Significance of Cyclooxygenase 2, EZH-2 Polycomb Group and p53 Expression in Actinic Keratosis and Squamous Cell Carcinomas of the Skin

2013 ◽  
Vol 35 (4) ◽  
pp. 425-431 ◽  
Author(s):  
Anna-Maria Athanassiadou ◽  
Andreas C. Lazaris ◽  
Efstratios Patsouris ◽  
Angelos Tsipis ◽  
George Chelidonis ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Actinic Keratosis ◽  
Squamous Cell Carcinomas ◽  
Cyclooxygenase 2 ◽  
Polycomb Group ◽  
P53 Expression

Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression

2000 ◽  
Vol 29 (4) ◽  
pp. 167-172 ◽  
Author(s):  
King Y. Lam ◽  
Irene O. L. Ng ◽  
Anthony P. W. Yuen ◽  
Dora L. W. Kwong ◽  
William Wei
Keyword(s):  
Cyclin D1 ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Expression ◽  
Oral Squamous Cell Carcinomas

Linear porokeratosis with multiple squamous cell carcinomas: sludy of p53 expression in porokeratosis and squamous cell carcinoma

1996 ◽  
Vol 134 (6) ◽  
pp. 1151-1153 ◽  
Author(s):  
S. Sasaki ◽  
Y. Urano ◽  
K. Nakagawa ◽  
H. Nagae ◽  
H. Nakanishi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Expression

Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status

2008 ◽  
Vol 61 (9) ◽  
pp. 1034-1037 ◽  
Author(s):  
S Aulmann ◽  
J Schleibaum ◽  
R Penzel ◽  
P Schirmacher ◽  
G Gebauer ◽  
...  
Keyword(s):  
Squamous Cell ◽  
P53 Protein ◽  
In Situ Hybridisation ◽  
Intraepithelial Neoplasia ◽  
Squamous Cell Carcinomas ◽  
Invasive Squamous Cell Carcinoma ◽  
Fluorescence In Situ Hybridisation ◽  
P53 Expression ◽  
Usual Type ◽  
Hpv Status

Aims:Two different forms of vulvar intraepithelial neoplasia (VIN) are recognised: (1) usual-type (bowenoid) VIN, which is related to high-risk papillomavirus infection, and (2) differentiated (simplex) VIN, which is associated with chronic inflammation. The aim of this study was to investigate the presence of chromosome 3q26 gains in the spectrum of precancerous lesions and invasive squamous cell carcinomas (SCCs) of the vulva.Methods:3q26 gains were analysed using fluorescence in situ hybridisation in a series of usual-type VINs, VINs of the differentiated type and invasive squamous cell carcinomas. In addition, all cases were examined for human papillomavirus (HPV) DNA, p53 mutations, and p16 and p53 protein expression.Results:Gains of chromosome 3q26 were present in all VINs of the differentiated type and in 50% of the usual-type VIN lesions. 81% of SCCs were positive for 3q26 gains irrespective of the HPV status and of the associated precursor lesion. HPV-associated lesions exhibited the typical, strong cytoplasmic p16 accumulation while mutated p53 was only detected in HPV-negative VINs or SCCs, and was associated with an overexpression of p53 protein.Conclusions:Immunohistochemical evaluation of p16 and p53 expression aids in the differential diagnosis of squamous cell alterations of the vulva. However, detection of 3q26 imbalance is of additional diagnostic value in difficult cases of HPV-unrelated usual-type VINs and VINs of the differentiated type.

scholarly journals Expression and clinical implication of cyclooxygenase-2 and E-cadherin in oral squamous cell carcinomas

2020 ◽  
Vol 21 (8) ◽  
pp. 667-674 ◽  
Author(s):  
Angela Santoro ◽  
Pantaleo Bufo ◽  
Giuseppe Russo ◽  
Simona Cagiano ◽  
Silvana Papagerakis ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Clinical Implication ◽  
Squamous Cell Carcinomas ◽  
Cyclooxygenase 2 ◽  
Oral Squamous Cell Carcinomas ◽  
E Cadherin

Significance of p53 expression in non-tumoral epithelium adjacent to oral squamous cell carcinomas

2002 ◽  
Vol 116 (05) ◽  
Author(s):  
Miguel Angel Gonzalez-Moles ◽  
Pablo Galindo ◽  
Jose Gutierrez ◽  
Alberto Rodriguez-Archilla ◽  
Isabel Ruiz-Avila ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Expression ◽  
Oral Squamous Cell Carcinomas

scholarly journals Actinic Keratosis: A New Approach to the Treatment / Aktinična Keratoza: Novi Pristup Lečenju

2009 ◽  
Vol 1 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Đorđije Karadaglić ◽  
Marina Jovanović
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Actinic Keratosis ◽  
Squamous Cell Carcinomas ◽  
Molecular Characteristics ◽  
Solar Ultraviolet Radiation ◽  
New Approach ◽  
Atypical Keratinocytes ◽  
Surrounding Skin

Abstract Actinic keratosis is an intraepidermal proliferation of transformed, atypical keratinocytes, induced by exposure to solar ultraviolet radiation. Many authors believe that it is the earliest form of squamous cell carcinoma. More than 40% of all metastatic squamous cell carcinomas develop from actinic keratosis. The clinical, histological and molecular characteristics of actinic keratosis are those of squamous cell carcinomas. Since it can be extremely hard to distinguish actinic keratosis from some squamous cell carcinomas, treatment can be rather difficult. The best treatment of actinic keratosis is its prevention. The main reason for therapy which is universally accepted, is prevention of squamous cell carcinoma. A number of options are available, but when considering the efficacy, invasive procedures remain the standard treatment. Treatment of individual lesions may prevent further progression of actinic damage present in the surrounding skin

Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas

Pathology ◽  
2007 ◽  
Vol 39 (6) ◽  
pp. 545-550 ◽  
Author(s):  
Nam-Pyo Cho ◽  
Hye-Suk Han ◽  
Yunjo Soh ◽  
Kyung-Yeol Lee ◽  
Son Hyun-Jin
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Cyclooxygenase 2 ◽  
Over Expression

Molecular Pathology and Clinicopathologic Features of Penile Tumors

1999 ◽  
Vol 123 (10) ◽  
pp. 895-904 ◽  
Author(s):  
King Y. Lam ◽  
Kwok W. Chan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Squamous Cell Carcinomas ◽  
Squamous Differentiation ◽  
P53 Expression ◽  
Paget Disease ◽  
Basaloid Squamous

Abstract Objectives.—To examine the histologic features of p21 in penile tumors and to determine the role of p21 and p53 in the pathogenesis of this group of tumors. Methods.—The clinicopathologic features of 87 patients with penile tumors were studied. The expression of p53 and p21 proteins in 49 cases was investigated by immunohistochemistry. Results.—Of the 87 tumors studied, 84 represented primary penile tumors (72 malignant and 12 benign) and 3 represented secondary tumors (2 from bladder, 1 from nasopharynx). The primary malignant penile tumors included 66 surface carcinomas with squamous differentiation (92%), 3 cases of Paget disease (4%), 1 case of Bowen disease (1%), and 2 penile urethral squamous cell carcinomas (3%). The former group was subdivided into squamous cell carcinoma (n = 50), verrucous carcinoma (n = 8), basaloid squamous cell carcinoma (n = 3), adenoid squamous cell carcinoma (n = 3), spindle cell carcinoma (n = 1), and adenosquamous carcinoma (n = 1). The benign tumors were squamous cell papillomas (n = 10) and fibromatoses (n = 2). Expression of p21 and p53 was noted in 40% and 89%, respectively, of the 47 patients with primary surface penile carcinoma with squamous differentiation. Positive p21 and p53 expression was also seen in 2 cases of Paget disease. Staining for p21 was often weak and was found in the suprabasal region of carcinomas with squamous differentiation, while p53 expression was seen in the basal region of squamous cell carcinomas. Preinvasive lesions also showed p21 and p53 expression. An inverse correlation between p53 and p21 expression (p53+/p21− or p53−/p21+) was noted in half of the squamous cell carcinomas, 4 of 5 verrucous carcinomas, 2 of 3 basaloid squamous cell carcinomas, and in 1 spindle cell carcinoma. The other cases did not show this correlation. Conclusions.—Penile tumors had different histologic variants and p21/p53 expression patterns. Expression of p21 did play a role in some tumors and could be dependent or independent of p53 expression.

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