A regulatory perspective on the role of drug interactions in antiretroviral drug development

2008 ◽  
Vol 3 (3) ◽  
pp. 325-329 ◽  
Author(s):  
Kimberly A Struble ◽  
Kellie Schoolar Reynolds
Keyword(s):  
Drug Development ◽  
Drug Interactions ◽  
Antiretroviral Drug ◽  
Regulatory Perspective

The complexities of antiretroviral drug–drug interactions: role of ABC and SLC transporters

2010 ◽  
Vol 31 (1) ◽  
pp. 22-35 ◽  
Author(s):  
Olena Kis ◽  
Kevin Robillard ◽  
Gary N.Y. Chan ◽  
Reina Bendayan
Keyword(s):  
Drug Interactions ◽  
Slc Transporters ◽  
Antiretroviral Drug

943-P: Role of Model-Informed Drug Development in Confirming Additional Clinical Benefits of Dulaglutide

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 943-P
Author(s):  
LAI-SAN THAM ◽  
JEANNE GEISER ◽  
CHENG CAI TANG ◽  
KAREN SCHNECK ◽  
DAVID COX ◽  
...  
Keyword(s):  
Drug Development ◽  
Clinical Benefits

Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450

2016 ◽  
Vol 17 (7) ◽  
pp. 681-691 ◽  
Author(s):  
Ruirui Yang ◽  
Zhiqiang Luo ◽  
Yang Liu ◽  
Mohan Sun ◽  
Ling Zheng ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Cytochromes P450 ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Receptor ◽  
Receptor Blockers

scholarly journals Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Miao-Miao Zhao ◽  
Wei-Li Yang ◽  
Fang-Yuan Yang ◽  
Li Zhang ◽  
Wei-Jin Huang ◽  
...  
Keyword(s):  
Drug Development ◽  
Cathepsin L ◽  
Human Cells ◽  
New Drugs ◽  
Disease Course ◽  
Promising Target ◽  
First Time

AbstractTo discover new drugs to combat COVID-19, an understanding of the molecular basis of SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of cathepsin L (CTSL) in patients with COVID-19. The circulating level of CTSL was elevated after SARS-CoV-2 infection and was positively correlated with disease course and severity. Correspondingly, SARS-CoV-2 pseudovirus infection increased CTSL expression in human cells in vitro and human ACE2 transgenic mice in vivo, while CTSL overexpression, in turn, enhanced pseudovirus infection in human cells. CTSL functionally cleaved the SARS-CoV-2 spike protein and enhanced virus entry, as evidenced by CTSL overexpression and knockdown in vitro and application of CTSL inhibitor drugs in vivo. Furthermore, amantadine, a licensed anti-influenza drug, significantly inhibited CTSL activity after SARS-CoV-2 pseudovirus infection and prevented infection both in vitro and in vivo. Therefore, CTSL is a promising target for new anti-COVID-19 drug development.

scholarly journals The Role of Network Science in Glioblastoma

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1045
Author(s):  
Marta B. Lopes ◽  
Eduarda P. Martins ◽  
Susana Vinga ◽  
Bruno M. Costa
Keyword(s):  
Personalized Medicine ◽  
Drug Development ◽  
Information Flow ◽  
Clinical Studies ◽  
Network Science ◽  
Cancer Genomics ◽  
High Dimensional ◽  
Network Discovery ◽  
Software Implementations

Network science has long been recognized as a well-established discipline across many biological domains. In the particular case of cancer genomics, network discovery is challenged by the multitude of available high-dimensional heterogeneous views of data. Glioblastoma (GBM) is an example of such a complex and heterogeneous disease that can be tackled by network science. Identifying the architecture of molecular GBM networks is essential to understanding the information flow and better informing drug development and pre-clinical studies. Here, we review network-based strategies that have been used in the study of GBM, along with the available software implementations for reproducibility and further testing on newly coming datasets. Promising results have been obtained from both bulk and single-cell GBM data, placing network discovery at the forefront of developing a molecularly-informed-based personalized medicine.

Prevalence of drug–drug interactions in sarcoma patients: key role of the pharmacist integration for toxicity risk management

2021 ◽  
Author(s):  
Audrey Bellesoeur ◽  
Ithar Gataa ◽  
Anne Jouinot ◽  
Sarah El Mershati ◽  
Anne-Catherine Piketty ◽  
...  
Keyword(s):  
Risk Management ◽  
Drug Interactions ◽  
Toxicity Risk

Antiretroviral drug interactions

1995 ◽  
Vol 5 (2) ◽  
pp. 73-83 ◽  
Author(s):  
Edward P. Acosta ◽  
Courtney V. Fletcher
Keyword(s):  
Drug Interactions ◽  
Antiretroviral Drug
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