Gender-specific association between the kininogen 1 gene variants and essential hypertension in Chinese Han population

2009 ◽  
Vol 27 (3) ◽  
pp. 484-490 ◽  
Author(s):  
Weiyan Zhao ◽  
Yaping Wang ◽  
Laiyuan Wang ◽  
Xiangfeng Lu ◽  
Wei Yang ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Chinese Han Population ◽  
Gene Variants ◽  
Chinese Han ◽  
Han Population ◽  
Specific Association ◽  
Gender Specific

G Protein β3 Subunit Gene Variants and Essential Hypertension in the Northern Chinese Han Population

2005 ◽  
Vol 69 (4) ◽  
pp. 468-473 ◽  
Author(s):  
Biao Li ◽  
Dongliang Ge ◽  
Yuelan Wang ◽  
Weiyan Zhao ◽  
Xiaoyang Zhou ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
G Protein ◽  
Chinese Han Population ◽  
Gene Variants ◽  
Subunit Gene ◽  
Chinese Han ◽  
Han Population ◽  
Northern Chinese

scholarly journals Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Jin Li ◽  
Jing Hu ◽  
Rong Sun ◽  
Yongpan Zhao ◽  
Heping Liu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Protective Factor ◽  
Secondary Hypertension ◽  
Chinese Han Population ◽  
Genotype Distribution ◽  
Chinese Han ◽  
Data Set ◽  
Han Population ◽  
Significant Difference ◽  
Cullin 3

Background. Hypertension, including essential and secondary hypertension, is a multifactorial disease, affecting more than one billion people worldwide. Secondary hypertension can result from mutations of cullin-3 (CUL3); however, whether polymorphisms ofCUL3are associated with essential hypertension (EH) has not been reported. Here, we investigated the association betweenCUL3SNPs rs17479770 and rs3738952 and EH in the Chinese Han population.Methods. This case-control study investigated 520 representatives, including 259 patients with EH and 261 normotensive controls matched for age, gender, BMI, TG, TC, and HbA1c for the distribution of functional rs17479770 and rs3738952 within theCUL3gene by using PCR and RFLP.Results. Our results showed that there was no significant difference in allele and genotype distribution of rs3738952 and haplotype distribution of rs17479770 and rs3738952 between the EH group and normotensive group, whereas the rs17479770 TT genotype in male and the full data set were significantly associated with the decreased risk of EH (P=0.050,P=0.042), and rs17479770 allele T in male was shown to have the correlation tendency of the decreased risk of EH (P=0.064).Conclusion. Our data suggest that theCUL3rs17479770 variant could be a protective factor in the pathogenesis of EH.

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