Determinants of pulse wave velocity trajectories from youth to young adulthood

AbstractIncreased arterial stiffness measured by pulse wave velocity (PWV) is an important parameter in the assessment of cardiovascular risk. Our previous longitudinal study has demonstrated that carotid-distal PWV showed reasonable stability throughout youth and young adulthood. This stability might be driven by genetic factors that are expressed consistently over time. We aimed to illustrate the relative contributions of genetic and environmental factors to the stability of carotid-distal PWV from youth to young adulthood. We also examined potential ethnic differences. For this purpose, carotid-distal PWV was measured twice in 497 European American (EA) and African American (AA) twins, with an average interval time of 3 years. Twin modelling on PWV showed that heritability decreased over time (62–35%), with the nonshared environmental influences becoming larger. There was no correlation between the nonshared environmental factors on PWV measured at visit 1 and visit 2, with the phenotypic tracking correlation (r = 0.32) completely explained by shared genetic factors over time. Novel genetic influences were identified accounting for a significant part of the variance (19%) at the second measurement occasion. There was no evidence for ethnic differences. In summary, novel genetic effects appear during development into young adulthood and account for a considerable part of the variation in PWV. Environmental influences become larger with age for PWV.

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LONGITUDINAL ASSOCIATIONS OF FAT MASS, LEAN MASS, BODY MASS INDEX AND BLOOD PRESSURE FROM CHILDHOOD THROUGH YOUNG ADULTHOOD WITH CAROTID-FEMORAL PULSE WAVE VELOCITY AND CAROTID INTIMA-MEDIA THICKNESS AT AGE 24.5 YEARS

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(21)02848-5 ◽

2021 ◽

Vol 77 (18) ◽

pp. 1490

Author(s):

Andrew O. Agbaje ◽

Alan R. Barker ◽

Tomi-Pekka Tuomainen

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Young Adulthood ◽

Lean Mass ◽

Pulse Wave ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Longitudinal Associations

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2.5 IN SINGLETONS BORN AT TERM, LOWER GESTATIONAL AGE IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY IN YOUNG ADULTHOOD: THE NORTHERN IRELAND YOUNG HEARTS PROJECT (NIYHP)

Artery Research ◽

10.1016/j.artres.2015.10.012 ◽

2015 ◽

Vol 12 (C) ◽

pp. 42

Author(s):

Isabel Ferreira* ◽

Alison Gallagher ◽

Liam Murray ◽

Colin Boreham

Keyword(s):

Northern Ireland ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Young Adulthood ◽

Gestational Age ◽

Pulse Wave ◽

Aortic Pulse Wave Velocity

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M.555 Assessing pulse wave velocity and biophysical properties of the aorta in patients with end-stage renal disease

Atherosclerosis ◽

10.1016/s0021-9150(04)90553-9 ◽

2004 ◽

Vol 5 (1) ◽

pp. 128-129

Author(s):

D KARAKITSOS

Keyword(s):

Pulse Wave Velocity ◽

Renal Disease ◽

Wave Velocity ◽

End Stage Renal Disease ◽

Pulse Wave ◽

Biophysical Properties ◽

Stage Renal Disease ◽

End Stage

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M.572 Invasive measurements of pulse wave velocity correlate with the degree of echocardiographic aortic valve calcification and its severity in aged patients with degenerative aortic valve stenosis

Atherosclerosis ◽

10.1016/s0021-9150(04)90570-9 ◽

2004 ◽

Vol 5 (1) ◽

pp. 132-133 ◽

Cited By ~ 1

Author(s):

P LIU

Keyword(s):

Aortic Valve ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Aortic Valve Stenosis ◽

Pulse Wave ◽

Aortic Valve Calcification ◽

Aged Patients ◽

Valve Calcification

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Pulse wave velocity rather than atherosclerotic markers describe vascular status of patients with type 2 diabetes mellitus

10.1055/s-0038-1641893 ◽

2018 ◽

Author(s):

B Stratmann ◽

M Rydzkowski ◽

D Tschöpe

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Vascular Status

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Augmentation Index und Pulse Wave Velocity in Schwangerschaften mit Präeklampsie oder Gestationsdiabetes

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-2007-1002846 ◽

2007 ◽

Vol 211 (S 2) ◽

Author(s):

B Schiessl ◽

M Burgmann ◽

V Sauer ◽

A Neubauer ◽

F Kainer ◽

...

Keyword(s):

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Augmentation Index

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STRUCTURAL AND FUNCTIONAL VASCULAR CHANGES IN HIGH NORMAL ARTERIAL PRESSURE

BULGARIAN JOURNAL OF VETERINARY MEDICINE ◽

10.15547//tjs.2020.01.002 ◽

2020 ◽

Vol 23 (1) ◽

pp. 7-11

Author(s):

P. Nikolov

Keyword(s):

Arterial Pressure ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Pressure ◽

Pulse Wave ◽

Augmentation Index ◽

Aortic Pressure ◽

Large Arteries ◽

Central Aortic Pressure ◽

Significant Difference

The PURPUSE of the present study is changes in function and structure of large arteries in individuals with High Normal Arterial Pressure (HNAP) to be established. MATERIAL and METHODS: Structural and functional changes in the large arteries were investigated in 80 individuals with HNAP and in 45 with optimal arterial pressure (OAP). In terms of arterial stiffness, pulse wave velocity (PWV), augmentation index (AI), central aortic pressure (CAP), pulse pressure (PP) were followed up in HNAP group. Intima media thickness (IMT), flow-induced vasodilatation (FMD), ankle-brachial index (ABI) were also studied. RESULTS: Significantly increased values of pulse wave velocity, augmentation index, central aortic pressure, pulse pressure are reported in the HNAP group. In terms of IMT and ABI, being in the reference interval, there is no significant difference between HNAP and OAP groups. The calculated cardiovascular risk (CVR) in both groups is low. CONCLUSION: Significantly higher values of pulse wave velocity, augmentation index, central aortic pressure and pulse pressure in the HNAP group are reported.

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