scholarly journals Sevoflurane Remifentanil Interaction

2012 ◽  
Vol 116 (2) ◽  
pp. 311-323 ◽  
Author(s):  
Bjorn Heyse ◽  
Johannes H. Proost ◽  
Peter M. Schumacher ◽  
Thomas W. Bouillon ◽  
Hugo E. M. Vereecke ◽  
...  
Keyword(s):  
Laryngeal Mask Airway ◽  
Response Surface ◽  
Hierarchical Model ◽  
Laryngeal Mask ◽  
Surface Model ◽  
Laryngeal Mask Airway Insertion ◽  
Tetanic Stimulation ◽  
Response Surface Models ◽  
Drug Concentrations ◽  
Surface Models

Background Various pharmacodynamic response surface models have been developed to quantitatively describe the relationship between two or more drug concentrations with their combined clinical effect. We examined the interaction of remifentanil and sevoflurane on the probability of tolerance to shake and shout, tetanic stimulation, laryngeal mask airway insertion, and laryngoscopy in patients to compare the performance of five different response surface models. Methods Forty patients preoperatively received different combined concentrations of remifentanil (0-12 ng/ml) and sevoflurane (0.5-3.5 vol.%) according to a criss-cross design (160 concentration pairs, four per patient). After having reached pseudosteady state, the response to shake and shout, tetanic stimulation, laryngeal mask airway insertion, and laryngoscopy was recorded. For the analysis of the probability of tolerance, five different interaction models were tested: Greco, Reduced Greco, Minto, Scaled C50(O) Hierarchical, and Fixed C50(O) Hierarchical model. All calculations were performed with NONMEM VI (Icon Development Solutions, Ellicott City, MD). Results The pharmacodynamic interaction between sevoflurane and remifentanil was strongly synergistic for both the hypnotic and the analgesic components of anesthesia. The Greco model did not result in plausible parameter estimates. The Fixed C50(O) Hierarchical model performed slightly better than the Scaled C50(O) Hierarchical and Reduced Greco models, whereas the Minto model fitted less well. Conclusion We showed the importance of exploring various surface model approaches when studying drug interactions. The Fixed C50(O) Hierarchical model fits our data on sevoflurane remifentanil interaction best and appears to be an appropriate model for use in hypnotic-opioid drug interaction.

scholarly journals Response Surface Modeling of the Interaction between Propofol and Sevoflurane

2009 ◽  
Vol 111 (4) ◽  
pp. 790-804 ◽  
Author(s):  
Peter M. Schumacher ◽  
Jan Dossche ◽  
Eric P. Mortier ◽  
Martin Luginbuehl ◽  
Thomas W. Bouillon ◽  
...  
Keyword(s):  
Laryngeal Mask Airway ◽  
Response Surface ◽  
Bispectral Index ◽  
Receptor Activation ◽  
Laryngeal Mask ◽  
Laryngeal Mask Airway Insertion ◽  
Separate Analysis ◽  
Tetanic Stimulation ◽  
Gamma Aminobutyric Acid ◽  
Response Entropy

Background Propofol and sevoflurane display additivity for gamma-aminobutyric acid receptor activation, loss of consciousness, and tolerance of skin incision. Information about their interaction regarding electroencephalographic suppression is unavailable. This study examined this interaction as well as the interaction on the probability of tolerance of shake and shout and three noxious stimulations by using a response surface methodology. Methods Sixty patients preoperatively received different combined concentrations of propofol (0-12 microg/ml) and sevoflurane (0-3.5 vol.%) according to a crisscross design (274 concentration pairs, 3 to 6 per patient). After having reached pseudo-steady state, the authors recorded bispectral index, state and response entropy and the response to shake and shout, tetanic stimulation, laryngeal mask airway insertion, and laryngoscopy. For the analysis of the probability of tolerance by logistic regression, a Greco interaction model was used. For the separate analysis of bispectral index, state and response entropy suppression, a fractional Emax Greco model was used. All calculations were performed with NONMEM V (GloboMax LLC, Hanover, MD). Results Additivity was found for all endpoints, the Ce(50, PROP)/Ce(50, SEVO) for bispectral index suppression was 3.68 microg. ml(-1)/ 1.53 vol.%, for tolerance of shake and shout 2.34 microg . ml(-1)/ 1.03 vol.%, tetanic stimulation 5.34 microg . ml(-1)/ 2.11 vol.%, laryngeal mask airway insertion 5.92 microg. ml(-1) / 2.55 vol.%, and laryngoscopy 6.55 microg. ml(-1)/2.83 vol.%. Conclusion For both electroencephalographic suppression and tolerance to stimulation, the interaction of propofol and sevoflurane was identified as additive. The response surface data can be used for more rational dose finding in case of sequential and coadministration of propofol and sevoflurane.

A Method for Aerodynamic Characteristic Analysis of Hypersonic Aircraft Based on Response Surface Model

2013 ◽  
Vol 477-478 ◽  
pp. 277-280 ◽  
Author(s):  
Jie Yang ◽  
Song Ping Wu ◽  
Wen Xin Hou
Keyword(s):  
Flow Field ◽  
Response Surface ◽  
Aerodynamic Characteristic ◽  
Aerodynamic Characteristics ◽  
Surface Model ◽  
Complex Flow ◽  
Characteristic Analysis ◽  
Response Surface Models ◽  
Hypersonic Aircraft ◽  
Surface Models

Aerodynamic characteristic analysis of hypersonic cruise aircraft is more difficult than that of conventional aircraft, for the complex flow field simulation and inadequate amount of results under limited flight conditions. In this paper, numerical schemes applicable for hypersonic flow field are adopted to acquire a set of aerodynamic characteristics of a typical hypersonic cruise aircraft as sample data, based on which response surface models (RSM) are constructed to provide approximation of aerodynamic characteristics under any flight conditions within the design domain, finally the overall approximation performance of the response surface models are analyzed.

Cleaning and Bacteria Removal in Milking Systems by Alkaline Electrolyzed Oxidizing Water with Response Surface Design

2019 ◽  
Vol 62 (5) ◽  
pp. 1251-1258 ◽  
Author(s):  
Yu Liu ◽  
Chaoyuan Wang ◽  
Zhengxiang Shi ◽  
Baoming Li
Keyword(s):  
Water Treatment ◽  
Response Surface ◽  
Treatment Time ◽  
System Response ◽  
Surface Model ◽  
Response Surface Design ◽  
Surface Design ◽  
Response Surface Models ◽  
Surface Models ◽  
Bacteria Removal

Abstract. A wash cycle using an alkaline solution with a dissolved chemical detergent is a standard clean-in-place (CIP) process for cleaning milking systems. However, long-term chemical use may corrode equipment and create difficulties in wastewater treatment. This study investigated the potential for using alkaline electrolyzed oxidizing (EO) water as an alternative to alkaline chemical detergent for removal of microorganisms and adenosine triphosphate (ATP) on milking system materials. Laboratory trials were performed based on a Box-Behnken response surface design to assess the cleaning effect of alkaline EO water on three materials typically used in milking systems: stainless steel, rubber gasket, and polyvinyl chloride (PVC) hose. Results showed that alkaline EO water treatment was generally enhanced with increased treatment time, temperature, and pH, and their interaction effects were also observed in ATP removal. However, treatment time did not have a dominant role in cleaning PVC hose. Response surface models were developed to reliably predict detected microorganisms and relative light units (RLU) on the three materials after alkaline EO water treatment. Based on the response surface models, the three parameters for alkaline EO water cleaning were optimized as treatment time of 10.0 min, temperature of 61.8°C, and pH of 12, after which microorganisms and RLU were nearly undetectable. Alkaline EO water treatment with the optimized parameters had an equivalent or better cleaning ability compared to the commercial detergent, suggesting its potential as a cleaning and bacteria removal agent for milking systems. Keywords: Alkaline electrolyzed oxidizing water, Cleanliness, Milking system, Response surface model.

scholarly journals A LOCATION VALUE RESPONSE SURFACE MODEL FOR MASS APPRAISING: AN “ITERATIVE” LOCATION ADJUSTMENT FACTOR IN BARI, ITALY

2010 ◽  
Vol 14 (3) ◽  
pp. 231-244 ◽  
Author(s):  
Maurizio d’Amato
Keyword(s):  
Response Surface ◽  
Spatial Interpolation ◽  
Surface Model ◽  
Adjustment Factor ◽  
Specific Context ◽  
Response Surface Models ◽  
Surface Models ◽  
Adjustment Factors ◽  
Geostatistical Techniques ◽  
Location Adjustment

The work is focused on a new model of mass appraising including location variable. A location adjustment factor derived from a mathematical iteration was compared to the location adjustment factor based on geostatistical techniques. The work compares three different linear MRA models. The first one uses the location blind linear MRA. The second integrates the linear MRA with a location adjustment factor calculated using spatial interpolation. The second alternative is an application of Location Value Response Surface Models (O'Connor, 1982). It represents the first application of these models for mass appraising in Italy. The third approach introduces the Iterative Location Adjustment Factor. This is a factor which measure the influence of location derived from a mathematical iteration. Empirical results seem to prove the validity of Iterative Location Adjustment Factors in specific context with few observations. Santruka Darbe nagrinejamas naujas masinio turto vertinimo modelis, apimantis geografines padeties kintamaji. Iteraciniu būdu apskaičiuotas geografines padeties korekcijos veiksnys palygintas su geografines padeties korekcijos veiksniu, gautu taikant geostatistinius metodus. darbe lyginami trys skirtingi tiesiniai mrA modeliai. Pirmajame naudojamas geografines padeties nevertinantis tiesinis MRA. Antrajame tiesinis MRA sujungiamas su geografines padeties korekcijos veiksniu, apskaičiuotu pasitelkus erdvine interpoliacija. Antrojoje alternatyvoje pritaikomi geografines padeties vertes stebimojo paviršiaus (angl. Location Value Response Surface) modeliai (O'Connor 1982). Italijoje šie modeliai masiniam turto vertinimui naudojami pirma karta. Trečiojoje alternatyvoje taikomas iteracinis geografines padeties korekcijos veiksnys. Jis ivertina geografines padeties itaka, nustatyta iteraciniu būdu. Empiriniai rezultatai, regis, irodo iteraciniu geografines padeties korekcijos veiksniu pagristuma konkrečiame kontekste, kai stebejimu yra mažai.

Process Parameter Optimization for Machining SiCp/Al-MMC Using RSM and GA

2006 ◽  
Vol 326-328 ◽  
pp. 1213-1216
Author(s):  
Jae Seob Kwak ◽  
Long Zhu Chi ◽  
Yang Koo ◽  
Yeong Deug Jeong ◽  
Man Kyung Ha
Keyword(s):  
Genetic Algorithm ◽  
Response Surface ◽  
Metal Matrix ◽  
Response Surface Model ◽  
Surface Model ◽  
Matrix Composites ◽  
Grinding Forces ◽  
Response Surface Models ◽  
Grinding Parameters ◽  
Surface Models

This study aimed to achieve optimization of grinding parameters for aluminum-based metal matrix composites using response surface model and genetic algorithm. Experiments were conducted in accordance with a preplanned orthogonal array. The effect of grinding parameters on surface roughness and grinding forces was evaluated and second-order response surface models were developed for predicting grinding outcomes. Optimal grinding parameters were determined from the genetic algorithm and the response surface models.

Elemental chlorine-free bleaching of North American hardwood kraft pulps: Evaluation of oxidant-reinforced extraction variables on overall bleaching optimization

TAPPI Journal ◽  
2013 ◽  
Vol 12 (10) ◽  
pp. 33-41 ◽  
Author(s):  
BRIAN N. BROGDON
Keyword(s):  
Response Surface ◽  
Chlorine Dioxide ◽  
North American ◽  
Yield Loss ◽  
Alkaline Extraction ◽  
Kraft Pulps ◽  
Pulp Bleaching ◽  
Response Surface Models ◽  
Elemental Chlorine ◽  
Surface Models

This investigation evaluates how higher reaction temperatures or oxidant reinforcement of caustic extraction affects chlorine dioxide consumption during elemental chlorine-free bleaching of North American hardwood pulps. Bleaching data from the published literature were used to develop statistical response surface models for chlorine dioxide delignification and brightening sequences for a variety of hardwood pulps. The effects of higher (EO) temperature and of peroxide reinforcement were estimated from observations reported in the literature. The addition of peroxide to an (EO) stage roughly displaces 0.6 to 1.2 kg chlorine dioxide per kilogram peroxide used in elemental chlorine-free (ECF) bleach sequences. Increasing the (EO) temperature by Δ20°C (e.g., 70°C to 90°C) lowers the overall chlorine dioxide demand by 0.4 to 1.5 kg. Unlike what is observed for ECF softwood bleaching, the presented findings suggest that hot oxidant-reinforced extraction stages result in somewhat higher bleaching costs when compared to milder alkaline extraction stages for hardwoods. The substitution of an (EOP) in place of (EO) resulted in small changes to the overall bleaching cost. The models employed in this study did not take into account pulp bleaching shrinkage (yield loss), to simplify the calculations.

The median effective dose of dexmedetomidine for laryngeal mask airway insertion with propofol 2.0 mg/kg

2014 ◽  
Vol 58 (7) ◽  
pp. 815-819 ◽  
Author(s):  
H. J. KWAK ◽  
S. K. MIN ◽  
J. Y. YOO ◽  
K. H. PARK ◽  
J. Y. KIM
Keyword(s):  
Laryngeal Mask Airway ◽  
Effective Dose ◽  
Laryngeal Mask ◽  
Laryngeal Mask Airway Insertion
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