Effects of Traction on Structural Properties of Degenerated Disc Using an In Vivo Rat-Tail Model

Spine ◽  
2010 ◽  
Vol 35 (14) ◽  
pp. 1339-1345 ◽  
Author(s):  
Alon Lai ◽  
Daniel H. K. Chow
Keyword(s):  
Structural Properties ◽  
Rat Tail Model ◽  
Rat Tail

Reliability of radiographic intervertebral disc height measurement for in vivo rat-tail model

2007 ◽  
Vol 29 (7) ◽  
pp. 814-819 ◽  
Author(s):  
Alon Lai ◽  
Daniel H.K. Chow ◽  
W.S. Siu ◽  
Andrew D. Holmes ◽  
F.H. Tang
Keyword(s):  
Intervertebral Disc ◽  
Disc Height ◽  
Height Measurement ◽  
Intervertebral Disc Height ◽  
Rat Tail Model ◽  
Rat Tail

Effects of electroacupuncture on a degenerated intervertebral disc using an in-vivo rat-tail model

2008 ◽  
Vol 222 (2) ◽  
pp. 241-248 ◽  
Author(s):  
A Lai ◽  
D H K Chow ◽  
W-S Siu ◽  
A D Holmes ◽  
F-H Tang ◽  
...  
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Biological Properties ◽  
Disc Height ◽  
Static Compression ◽  
Intervertebral Disc Height ◽  
Rat Tail Model ◽  
Rat Tail

Electroacupuncture (EA) has long been used as conservative treatment for low back pain (LBP). Its effect on relief of back pain has been demonstrated in many clinical studies. However, whether it has any effect on the biological properties of an intervertebral disc, which is one of the major causes of LBP, is still unclear. The aim of this study was, therefore, to investigate the effects of EA with different simulation frequencies on an intervertebral disc with simulated degeneration using an in-vivo rat-tail model. In this study, 33 rats were used. Disc degeneration was simulated in the rat caudal 8—9 disc via continuous static compressive loading of 11 N for 2 weeks. EA with a frequency of 2 or 100 Hz was then applied to the degenerated disc for 3 weeks with 3 sessions/week and 20 min/session. The intervertebral disc height was measured before and after compression as well as after EA intervention for 3 weeks. The static compression was found to result in a reduction in the disc height of about 22 per cent. There was no evidence that this change could be reversed after resting or the EA intervention. However, EA at 100 Hz was found to induce a further decrease in disc height, which was not shown for the rats after resting or EA at 2 Hz. The results of this study showed that effects of EA on disc degeneration are frequency dependent and adverse effects could result if EA at a certain frequency was used.

scholarly journals In Vivo Implantation of Five Different Compositions of Tissue-Engineered Intervertebral Disks in a Rat Tail Model: Preliminary Results

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1319883-s-0032-1319883
Author(s):  
R. Härtl ◽  
M. Alimi ◽  
A. James ◽  
H. Gebhard ◽  
P. Grunert ◽  
...  
Keyword(s):  
Preliminary Results ◽  
Intervertebral Disks ◽  
Rat Tail Model ◽  
Rat Tail

scholarly journals Effects of Panax ginseng-containing herbal plasters on compressed intervertebral discs in an in vivo rat tail model

2013 ◽  
Vol 8 (1) ◽  
pp. 4 ◽  
Author(s):  
Daniel H K Chow ◽  
Alon Lai ◽  
Fuk-Hay Tang ◽  
Mason C P Leung
Keyword(s):  
Panax Ginseng ◽  
Intervertebral Discs ◽  
Rat Tail Model ◽  
Rat Tail

scholarly journals Effects of compressive loading on biomechanical properties of disc and peripheral tissue in a rat tail model

2009 ◽  
Vol 18 (11) ◽  
pp. 1595-1603 ◽  
Author(s):  
Tomokazu Nakamura ◽  
Takaro Iribe ◽  
Yoshinori Asou ◽  
Hiroo Miyairi ◽  
Kozo Ikegami ◽  
...  
Keyword(s):  
Compressive Loading ◽  
Biomechanical Properties ◽  
Peripheral Tissue ◽  
Rat Tail Model ◽  
Rat Tail

An Improved In Vivo Rat Tail Vertebra Model for the Study of Trabecular Bone Adaptation

1999 ◽  
Author(s):  
Mark J. Eichler ◽  
Chi Hyun Kim ◽  
X. Edward Guo
Keyword(s):  
Trabecular Bone ◽  
Large Scale ◽  
Bone Fractures ◽  
Mechanical Load ◽  
Bone Adaptation ◽  
Surgical Trauma ◽  
Micro Computed Tomography ◽  
Age Related ◽  
Rat Tail

Abstract The role of mechanical loading in trabecular bone adaptation is important for the understanding of bone integrity in different loading scenarios such as microgravity and for the etiology of age-related bone fractures. There have been numerous in vivo animal studies of bone adaptation, most of which are related to cortical bone remodeling, aimed at the investigation of Wolff’s Law [4], An interesting experimental model for trabecular bone adaptation has been developed in the rat tail vertebrae [2,3]. This model is attractive for trabecular bone adaptation studies because a controlled mechanical load can be applied to a whole vertebra with minimal surgical trauma, using a relatively inexpensive animal model. In addition, with advanced micro computed tomography (micro-CT) or micro magnetic resonance imaging (micro-MRI) coupled with large scale finite element modeling techniques, it is possible to characterize the three-dimensional (3D) stress/strain environment in the bone tissue close to a cellular level (∼25μm) [1]. Therefore, this in vivo rat tail model has a tremendous potential for quantification of the relationship between mechanical stimulation and biological response in trabecular bone adaptation.

scholarly journals Rouse model with transient intramolecular contacts on a timescale of seconds recapitulates folding and fluctuation of yeast chromosomes

2019 ◽  
Vol 47 (12) ◽  
pp. 6195-6207 ◽  
Author(s):  
Marius Socol ◽  
Renjie Wang ◽  
Daniel Jost ◽  
Pascal Carrivain ◽  
Cédric Vaillant ◽  
...  
Keyword(s):  
Structural Properties ◽  
Single Particle Tracking ◽  
Chemical Parameters ◽  
Chromosome Conformation ◽  
Formation Reaction ◽  
Rouse Model ◽  
Physico Chemical ◽  
Capture Techniques

Abstract DNA folding and dynamics along with major nuclear functions are determined by chromosome structural properties, which remain, thus far, elusive in vivo. Here, we combine polymer modeling and single particle tracking experiments to determine the physico-chemical parameters of chromatin in vitro and in living yeast. We find that the motion of reconstituted chromatin fibers can be recapitulated by the Rouse model using mechanical parameters of nucleosome arrays deduced from structural simulations. Conversely, we report that the Rouse model shows some inconsistencies to analyze the motion and structural properties inferred from yeast chromosomes determined with chromosome conformation capture techniques (specifically, Hi-C). We hence introduce the Rouse model with Transient Internal Contacts (RouseTIC), in which random association and dissociation occurs along the chromosome contour. The parametrization of this model by fitting motion and Hi-C data allows us to measure the kinetic parameters of the contact formation reaction. Chromosome contacts appear to be transient; associated to a lifetime of seconds and characterized by an attractive energy of –0.3 to –0.5 kBT. We suggest attributing this energy to the occurrence of histone tail-DNA contacts and notice that its amplitude sets chromosomes in ‘theta’ conditions, in which they are poised for compartmentalization and phase separation.

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