scholarly journals Korelasi Total Lymphocyte Count terhadap CD4 pada anak dengan Infeksi Human Immunodeficiency Virus

Sari Pediatri ◽  
2016 ◽  
Vol 15 (2) ◽  
pp. 81
Author(s):  
Aulia Fitri Swity ◽  
Djatnika Setiabudi ◽  
Herry Garna
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte ◽  
Immunodeficiency Virus ◽  
Hiv Aids

Latar belakang.Epidemi infeksi human immunodeficiency virus (HIV) merupakan tantangan besar dalam permasalahan kesehatan di dunia. Di Indonesia, jumlah kasus HIV/AIDS anak semakin meningkat tiap tahunnya. Pemantauan jumlah CD4 dapat membantu memutuskan dimulainya pemberian terapi anti- CD4 dapat membantu memutuskan dimulainya pemberian terapi antiretroviral/ARV, tetapi pemeriksaannya mahal dan tidak selalu tersedia di sarana kesehatan. Total lymphocyte count (TLC) diajukan sebagai panduan alternatif selain jumlah CD4 pada keadaan sarana kesehatan yang terbatas. Tujuan. Menentukan korelasi TLC dengan jumlah CD4, dan menentukan jumlah CD4 berdasarkan pemeriksaan TLC pada anak HIV.Metode. Penelitian potong lintang berupa observasional analitik, pengambilan data secara retrospektif rekam medis anak HIV yang dirawat inap di Departemen/SMF Ilmu Kesehatan Anak dan rawat jalan di Klinik Teratai Rumah Sakit Dr. Hasan Sadikin, Bandung. Dilakukan analisis regresi linier pada faktor-faktor yang berhubungan bermakna dengan CD4 untuk menentukan korelasi TLC dengan CD4, serta nilai hitung CD4 dari TLC. Kemaknaan ditentukan berdasarkan nilai p<0,05. Hasil.Subjek penelitian 67 anak HIV, terdiri dari 35 (52%) laki-laki dan 32 (48%) perempuan. Rentang jumlah CD4 berkisar antara 6–3.094 mm3, rerata 444,3 mm3(SD 536,3), median 241 mm3,dan rentang jumlah TLC antara 525–10.738, rerata 3.352,4 (SD 2.020,4), median 2.898. Analisis regresi menunjukkan hubungan linier antara jumlah CD4 sebagai variabel tergantung (Y) dan TLC sebagai variabel bebas (X) menggunakan persamaan Y= -158,209+0,180X. Didapatkan korelasi kuat antara TLC dan jumlah CD4 (r=0,68; p<0,001). Kesimpulan.Terdapat hubungan positif antara jumlah limfosit dan jumlah CD4. Jumlah CD4 pada pasien HIV anak dapat diperkirakan dari jumlah limfosit. Diperlukan penelitian lebih lanjut untuk menentukan cut off point TLC dalam inisiasi ARV

scholarly journals Human immunodeficiency virus in institutionalized elderly people

2016 ◽  
Vol 134 (6) ◽  
pp. 528-533
Author(s):  
Milton Luiz Gorzoni ◽  
Sueli Luciano Pires ◽  
Lilian de Fátima Costa Faria ◽  
Márcia Regina Valadares Aguado ◽  
Miriam Carmen Santana
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B ◽  
Lymphocyte Count ◽  
Antiretroviral Drugs ◽  
Total Lymphocyte Count ◽  
Hiv Positive ◽  
Hiv Diagnosis ◽  
Total Lymphocyte ◽  
Hospital Infection Control ◽  
Immunodeficiency Virus

ABSTRACT CONTEXT AND OBJECTIVE: A search in the SciELO and PubMed databases showed few studies on human immunodeficiency virus (HIV) positive individuals in long-term care institutions (LTCIs), thus prompting the present study. The aim of this study was to ascertain whether there were any HIV-positive individuals in LTCIs for the elderly. DESIGN AND SETTING: Cross-sectional study in which the Hospital Infection Control Committee (HICC) of a 405-bed LTCI was consulted. METHODS: The medical records of 405 individuals interned in the LTCI who had been tested for HIV infection were requested for analysis of the following variables: [1] age and gender; [2] length of stay at LTCI (months); [3] causes and diagnoses on admission to LTCI according to International Classification of Diseases, 10th edition; [4] date of HIV diagnosis; [5] seropositivity for syphilis and hepatitis B and C viruses; [6] medications used at last prescription in medical file; and [7] mean CD4 lymphocyte count based on: total lymphocyte count/6 and total lymphocyte count x 0.8 x 0.2 or 0.3. RESULTS: Four men were HIV-positive, with mean age 71.2 ± 8.6 years, LTCI stay 74.2 ± 38.1 months and length of HIV diagnosis 24.5 ± 17 months (confirmed by HICC standard screening). Three had stroke sequelae; one, dementia syndrome; two, seropositivity for syphilis; two, hepatitis B and one, hepatitis C. The main drugs used were lamivudine, zidovudine, lopinavir, ritonavir, levothyroxine, omeprazole, ranitidine, lactulose and risperidone. The estimated CD4 count was 341 ± 237/mm3. CONCLUSIONS: HIV-positive individuals are present in LTCIs, diagnosable through serological screening and treatable with antiretroviral drugs.

scholarly journals Total Lymfosit Count (TLC) with CD4 in HIV/AIDS Patients at Kupang

2019 ◽  
Vol 8 (2) ◽  
pp. 70-75
Author(s):  
Adrianus Ola Wuan ◽  
Ayorince Herlinalt Gloria Banunu ◽  
Norma Tiku Kambuno
Keyword(s):  
Lymphocyte Count ◽  
Strong Relationship ◽  
Total Lymphocyte Count ◽  
Spearman Correlation ◽  
Aids Patients ◽  
Cross Sectional ◽  
Total Lymphocyte ◽  
Cross Sectional Design ◽  
Limited Health ◽  
Hiv Aids

Human Immunodeficiency Virus (HIV) is a retrovirus originating from the retroviridae family of the genus lentivirus that infects and damages cells that have a molecule Cluster of Differentiation 4 (CD4), especially T lymphocytes that have receptors with high affinity for HIV. Total lymphocyte count / TLC has been proposed as an alternative guide to CD4 in limited health facilities. This study aims to determine the correlation between Total Lymphocyte Count (TLC) and CD4 in HIV/AIDS patients in the W.Z. Johannes Kupang hospital. The type of this research was observational analytic with a cross-sectional design. The study was conducted on 121 samples of patients who performed CD4 examination and Total Lymphocytic Count (TLC) in the laboratory of W.Z.Johannes Kupang Hospital. The Spearman correlation test shows a significance value of 0,000 with a Spearman correlation value of 0.799. Based on the results of this study it can be concluded that there is a significant correlation between Total Lymphocyte Count and CD4 and shows the direction of positive correlation with a very strong relationship, where the increase in the number of Total Lymphocyte Count is in line with the increase in CD4 counts.

scholarly journals Perbandingan Kadar CD4 dan Total Lymphocyte Count dengan Kombinasi Highly Active Antiretroviral Therapy pada pasien HIV/AIDS di RSUP Dr.Kariadi Semarang

2020 ◽  
Vol 9 (1) ◽  
pp. 59
Author(s):  
Iraisa Rosaria
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Highly Active ◽  
Total Lymphocyte ◽  
Hiv Aids

Tujuan: Membuktikan perbedaan jenis pemberian kombinasi Highly Active Antiretroviral Therapy dengan perubahan kadar CD4 dan Total Lymphocyte Count pada pasien HIV/AIDS di RSUP Dr. Kariadi Semarang. Metode: Penelitian ini bersifat analitik yang dilakukan dengan rancangan studi potong lintang. Sampel diambil secara total sampling, yaitu seluruh pasien HIV/ AIDS yang berobat di RSUP Dr. Kariadi Semarang selama 2018 sampai 2019 yang memenuhi kriteria inklusi dan mendapat pengobatan salah satu dari kombinasi Highly Active Antiretroviral Therapy (HAART). Keenam jenis kombinasi HAART tersebut adalah kombinasi I (Efavirens+ Lamivudin+ Tenofovir), II (Evafirenz+ Lamivudin+Zidovudin), III(Nevirapine+ Lamivudin+ Tenofovir), IV (Lamivudine+Zidovudine+Nevirapine), V (Lamivudine+Tenofovir+Rilvipirine), VI (Tenofovir+ Rilvipirine+ Emtricitabine). Data dikumpulkan dari rekam medis pasien dan dianalisis dengan uji Kruskal-Wallis. Hasil:  Dari  89 pasien, didapatkan keenam kombinasi HAART tersebut memberikan efikasi yang baik berdasarkan kenaikan jumlah CD4 dan TLC rerata. Ada perbedaan kenaikan CD4 rerata yang bermakna pada pasien HIV/AIDS antara yang mendapat obat HAART kombinasi I (p  = 0,038), II (p = 0,034), IV (p  = 0,001), V (p  = 0,040), VI (p  = 0,006). Pada Total Lymphocyte Count  (TLC) didapatkan perbedaan kenaikan rerata (p< 0,05) pada  semua  kombinasi HAART. Simpulan: Tidak ada perbedaan jenis pemberian kombinasi Highly Active Antiretroviral Therapy dengan perubahan kadar CD4 dan Total Lymphocyte Count (p> 0,05) pada pasien HIV / AIDS di RSUP Dr. Kariadi Semarang.Kata kunci: CD4, highly active antiretroviral therapy, ODHA, total lymphocyte count

scholarly journals PREDIKSI JUMLAH SEL LIMFOSIT T CD4+ MENGGUNAKAN NILAI TLC (TOTAL LYMPHOCYTE COUNT) PADA PENDERITA HIV/AIDS

2018 ◽  
Vol 14 (2) ◽  
pp. 64
Author(s):  
Rostina Rostina ◽  
Suci Aprianti ◽  
Mansyur Arif
Keyword(s):  
Lymphocyte Count ◽  
Pearson Correlation ◽  
Total Lymphocyte Count ◽  
Cd4 Count ◽  
Fisher Exact Test ◽  
Aids Patients ◽  
Cut Point ◽  
Total Lymphocyte ◽  
Sensitivity Specificity ◽  
Hiv Aids

AIDS is a severe disease caused by Human Immunodeficiency Virus (HIV) that affects patient’s immune system, especially CD4+ Tcells (CD4). Hence, CD4 count is used as parameter to starting ARV treatment or monitoring the progress of the disease. However, themeasurement of CD4 is expensive and available in big hospitals. In small or remote hospitals there are no means to measure the CD4.Some studies suggest that in an area where CD4 count is unavailable, the total lymphocyte count (TLC) of HIV/AIDS patients can roughlybe used to predict CD4 values. This study is aimed to see whether the TLC values can be used to roughly predict the CD4 count of HIV/AIDS patients and to formulate the correlation form between them. A cross sectional study design was applied to 79 blood samples ofHIV/AIDS patients from Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital from January to September 2007. The bloodsamples were tested for TLC as well as CD4 values. The correlation of TLC and CD4 values was tested with Pearson Correlation Test andthe correlation formula was derived from curve estimation of Regression Analysis. Sensitivity, specificity, PPV and NPV of various cutpoint of TLC (1000, 1200, 1500, 2000) to predict CD4 < 200/ul were determined using cross tabulation Fisher Exact Test. A positivecorrelation was found between TLC and CD4 count (R = 0.528, p < 0.001) with the regression formula is CD4 = 0.09TLC – 1.42.The WHO standard cut point TLC1200/ul give best result for sensitivity, specificity, PPV and NPV: 80.6%, 91.7%, 98.2% and 45.8%,respectively. The cut point of TLC1200 can be used to roughly predict CD4 < 200/ul of HIV/AIDS patients, so, can be use as a mark forstarting ARV therapy in the place were measurement of CD4 is unavailable

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