scholarly journals Prevalence of Latent Tuberculosis Infection Among Healthy Young Children and Adolescents and a Two-step Approach for the Diagnosis of Tuberculosis Infection in Chengdu, China

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jihang Jia ◽  
Dapeng Chen ◽  
Li Liu ◽  
Mohd Jaish Siddiqui ◽  
Fan Yang ◽  
...  
2020 ◽  
Vol 92 ◽  
pp. S26-S30 ◽  
Author(s):  
Valentina Alexandrovna Aksenova ◽  
Irina Anatolievna Vasilyeva ◽  
Tereza Chermenovna Kasaeva ◽  
Anastasia Gennadievna Samoilova ◽  
Natalia Yurievna Pshenichnaya ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0164181 ◽  
Author(s):  
Tomas Maria Perez-Porcuna ◽  
Hélio Doyle Pereira-da-Silva ◽  
Carlos Ascaso ◽  
Adriana Malheiro ◽  
Samira Bührer ◽  
...  

2020 ◽  
Vol 97 (12) ◽  
pp. 28-32
Author(s):  
A. A. Elov ◽  
M. A. Vladimirskiy ◽  
S. V. Smerdin ◽  
O. I. Elufimova

The objective: to analyze the expression of certain genes in the blood cells of children and adolescence to differentiate the active and latent phases of tuberculosis infection.Subjects and methods. Peripheral blood samples collected in 36 pediatric patients with latent tuberculosis infection and 24 patients aged 1 to 16 years undergoing in-patient treatment for pulmonary tuberculosis were tested. A modified method for isolating messenger RNA and reverse transcriptional polymerase chain reaction was used to identify the transcription of six genes selected for analysis.Results. In a comparative study of the expression values of six promising genes in blood cells in the study of two groups of children and adolescents with latent and active tuberculosis infection, it was found that the most differentiating feature for determining active tuberculosis infection was a significantly higher level of expression of PDCD1 gene encoding PD1 lymphocyte receptor. At the same time, the sensitivity to detect the active infection was found to be 95.8%, specificity – 94.4%, the accuracy of the positive prognosis of active tuberculosis infection was 93.3%.


PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0154843 ◽  
Author(s):  
Angela Marcia Cabral Mendonça ◽  
Afrânio Lineu Kritski ◽  
Marcelo Gerardin Poirot Land ◽  
Clemax Couto Sant’Anna

Tuberculosis ◽  
2020 ◽  
Vol 120 ◽  
pp. 101893 ◽  
Author(s):  
Christiane M. Schmidt ◽  
Kathryn L. Lovero ◽  
Fabiana R. Carvalho ◽  
Daniele C.M. dos Santos ◽  
Ana Cláudia M.W. Barros ◽  
...  

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