In Vitro Effects of Antivascular Endothelial Growth Factors on Cultured Human Trabecular Meshwork Cells

2010 ◽  
Vol 19 (7) ◽  
pp. 437-441 ◽  
Author(s):  
Malik Y. Kahook ◽  
David A. Ammar
Keyword(s):  
Growth Factors ◽  
Trabecular Meshwork ◽  
Trabecular Meshwork Cells ◽  
In Vitro Effects ◽  
Endothelial Growth Factors

scholarly journals Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma

2020 ◽  
Vol 10 (1) ◽  
pp. 78
Author(s):  
April Nettesheim ◽  
Myoung Sup Shim ◽  
Angela Dixon ◽  
Urmimala Raychaudhuri ◽  
Haiyan Gong ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Cathepsin B ◽  
Molecular Mechanisms ◽  
Culture Media ◽  
Ecm Remodeling ◽  
Trabecular Meshwork Cells ◽  
Proteolytic Cascade

Extracellular matrix (ECM) deposition in the trabecular meshwork (TM) is one of the hallmarks of glaucoma, a group of human diseases and leading cause of permanent blindness. The molecular mechanisms underlying ECM deposition in the glaucomatous TM are not known, but it is presumed to be a consequence of excessive synthesis of ECM components, decreased proteolytic degradation, or both. Targeting ECM deposition might represent a therapeutic approach to restore outflow facility in glaucoma. Previous work conducted in our laboratory identified the lysosomal enzyme cathepsin B (CTSB) to be expressed on the cellular surface and to be secreted into the culture media in trabecular meshwork (TM) cells. Here, we further investigated the role of CTSB on ECM remodeling and outflow physiology in vitro and in CSTBko mice. Our results indicate that CTSB localizes in the caveolae and participates in the pericellular degradation of ECM in TM cells. We also report here a novel role of CTSB in regulating the expression of PAI-1 and TGFβ/Smad signaling in TM cells vitro and in vivo in CTSBko mice. We propose enhancing CTSB activity as a novel therapeutic target to attenuate fibrosis and ECM deposition in the glaucomatous outflow pathway.

scholarly journals Effects of Antiglaucoma Medications on Bovine Trabecular Meshwork Cells In Vitro

1993 ◽  
Vol 57 (5) ◽  
pp. 557-565 ◽  
Author(s):  
Jean E. Kawa ◽  
Eve J. Higginbotham ◽  
Isabel L. Chang ◽  
Beatrice Y.J.T. Yue
Keyword(s):  
Trabecular Meshwork ◽  
Trabecular Meshwork Cells

Effects of dexamethasone on human trabecular meshwork cells in vitro

2013 ◽  
Vol 251 (7) ◽  
pp. 1741-1746 ◽  
Author(s):  
Ashish Sharma ◽  
Alammaprabhu Jayaprakash Patil ◽  
Saffar Mansoor ◽  
Maria F. Estrago-Franco ◽  
Vincent Raymond ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Trabecular Meshwork Cells

scholarly journals 2D- and 3D-cultures of human trabecular meshwork cells: A preliminary assessment of an in vitro model for glaucoma study

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0221942 ◽  
Author(s):  
Stefania Vernazza ◽  
Sara Tirendi ◽  
Sonia Scarfì ◽  
Mario Passalacqua ◽  
Francesco Oddone ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
In Vitro Model ◽  
Preliminary Assessment ◽  
3D Cultures ◽  
Trabecular Meshwork Cells ◽  
Vitro Model ◽  
2D And 3D

In vitro effects of recombinant hemopoietic growth factors on progenitor cells from patients with myelodysplastic syndromes

1991 ◽  
Vol 15 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Xavier Thomas ◽  
Denis Guyotat ◽  
Lydia Campos ◽  
Zhi Hua Shi ◽  
Liliana Vila ◽  
...  
Keyword(s):  
Growth Factors ◽  
Progenitor Cells ◽  
Myelodysplastic Syndromes ◽  
In Vitro Effects

Effect of benzalkonium chloride on trabecular meshwork cells in a new in vitro 3D trabecular meshwork model for glaucoma

2017 ◽  
Vol 41 ◽  
pp. 21-29 ◽  
Author(s):  
Meryem Bouchemi ◽  
Christophe Roubeix ◽  
Karima Kessal ◽  
Luisa Riancho ◽  
Anne-Laure Raveu ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Benzalkonium Chloride ◽  
Trabecular Meshwork Cells
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