scholarly journals A simian immunodeficiency virus macaque model of highly active antiretroviral treatment: viral latency in the periphery and the central nervous system

2011 ◽  
Vol 6 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Janice E Clements ◽  
Lucio Gama ◽  
David R Graham ◽  
Joseph L Mankowski ◽  
MC Zink
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Antiretroviral Treatment ◽  
Viral Latency ◽  
Macaque Model ◽  
Highly Active ◽  
Highly Active Antiretroviral Treatment ◽  
Immunodeficiency Virus ◽  
The Central Nervous System

scholarly journals Early antiretroviral treatment prevents the development of central nervous system abnormalities in simian immunodeficiency virus-infected rhesus monkeys

AIDS ◽  
2009 ◽  
Vol 23 (10) ◽  
pp. 1187-1195 ◽  
Author(s):  
Maria Cecilia G Marcondes ◽  
Claudia Flynn ◽  
Salvador Huitron-Rezendiz ◽  
Debbie D Watry ◽  
Michelle Zandonatti ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Rhesus Monkeys ◽  
Antiretroviral Treatment ◽  
Immunodeficiency Virus ◽  
Early Antiretroviral Treatment

scholarly journals Intrathecal Humoral Responses Are Inversely Associated with the Frequency of Simian Immunodeficiency Virus Macrophage-Tropic Variants in the Central Nervous System

2009 ◽  
Vol 83 (16) ◽  
pp. 8282-8288 ◽  
Author(s):  
Elena Ryzhova ◽  
Pyone Aye ◽  
Tom Harvey ◽  
Wei Cao ◽  
Andrew Lackner ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Humoral Response ◽  
Temporal Course ◽  
Immunodeficiency Virus ◽  
Siv Infection ◽  
The Central Nervous System ◽  
Humoral Responses

ABSTRACT Sustained simian immunodeficiency virus (SIV) infection of the central nervous system (CNS) depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. The CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response, in general, to control M-tropic strains. We investigated the temporal course of the intrathecal fusion inhibitory activity against an M-tropic viral variant and found an inverse relationship between the magnitude of this neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.

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