Is Patient-reported Penicillin Allergy Independently Associated with Increased Risk of Prosthetic Joint Infection After Total Joint Arthroplasty of the Hip, Knee, and Shoulder?

Objective: The current review was designed to assess the impact of prior intra-articular injections on the risk of prosthetic joint infection (PJI) in patients undergoing total joint arthroplasty (TJA) with a focus on the timing of injection before surgery.Methods: The databases of PubMed, Embase and Google Scholar were searched up to 15th June 2021. All studies comparing the incidence of PJI with and without prior intra-articular injections were included. Risk ratios (RR) with 95% confidence intervals were calculated for PJI.Results: Nineteen studies were included. Both corticosteroids and hyaluronic acid injections were used before TJA in the included studies. Overall, comparing 127,163 patients with prior intra-articular injections and 394,104 patients without any injections, we noted a statistically significant increased risk of PJI in the injection group (RR 1.24 95% CI: 1.11, 1.38 I2 = 48% p = 0.002). On subgroup analysis, there was a statistically significant increased risk of PJI in the injection group in studies where intra-articular injections were administered <12 months before surgery (RR 1.18 95% CI: 1.10, 1.27 I2 = 7% p < 0.00001). Furthermore, on meta-analysis, we noted non-significant but increased risk of PJI when injections were administered 1 month (RR 1.47 95% CI: 0.88, 2.46 I2 = 77% p = 0.14), 0–3 months (RR 1.22 95% CI: 0.96, 1.56 I2 = 84% p = 0.11), and 3–6 months (RR 1.16 95% CI: 0.99, 1.35 I2 = 49% p = 0.06) before surgery.Conclusion: Our results indicate that patients with prior intra-articular injections have a small but statistically significant increased risk of PJI after TJA. Considering that PJI is a catastrophic complication with huge financial burden, morbidity and mortality; the clinical significance of this small risk cannot be dismissed. The question of the timing of injections and the risk of PJI still remains and can have a significant impact on the decision making.Systematic Review Registration: PROSPERO: CRD42021258297.

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Early prosthetic joint infection after primary total joint arthroplasty: risk factors and treatment strategies

10.33612/diss.97641504 ◽

2019 ◽

Author(s):

Claudia Aline Maria Löwik

Keyword(s):

Risk Factors ◽

Prosthetic Joint Infection ◽

Total Joint Arthroplasty ◽

Joint Infection ◽

Treatment Strategies ◽

Joint Arthroplasty ◽

Prosthetic Joint

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Osteoprotegerin gene polymorphism is not associated with prosthetic joint infection after total joint arthroplasty in the Czech population

Biomedical Papers ◽

10.5507/bp.2012.024 ◽

2014 ◽

Vol 158 (2) ◽

pp. 273-276 ◽

Cited By ~ 1

Author(s):

Zdenka Navratilova ◽

Jiri Gallo ◽

Matej Smizansky ◽

Frantisek Mrazek ◽

Martin Petrek

Keyword(s):

Gene Polymorphism ◽

Prosthetic Joint Infection ◽

Total Joint Arthroplasty ◽

Joint Infection ◽

Joint Arthroplasty ◽

Czech Population ◽

Prosthetic Joint ◽

Osteoprotegerin Gene

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Are current DRG-based bundled payment models for revision total joint arthroplasty risk-adjusting adequately?

The Bone & Joint Journal ◽

10.1302/0301-620x.102b7.bjj-2019-1641.r1 ◽

2020 ◽

Vol 102-B (7) ◽

pp. 959-964

Author(s):

Azeem T. Malik ◽

Mengnai Li ◽

Safdar N. Khan ◽

John H. Alexander ◽

Daniel Li ◽

...

Keyword(s):

Prosthetic Joint Infection ◽

Total Joint Arthroplasty ◽

Marginal Cost ◽

Joint Infection ◽

Joint Arthroplasty ◽

Bundled Payment ◽

Bundled Payments ◽

Prosthetic Joint ◽

Revision Total Joint Arthroplasty ◽

Payment Models

Aims Currently, the US Center for Medicaid and Medicare Services (CMS) has been testing bundled payments for revision total joint arthroplasty (TJA) through the Bundled Payment for Care Improvement (BPCI) programme. Under the BPCI, bundled payments for revision TJAs are defined on the basis of diagnosis-related groups (DRGs). However, these DRG-based bundled payment models may not be adequate to account appropriately for the varying case-complexity seen in revision TJAs. Methods The 2008-2014 Medicare 5% Standard Analytical Files (SAF5) were used to identify patients undergoing revision TJA under DRG codes 466, 467, or 468. Generalized linear regression models were built to assess the independent marginal cost-impact of patient, procedural, and geographic characteristics on 90-day costs. Results A total of 9,263 patients (DRG-466 = 838, DRG-467 = 4,573, and DRG-468 = 3,842) undergoing revision TJA from 2008 to 2014 were included in the study. Undergoing revision for a dislocation (+$1,221), periprosthetic fracture (+$4,454), and prosthetic joint infection (+$5,268) were associated with higher 90-day costs. Among comorbidities, malnutrition (+$10,927), chronic liver disease (+$3,894), congestive heart failure (+$3,292), anaemia (+$3,149), and coagulopathy (+$2,997) had the highest marginal cost-increase. The five US states with the highest 90-day costs were Alaska (+$14,751), Maryland (+$13,343), New York (+$7,428), Nevada (+$6,775), and California (+$6,731). Conclusion Under the proposed DRG-based bundled payment methodology, surgeons would be reimbursed the same amount of money for revision TJAs, regardless of the indication (periprosthetic fracture, prosthetic joint infection, mechanical loosening) and/or patient complexity. Cite this article: Bone Joint J 2020;102-B(7):959–964.

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Intraoperative Transfusion of Red Blood Cell Units Stored >14 Days is Associated with an Increased Risk of Prosthetic Joint Infection

Journal of Bone and Joint Infection ◽

10.7150/jbji.30001 ◽

2019 ◽

Vol 4 (2) ◽

pp. 85-91

Author(s):

Eduard Tornero ◽

Arturo Pereira ◽

Misericordia Basora ◽

Luis Lozano ◽

Laura Morata ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Prosthetic Joint Infection ◽

Critical Period ◽

Joint Infection ◽

Joint Arthroplasty ◽

Prosthetic Joint ◽

Increased Risk ◽

Independent Variable ◽

Design And Methods

Abstract. Background: The aim of the present study was to evaluate the association between prosthetic joint infection (PJI) after joint arthroplasty and the length of red blood cell (RBC) storage, timing of RBC transfusion, and the number of RBC units transfused.Study design and Methods: All patients who underwent a primary or revision joint artrhoplasty between January 2000 and December 2012 were retrospectively reviewed. For this study, only patients who received RBC transfusions during the day of the surgery (early transfusion group) or within the first 4 days after surgery (late transfusion group) were included.Results: A total of 9906 patients were reviewed. In the early transfusion group (n=1153, 11.6%), patients receiving 1 or 2 RBC units (3.5% vs 6.3%, P=0.041), 3 or 4 RBC (1.3% vs 13.3%, P=0.004) or ≥5 RBC units (5.0% vs 37.5%, P=0.026) had a higher PJI rate only when >50% of RBC units transfused had been stored >14 days. In the late transfusion group (n=920, 9.3%) these differences were not significant. Early transfusion of RBCs stored >14 days was an independent variable associated with an increased risk of PJI (OR:2.50, 95%CI:1.44-4.33)Conclusion: Transfusion of RBC within the first 6h after joint arthroplasty was an independent variable associated with PJI risk when RBC units are stored >14 days. The rate of PJI increased with the number of old RBC units transfused within this critical period.

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