Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report

2019 ◽  
Vol 51 (03) ◽  
pp. 221-224
Author(s):  
Anthony Grondin ◽  
Eloïse Baudou ◽  
Marlène Pasquet ◽  
Sonia Pelluau ◽  
Karim Jamal-Bey ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex ◽  
Central Nervous System Disease ◽  
Suppressive Therapy ◽  
Neonatal Herpes ◽  
Herpes Simplex Virus 1 ◽  
System Disease ◽  
Neonatal Herpes Simplex ◽  
Simplex Virus

AbstractSeventeen-day-old twins were hospitalized for neonatal herpes simplex virus 1 (HSV-1) with central nervous system disease and internal capsule and thalamic lesions on magnetic resonance imaging (MRI). They were treated with the usual intravenous (IV) treatment and oral therapy for 6 months. The clinical course was good in both children with negative HSV polymerase chain reaction on completion of IV therapy. The neurological condition recurred in one child with new radiological lesions at 7 months of age, 2 weeks after discontinuation of oral treatment. Cerebral lesions highlighted on the MRI scan are specific to the neonatal period and impact long-term prognosis. The likely genetic predisposition in this case is interesting and requires further investigation. In addition, this case raises questions about the duration of oral acyclovir suppressive therapy.

Neonatal Herpes Simplex Virus Type-1 Central Nervous System Disease With Acute Retinal Necrosis

2014 ◽  
Vol 33 (4) ◽  
pp. 424-426 ◽  
Author(s):  
Choong Yi Fong ◽  
Aye Mya Min Aye ◽  
Mohammadreza Peyman ◽  
Norazlin Kamal Nor ◽  
Subrayan Visvaraja ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Central Nervous System Disease ◽  
Neonatal Herpes ◽  
System Disease ◽  
Neonatal Herpes Simplex ◽  
Simplex Virus

scholarly journals Varicella-Zoster Virus (VZV) Glycoprotein E Is a Serological Antigen for Detection of Intrathecal Antibodies to VZV in Central Nervous System Infections, without Cross-Reaction to Herpes Simplex Virus 1

2011 ◽  
Vol 18 (8) ◽  
pp. 1336-1342 ◽  
Author(s):  
Anna Grahn ◽  
Marie Studahl ◽  
Staffan Nilsson ◽  
Elisabeth Thomsson ◽  
Malin Bäckström ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Igg Antibodies ◽  
Herpes Simplex Virus 1 ◽  
Glycoprotein E ◽  
Varicella Zoster ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACTHerpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) cause serious central nervous system (CNS) diseases that are diagnosed with PCR using samples of cerebrospinal fluid (CSF) and, during later stages of such infections, with assays of intrathecal IgG antibody production. However, serological diagnoses have been hampered by cross-reactions between HSV-1 and VZV IgG antibodies and are commonly reported in patients with herpes simplex encephalitis (HSE). In this study we have evaluated VZV glycoprotein E (gE) as a new antigen for serological diagnosis of VZV-induced CNS infections. Paired samples of CSF and serum from 29 patients with clinical diagnosis of VZV CNS infection (n= 15) or HSE (n= 14), all confirmed by PCR, were analyzed. VZV gE and whole VZV were compared as antigens in enzyme-linked immunosorbent assays (ELISAs) for serological assays in which the CSF/serum sample pairs were diluted to identical IgG concentrations. With the gE antigen, none of the HSE patients showed intrathecal IgG antibodies against VZV, compared to those shown by 11/14 patients using whole-VZV antigen (P< 0.001). In the patients with VZV infections, significantly higher CSF/serum optical density (OD) ratios were found in the VZV patients using the VZV gE antigen compared to those found using the whole-VZV antigen (P= 0.001). These results show that gE is a sensitive antigen for serological diagnosis of VZV infections in the CNS and that this antigen was devoid of cross-reactivity to HSV-1 IgG in patients with HSE. We therefore propose that VZV gE can be used for serological discrimination of CNS infections caused by VZV and HSV-1.

Case 40

2020 ◽  
pp. 277-280
Author(s):  
Seilesh Kadambari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Viral Infection ◽  
Central Nervous System Disease ◽  
Multiple Organ ◽  
Nervous System Disease ◽  
Significant Morbidity ◽  
Neonatal Herpes ◽  
Disseminated Infection ◽  
System Disease

Neonatal herpes is a rare but serious viral infection and can cause significant morbidity and mortality. Neonatal herpes is classified as either disease localized to skin, eye, and mouth (SEM), central nervous system disease (CNS), or disseminated infection with multiple organ involvement. More than 80% of neonates with SEM have skin vesicles. Disseminated infection should be considered in neonates with sepsis-like syndrome, severe hepatic dysfunction, or coagulation abnormalities. Infants with disseminated and SEM disease typically present within the first 2 weeks of life and infants with CNS disease within the second and third week of life.

scholarly journals Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Michael Glas ◽  
Sigrun Smola ◽  
Thorsten Pfuhl ◽  
Juliane Pokorny ◽  
Rainer M. Bohle ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Multiorgan Failure ◽  
Acute Infection ◽  
B Cell Lymphoma ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus type 1 (HSV-1) infections cause typical dermal and mucosal lesions in children and adults. Also complications to the peripheral and central nervous system, pneumonia or hepatitis are well known. However, dissemination to viscera in adults is rare and predominantly observed in immunocompromised patients. Here we describe the case of a 70-year-old male admitted with macrohematuria and signs of acute infection and finally deceasing in a septic shock with multi organ failure 17 days after admission to intensive care unit. No bacterial or fungal infection could be detected during his stay, but only two days before death the patient showed signs of rectal, orolabial and genital herpes infection. The presence of HSV-1 was detected in swabs taken from the lesions, oropharyngeal fluid as well as in plasma. Post-mortem polymerase chain reaction analyses confirmed a disseminated infection with HSV-1 involving various organs and tissues but excluding the central nervous system. Autopsy revealed a predominantly retroperitoneal diffuse large B-cell lymphoma as the suspected origin of immunosuppression underlying herpes simplex dissemination.

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