Lyme Disease and Interdigitation Zone Loss on Optical Coherence Tomography

BackgroundTo develop computer-aided detection (CADe) of ORL abnormalities in the retinal pigmented epithelium, interdigitation zone and ellipsoid zone via optical coherence tomography (OCT).MethodsIn this retrospective study, healthy participants with normal ORL, and patients with abnormality of ORL including choroidal neovascularisation (CNV) or retinitis pigmentosa (RP) were included. First, an automatic segmentation deep learning (DL) algorithm, CADe, was developed for the three outer retinal layers using 120 handcraft masks of ORL. This automatic segmentation algorithm generated 4000 segmentations, which included 2000 images with normal ORL and 2000 (1000 CNV and 1000 RP) images with focal or wide defects in ORL. Second, based on the automatically generated segmentation images, a binary classifier (normal vs abnormal) was developed. Results were evaluated by area under the receiver operating characteristic curve (AUC).ResultsThe DL algorithm achieved an AUC of 0.984 (95% CI 0.976 to 0.993) for individual image evaluation in the internal test set of 797 images. In addition, performance analysis of a publicly available external test set (n=968) had an AUC of 0.957 (95% CI 0.944 to 0.970) and a second clinical external test set (n=1124) had an AUC of 0.978 (95% CI 0.970 to 0.986). Moreover, the CADe highlighted well normal parts of ORL and omitted highlights in abnormal ORLs of CNV and RP.ConclusionThe CADe can use OCT images to segment ORL and differentiate between normal ORL and abnormal ORL. The CADe classifier also performs visualisation and may aid future physician diagnosis and clinical applications.

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Determination of Length of Interdigitation Zone by Optical Coherence Tomography and Retinal Sensitivity by Microperimetry and Their Relationship to Progression of Retinitis Pigmentosa

BioMed Research International ◽

10.1155/2019/1217270 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Akihiro Chiba ◽

Gen Miura ◽

Takayuki Baba ◽

Shuichi Yamamoto

Keyword(s):

Optical Coherence Tomography ◽

Retinitis Pigmentosa ◽

Estimating Equation ◽

University Hospital ◽

Retinal Sensitivity ◽

Optical Coherence ◽

Interdigitation Zone ◽

Baseline Values

Purpose. To investigate the annual progression of retinitis pigmentosa (RP) by changes in retinal sensitivity and length of photoreceptor microstructures. Method. The medical records of patients with typical RP followed at Chiba University Hospital were reviewed. The retinal sensitivity was measured by Micro Perimeter-1, and the lengths of the intact external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ) were measured by spectral-domain optical coherence tomography. The baseline values and annual progression rates were determined. The significance of the correlations among these factors was determined by generalized estimating equation regression analysis. Results. Forty-six eyes of 24 patients who were examined over a mean follow-up period of 3 years were studied. The annual changes in the retinal sensitivity (p = 0.0035) and the lengths of the EZ (p = 0.037) and IZ (p = 0.0033) were significantly correlated with their baseline values. The annual change in the retinal sensitivity was significantly correlated with the length of the EZ at the baseline (p = 0.020). Conclusions. The significant correlation between the annual progression of the retinal sensitivity and the baseline retinal sensitivity and lengths of the EZ and IZ in patients with RP indicate that the retinal sensitivity, the EZ, and the IZ can be useful parameters to predict the annual progression of RP.

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Optical Coherence Tomography Biomarkers of Photoreceptor Degeneration in Retinitis Pigmentosa

10.21203/rs.3.rs-307297/v1 ◽

2021 ◽

Author(s):

Yuting Gong ◽

Honghe Xia ◽

anlin zhang ◽

LiJia Chen ◽

Haoyu Chen

Keyword(s):

Optical Coherence Tomography ◽

Retinitis Pigmentosa ◽

Outer Nuclear Layer ◽

Peripheral Retina ◽

Optical Coherence ◽

Optical Intensity ◽

Horizontal Meridian ◽

Photoreceptor Degeneration ◽

Corrected Visual Acuity ◽

Interdigitation Zone

Abstract Purpose: Several parameters on optical coherence tomography (OCT) have been suggested as biomarkers for photoreceptor degeneration in retinitis pigmentosa (RP). This study is to investigate which OCT parameters can serve as the earliest biomarkers in RP.Methods: OCT line scans of the horizontal meridian were conducted in 22 eyes of 22 RP patients and 30 eyes of 30 healthy controls. Longitudinal reflectance profiles were obtained using ImageJ at every 5 pixels. The following parameters on OCT were quantitatively measured: 1) relative optical intensity (ROI) of ellipsoid zone (EZ) and interdigitation zone (IZ); 2) thickness of outer nuclear layer (ONLT), photoreceptor (PRT), inner segment (IST) and outer segment (OST). The variations of these parameters across different regions were analyzed. Results: From fovea to peripheral retina, all the OCT biomarkers declined before disappeared, except IST and IZ-ROI. There was no identifiable declining zone for the IST and IZ-ROI between the normal and disappeared zones. The earliest biomarker was the shortening of OST and reduced IZ-ROI, followed by the shortening of PRT, EZ-ROI, then IST, and finally, ONLT. All these biomarkers had significant correlations with best-corrected visual acuity, except ONLT.Conclusion: In retinitis pigmentosa, EZ-ROI, IZ-ROI, PRT, OST, IST and ONLT are valuable biomarkers of photoreceptor degeneration. OST and IZ-ROI may serve as the earliest biomarkers.

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Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

European Journal of Ophthalmology ◽

10.1177/1120672119834476 ◽

2019 ◽

Vol 30 (2) ◽

pp. NP16-NP22

Author(s):

María Carmen Guixeres Esteve ◽

Laurence Postelmans

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Spectral Domain ◽

Optical Coherence ◽

Perpendicular Line ◽

Corrected Visual Acuity ◽

Amsler Grid ◽

Interdigitation Zone ◽

Best Corrected Visual Acuity ◽

Grid Test

Purpose: The aim of this study is to report a rare spectral-domain optical coherence tomography finding in the macula. Methods: This is a descriptive consecutive case series. Patients diagnosed with hyperreflective central perpendicular line in the macular spectral-domain optical coherence tomography were included. Best-corrected visual acuity assessment, standard Amsler grid test, biomicroscopic examination and macular spectral-domain optical coherence tomography were performed. Results: We examined three men and one woman, aged 56 to 91 years (average age: 75.25 years). Spectral-domain optical coherence tomography showed a hyperreflective central perpendicular line in five eyes accompanied by vitreofoveal adhesion in all of them. In two eyes, we observed a lifting of the ellipsoid zone, and in one eye the external limiting membrane was also pulled. In one eye, a subtle lifting of the interdigitation zone was revealed. In another eye, we also found a triangular foveolar detachment of the interdigitation zone. Snellen’s best-corrected visual acuity ranged from 0.2 to −0.1 logMAR (average of 0.006 logMAR). Amsler grid test was unremarkable in four eyes and metamorphopsia was detected in one eye. One eye developed a full-thickness macular hole several weeks after the phacoemulsification cataract surgery. Conclusion: The presence of a central perpendicular line can be revealed by the macular spectral-domain optical coherence tomography. We hypothesize that this finding could be considered as a sign of vitreomacular traction. In our patients, best-corrected visual acuity was only mildly reduced, and Amsler grid test was affected in only one eye.

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