Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice

2017 ◽  
Vol 35 (4) ◽  
pp. 810-821 ◽  
Author(s):  
Chunfen Mo ◽  
Ming Yang ◽  
Xiaojuan Han ◽  
Junhong Li ◽  
Guangping Gao ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Fat Mass ◽  
Lipid Accumulation ◽  
Foam Cells ◽  
Macrophage Foam Cells ◽  
Deficient Mice

scholarly journals βCommon Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Tzong-Shyuan Lee ◽  
Kuo-Yun Lu ◽  
Yuan-Bin Yu ◽  
Hsueh-Te Lee ◽  
Feng-Chuan Tsai
Keyword(s):  
Lipid Accumulation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Neutralizing Antibody ◽  
Foam Cells ◽  
Beneficial Effects ◽  
Inflammatory Protein ◽  
Common Receptor ◽  
Macrophage Foam Cells ◽  
Key Factor

Erythropoietin (EPO), the key factor for erythropoiesis, also protects macrophage foam cells from lipid accumulation, yet the definitive mechanisms are not fully understood.βcommon receptor (βCR) plays a crucial role in the nonhematopoietic effects of EPO. In the current study, we investigated the role ofβCR in EPO-mediated protection in macrophages against oxidized low-density lipoprotein- (oxLDL-) induced deregulation of lipid metabolism and inflammation. Here, we show thatβCR expression was mainly in foamy macrophages of atherosclerotic aortas from apolipoprotein E-deficient mice. Results of confocal microscopy and immunoprecipitation analyses revealed thatβCR was colocalized and interacted with EPO receptor (EPOR) in macrophages. Inhibition ofβCR activation by neutralizing antibody or small interfering RNA (siRNA) abolished the EPO-conferred protection in oxLDL-induced lipid accumulation. Furthermore, EPO-promoted cholesterol efflux and upregulation of ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 were prevented by pretreatment withβCR neutralizing antibody orβCR siRNA. Additionally, blockage ofβCR abrogated the EPO-conferred anti-inflammatory action on oxLDL-induced production of macrophage inflammatory protein-2. Collectively, our findings suggest thatβCR may play an important role in the beneficial effects of EPO against oxLDL-elicited dysfunction of macrophage foam cells.

Transduction of star decreases lipid accumulation and atherosclerotic lesions in apolipoprotein e-deficient mice

2007 ◽  
Vol 42 (6) ◽  
pp. S223
Author(s):  
Yanxia Ning ◽  
Leyuan Xu ◽  
Yifeng Jiang ◽  
Chen Xu ◽  
Chao Lu ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Lipid Accumulation ◽  
Atherosclerotic Lesions ◽  
Deficient Mice

scholarly journals Adiponectin reduces lipid accumulation in macrophage foam cells

2009 ◽  
Vol 202 (1) ◽  
pp. 152-161 ◽  
Author(s):  
Ling Tian ◽  
Nanlan Luo ◽  
Richard L. Klein ◽  
B. Hong Chung ◽  
W. Timothy Garvey ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Foam Cells ◽  
Macrophage Foam Cells

Hypoxia‐inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E–deficient mice

2017 ◽  
Vol 31 (11) ◽  
pp. 4971-4984 ◽  
Author(s):  
Anja Maier ◽  
Hao Wu ◽  
Nada Cordasic ◽  
Peter Oefner ◽  
Barbara Dietel ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Neutral Lipid ◽  
Lipid Accumulation ◽  
Inducible Protein ◽  
Deficient Mice

PM2.5 aggravates the lipid accumulation, mitochondrial damage and apoptosis in macrophage foam cells

2019 ◽  
Vol 249 ◽  
pp. 482-490 ◽  
Author(s):  
Jiangyan Liu ◽  
Shuang Liang ◽  
Zhou Du ◽  
Jingyi Zhang ◽  
Baiyang Sun ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Foam Cells ◽  
Mitochondrial Damage ◽  
Macrophage Foam Cells

scholarly journals MicroRNA sequences modulating inflammation and lipid accumulation in macrophage “foam” cells: Implications for atherosclerosis

2020 ◽  
Vol 12 (7) ◽  
pp. 303-333
Author(s):  
Richard James Lightbody ◽  
Janice Marie Walsh Taylor ◽  
Yvonne Dempsie ◽  
Annette Graham
Keyword(s):  
Lipid Accumulation ◽  
Foam Cells ◽  
Macrophage Foam Cells
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