scholarly journals Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lijie Du ◽  
Lei Zhang ◽  
Junhong Zhao ◽  
Zixiu Chen ◽  
Xiang Liu ◽  
...  
Keyword(s):  
Eccrine Gland ◽  
Lumen Formation

scholarly journals Molecular Mechanisms Controlling Vascular Lumen Formation in Three-Dimensional Extracellular Matrices

2012 ◽  
Vol 195 (1-2) ◽  
pp. 122-143 ◽  
Author(s):  
Anastasia Sacharidou ◽  
Amber N. Stratman ◽  
George E. Davis
Keyword(s):  
Molecular Mechanisms ◽  
Three Dimensional ◽  
Extracellular Matrices ◽  
Lumen Formation ◽  
Vascular Lumen

β1Integrin Activation Inhibitsin VitroTube Formation: Effects on Cell Migration, Vacuole Coalescence and Lumen Formation

Endothelium ◽  
1999 ◽  
Vol 7 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Jennifer Gamble ◽  
Geoff Meyer ◽  
Leanne Noack ◽  
Jill Furze ◽  
Lisa Matthias ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lumen Formation

scholarly journals CD13 orients the apical-basal polarity axis necessary for lumen formation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Li-Ting Wang ◽  
Abira Rajah ◽  
Claire M. Brown ◽  
Luke McCaffrey
Keyword(s):  
Epithelial Cells ◽  
Apical Membrane ◽  
Initiation Site ◽  
Outer Cell ◽  
Cell Periphery ◽  
Complex Structures ◽  
Peptidase Activity ◽  
Epithelial Polarity ◽  
Lumen Formation ◽  
Apical Domain

AbstractPolarized epithelial cells can organize into complex structures with a characteristic central lumen. Lumen formation requires that cells coordinately orient their polarity axis so that the basolateral domain is on the outside and apical domain inside epithelial structures. Here we show that the transmembrane aminopeptidase, CD13, is a key determinant of epithelial polarity orientation. CD13 localizes to the apical membrane and associates with an apical complex with Par6. CD13-deficient cells display inverted polarity in which apical proteins are retained on the outer cell periphery and fail to accumulate at an intercellular apical initiation site. Here we show that CD13 is required to couple apical protein cargo to Rab11-endosomes and for capture of endosomes at the apical initiation site. This role in polarity utilizes the short intracellular domain but is independent of CD13 peptidase activity.

scholarly journals Vascular Lumen Formation: Negativity Will Tear Us Apart

2010 ◽  
Vol 20 (22) ◽  
pp. R973-R975 ◽  
Author(s):  
Renée M. Robbins ◽  
Greg J. Beitel
Keyword(s):  
Lumen Formation ◽  
Vascular Lumen
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