Role of Human Herpes Virus 6 in Corneal Inflammation Alone or With Human Herpesviruses

AbstractBackground: There is no consensus in the literature on the role of human herpes virus-6 (HHV-6) in multiple sclerosis (MS) onset or progression.Objective: We evaluated a possible role for HHV-6 in MS onset and progression.Methods: We conducted a literature search of PubMed and Google scholar with the following search terms: (“multiple sclerosis” OR “MS”) and (“Human Herpes Virus-6” OR “HHV-6”).Results: A total 21 publications were retrieved, of which 19 case-control studies were included. A further 25 articles were retrieved for background information.Conclusion: There was insufficient evidence to support a role of HHV-6 in MS onset and progression.

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A Case of Drug-induced Hypersensitivity Syndrome with Reactivated Human Herpes Virus 6 and Transiently Raised IgM Antibody to Parvovirus B19

Nishi Nihon Hifuka ◽

10.2336/nishinihonhifu.71.580 ◽

2009 ◽

Vol 71 (6) ◽

pp. 580-583

Author(s):

Emiko KAMADA ◽

Yohei SANO ◽

Azusa HAYAKAWA ◽

Yasuko YAMADA ◽

Yoshihiro IKEDA ◽

...

Keyword(s):

Herpes Virus ◽

Parvovirus B19 ◽

Hypersensitivity Syndrome ◽

Human Herpes ◽

Drug Induced ◽

Igm Antibody ◽

Human Herpes Virus ◽

Human Herpes Virus 6 ◽

Herpès Virus

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Faculty Opinions recommendation of Epstein-Barr Virus and Human herpes virus 6 Type A DNA Enhance IL-17 Production in Mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725502639.793532097 ◽

2017 ◽

Author(s):

Shabaana Khader ◽

Shibali Das

Keyword(s):

Epstein Barr Virus ◽

Herpes Virus ◽

Type A ◽

Human Herpes ◽

Barr Virus ◽

Human Herpes Virus ◽

Human Herpes Virus 6 ◽

Epstein Barr ◽

Herpès Virus

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Human herpes virus 6 encephalomyelitis after bone marrow transplantation: Report of an autopsy case

Neuropathology ◽

10.1111/j.1440-1789.2009.01020.x ◽

2010 ◽

Vol 30 (1) ◽

pp. 50-55 ◽

Cited By ~ 14

Author(s):

Masayuki Shintaku ◽

Daita Kaneda ◽

Kohei Tada ◽

Harutaka Katano ◽

Tetsutaro Sata

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Marrow Transplantation ◽

Herpes Virus ◽

Autopsy Case ◽

Human Herpes ◽

Human Herpes Virus ◽

Human Herpes Virus 6 ◽

Herpès Virus

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Human herpes virus-6 (HHV-6) pneumonitis and meningitis with viraemia in an immunocompetent adult patient

BMJ Case Reports ◽

10.1136/bcr-2020-239220 ◽

2021 ◽

Vol 14 (3) ◽

pp. e239220

Author(s):

Maria Alkozah ◽

Rami Hallak ◽

Imad Bou Akl ◽

Aline El Zakhem

Keyword(s):

Herpes Virus ◽

Case Reports ◽

Paediatric Population ◽

Atypical Pneumonia ◽

Virus Reactivation ◽

Human Herpes ◽

Serum Samples ◽

Human Herpes Virus ◽

Human Herpes Virus 6 ◽

Herpès Virus

Human herpes virus-6 (HHV-6) infection is a common infection in the paediatric population and is increasingly reported in immunosuppressed adult patients. It has been reported as the causative agent of disease in few case reports in immunocompetent adults. We report herein an unusual case of HHV-6-associated viraemia, pneumonitis and meningitis in a patient who presented with dyspnoea, hypoxia, dry cough and headache. She was treated for atypical pneumonia with no improvement. Meningitis was suspected as headache kept worsening. HHV-6B was detected by PCR in the cerebrospinal fluid, and subsequently, in the bronchoalveolar lavage and serum samples. Studies were negative for the most common primary and secondary immunodeficiency syndromes, and serology could not be performed to differentiate virus reactivation from a primary infection. The patient was successfully treated with ganciclovir and had no residual sequelae.

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