function and quality of life following lung resection for lung cancer

Lung Cancer ◽

10.1016/s0169-5002(03)92771-1 ◽

2003 ◽

Vol 41 ◽

pp. S292

Author(s):

Satoshi Hara ◽

Takeshi Hirohata ◽

Yukihiko Hashimoto ◽

Hiroshi Otsuka ◽

Kenji Minami ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Pulmonary Function ◽

Lung Resection

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Novel Reconstruction Using Roux-en-Y Plus Antral Obstruction Following Proximal Gastrectomy: Feasibility and Quality of Life Benefits

10.21203/rs.2.11422/v1 ◽

2019 ◽

Author(s):

Dejun Yang ◽

Changming Wang ◽

Hongbing Fu ◽

Ziran Wei ◽

Xin Zhang ◽

...

Keyword(s):

Quality Of Life ◽

Reflux Esophagitis ◽

Proximal Gastrectomy ◽

Partial Gastrectomy ◽

Incidence Rates ◽

Reconstruction Method ◽

Reflux Symptoms ◽

Reconstruction Methods ◽

Postoperative Reflux

Abstract Background and Aims Routine gastroesophagostomy has been shown to have adverse effects on the recovery of digestive functions and quality of life because patients typically experience reflux symptoms after proximal gastrectomy. This study was performed to assess the feasibility and quality of life benefits of a novel reconstruction method termed Roux-en-Y anastomosis plus antral obstruction (RYAO) following proximal partial gastrectomy. Methods A total of 73 patients who underwent proximal gastrectomy from June 2015 to June 2017 were divided into two groups according to digestive reconstruction methods [RYAO (37 patients) and conventional esophagogastric anastomosis with pyloroplasty (EGPP, 36 patients)]. Clinical data were compared between the two groups retrospectively. Results The mean operative time for digestive reconstruction was slightly longer in the RYAO group than in the EGPP group. However, the incidence of postoperative short-term complications did not differ between the RYAO and the EGPP groups. At the 6-month follow-up, the incidence rates of both reflux esophagitis and gastritis were lower in the RYAO group than in the EGPP group (P = 0.002). Additionally, body weight recovery was better in the RYAO group (P = 0.028). The scale tests indicated that compared with the patients in the EGPP group, the patients in the RYAO group had significantly reduced reflux, nausea and vomiting and reported improvements in their overall health status and quality of life (all P < 0.05). Conclusion RYAO reconstruction may be a feasible procedure to reduce postoperative reflux symptoms and the incidence of reflux esophagitis and gastritis, thus improving patient quality of life after proximal gastrectomy.

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