Neonatal Herpes Simplex Virus Type-1 Central Nervous System Disease With Acute Retinal Necrosis

2014 ◽  
Vol 33 (4) ◽  
pp. 424-426 ◽  
Author(s):  
Choong Yi Fong ◽  
Aye Mya Min Aye ◽  
Mohammadreza Peyman ◽  
Norazlin Kamal Nor ◽  
Subrayan Visvaraja ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Central Nervous System Disease ◽  
Neonatal Herpes ◽  
System Disease ◽  
Neonatal Herpes Simplex ◽  
Simplex Virus

Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report

2019 ◽  
Vol 51 (03) ◽  
pp. 221-224
Author(s):  
Anthony Grondin ◽  
Eloïse Baudou ◽  
Marlène Pasquet ◽  
Sonia Pelluau ◽  
Karim Jamal-Bey ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex ◽  
Central Nervous System Disease ◽  
Suppressive Therapy ◽  
Neonatal Herpes ◽  
Herpes Simplex Virus 1 ◽  
System Disease ◽  
Neonatal Herpes Simplex ◽  
Simplex Virus

AbstractSeventeen-day-old twins were hospitalized for neonatal herpes simplex virus 1 (HSV-1) with central nervous system disease and internal capsule and thalamic lesions on magnetic resonance imaging (MRI). They were treated with the usual intravenous (IV) treatment and oral therapy for 6 months. The clinical course was good in both children with negative HSV polymerase chain reaction on completion of IV therapy. The neurological condition recurred in one child with new radiological lesions at 7 months of age, 2 weeks after discontinuation of oral treatment. Cerebral lesions highlighted on the MRI scan are specific to the neonatal period and impact long-term prognosis. The likely genetic predisposition in this case is interesting and requires further investigation. In addition, this case raises questions about the duration of oral acyclovir suppressive therapy.

scholarly journals LATENT HERPES SIMPLEX VIRUS IN THE CENTRAL NERVOUS SYSTEM OF RABBITS AND MICE

1973 ◽  
Vol 138 (3) ◽  
pp. 740-744 ◽  
Author(s):  
F. B. Knotts ◽  
M. L. Cook ◽  
J. G. Stevens
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Organ Cultures ◽  
The Central Nervous System ◽  
Simplex Virus ◽  
The Brain

Herpes simplex virus (HSV) type 1 induces a long-standing latent infection in the central nervous system of mice and rabbits. The infection was extablished in the brain stems of rabbits after corneal inoculation of the virus, and in the spinal cords of mice after rear footpad infection. In these animals, infectious virus could not be recovered by direct isolation from tissues; it was detected only after the tissues were maintained as organ cultures in vitro.

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