Vitamin D Deficiency Associated With Increased Incidence of Gastrointestinal and Ear Infections in School-age Children

Objective. To evaluate vitamin D status and deficiency in Mexican children and related factors, with updated data from a representative national survey. Materials and methods. Data and serum samples of child participants were collected in the Ensanut 2018-19. The measurement 25-(OH)-D was obtained through chemiluminescence. Height and weight, as well as dietary information, were measured using a semi-quantitative food frequency questionnaire and sociodemographic information. Results. Data of 4 691 children aged 1-11 years were analyzed. Vitamin D deficiency (25-OH-D<50 nmol/L) was found in 27.3% of pre-school-age children and 17.2% of school-age children, and was positively associated with the body mass index (BMI). Main dietary sources were milk, eggs and dairy products, which in combination provided >70% of vitamin D intake. Conclusions. Vitamin D deficiency is important in Mexican children. Actions and programs to fight this deficiency are required.

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P146 Estimation of vitamin D deficiency in healthy school-age children: current status in Italy

Digestive and Liver Disease ◽

10.1016/s1590-8658(18)31144-7 ◽

2018 ◽

Vol 50 (4) ◽

pp. e409

Author(s):

T. Galeazzi ◽

C. Monachesi ◽

A.K. Verma ◽

M. Brugia ◽

L. Marinelli ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Current Status ◽

School Age Children ◽

School Age

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Vitamin D deficiency is common and is associated with overweight in Mexican children aged 1–11 years

Public Health Nutrition ◽

10.1017/s1368980017000040 ◽

2017 ◽

Vol 20 (10) ◽

pp. 1807-1815 ◽

Cited By ~ 11

Author(s):

Amada Flores ◽

Mario Flores ◽

Nayeli Macias ◽

Lucía Hernández-Barrera ◽

Marta Rivera ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

School Children ◽

School Age Children ◽

School Age ◽

Nutrition Survey ◽

Hydroxyvitamin D ◽

Vitamin D Intake ◽

Mexican Children ◽

25 Hydroxyvitamin D

AbstractObjectiveTo assess vitamin D dietary sources, intake and 25-hydroxyvitamin D status and their association with individual and sociodemographic characteristics in Mexican children.DesignData obtained from 2695 children aged 1–11 years from the Mexican National Health and Nutrition Survey (2012) were analysed. Diet was assessed by a 141-item FFQ. 25-Hydroxyvitamin D was measured by a chemiluminescent assay.ResultsMean vitamin D intake was 3·38 (se 0·09) µg/d (135·2 (se 3·6) IU/d) among pre-school children and 2·85 (se 0·06) µg/d (114·0 (se 2·4) IU/d) in school-age children. Milk accounted for 64·4 % of vitamin D intake in pre-school children and 54·7 % in school-age children. Vitamin D deficiency (serum 25-hydroxyvitamin D<50 nmol/l) was 25·9 % in pre-schoolers and 36·6 % in school-age children. Overweight/obese school-age children had a higher risk of vitamin D deficiency compared with normal-weight children (OR=2·23; 95 % CI 1·36, 3·66; P<0·05).ConclusionsVitamin D intakes are low in Mexican children, and milk is the main source of the vitamin. Vitamin D deficiency is common and associated with overweight in school-age children.

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Vitamin D Deficiency and Indicators of Increased Adiposity in School-age Children: A Prospective Study

Epidemiology ◽

10.1097/01.ede.0000392581.80941.ac ◽

2011 ◽

Vol 22 ◽

pp. S287

Author(s):

Diane Gilbert-Diamond ◽

Ana Baylin ◽

Mercedes Mora-Plazas ◽

Constanza Marin ◽

Michael Hughes ◽

...

Keyword(s):

Vitamin D ◽

Prospective Study ◽

Vitamin D Deficiency ◽

School Age Children ◽

School Age ◽

A Prospective Study

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Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children

Epidemiology and Infection ◽

10.1017/s0950268818002066 ◽

2018 ◽

Vol 146 (15) ◽

pp. 1996-2002

Author(s):

K.M. Palframan ◽

S.L. Robinson ◽

M. Mora-Plazas ◽

C. Marin ◽

E. Villamor

Keyword(s):

Vitamin D ◽

Binding Protein ◽

Incidence Rates ◽

School Age Children ◽

School Age ◽

Vitamin D Binding Protein ◽

Infectious Morbidity ◽

School Year ◽

Ear Infections ◽

Rate Ratios

AbstractCirculating 25-hydroxy vitamin D (25(OH)D) is related to decreased rates of gastrointestinal and ear infections in school-age children. Vitamin D-binding protein (DBP) transports 25(OH)D and exerts immunological functions; however, it is unknown whether DBP is associated with infectious morbidity in children. We quantified plasma DBP concentrations in 540 school-age children at the time of recruitment into a cohort study in Bogotá, Colombia and obtained daily information on infectious morbidity symptoms and doctor visits during the school year. We compared the incidence rates of gastrointestinal and respiratory symptoms across quartiles of DBP concentration by estimating adjusted incidence rate ratios (IRRs) with 95% confidence interval (CI). We also estimated the per cent of the associations between DBP and morbidity that were mediated through 25(OH)D using a counterfactual frame. Mean ±s.d.DBP concentration was 2650 ± 1145 nmol/l. DBP was inversely associated with the rates of diarrhoea with vomiting (IRR for quartiles 2–4vs.1 = 0.48; 95% CI 0.25–0.92;P= 0.03) and earache/ear discharge with fever (IRR for quartiles 2–4vs.1 = 0.29; 95% CI 0.12–0.71;P= 0.006). The DBP–morbidity associations were not mediated through 25(OH)D. We conclude that plasma DBP predicts lower incidence of gastrointestinal and ear infections in school-age children independent of 25(OH)D.

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Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study

American Journal of Clinical Nutrition ◽

10.3945/ajcn.2010.29746 ◽

2010 ◽

Vol 92 (6) ◽

pp. 1446-1451 ◽

Cited By ~ 90

Author(s):

Diane Gilbert-Diamond ◽

Ana Baylin ◽

Mercedes Mora-Plazas ◽

Constanza Marin ◽

Joanne E Arsenault ◽

...

Keyword(s):

Vitamin D ◽

Prospective Study ◽

Vitamin D Deficiency ◽

School Age Children ◽

School Age ◽

Anthropometric Indicators ◽

A Prospective Study

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Faculty Opinions recommendation of Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717953480.793460565 ◽

2012 ◽

Author(s):

Susan Coffin

Keyword(s):

Vitamin D ◽

Tuberculin Skin Test ◽

Skin Test ◽

Latent Tuberculosis ◽

Feasibility Trial ◽

School Age Children ◽

School Age ◽

Double Blind ◽

Double Blind Placebo ◽

Tuberculin Skin Test Conversion

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Vitamin D for secondary prevention of acute wheeze attacks in preschool and school-age children

Thorax ◽

10.1136/thoraxjnl-2019-213278 ◽

2019 ◽

Vol 74 (10) ◽

pp. 977-985 ◽

Cited By ~ 3

Author(s):

Christos Stefanidis ◽

Adrian R Martineau ◽

Chinedu Nwokoro ◽

Christopher J Griffiths ◽

Andrew Bush

Keyword(s):

Vitamin D ◽

Secondary Prevention ◽

Vitamin D Supplementation ◽

Small Sample ◽

Preschool Age ◽

School Age Children ◽

School Age ◽

Vitamin D Status ◽

Increased Risk ◽

Tract Infections

IntroductionVitamin D is best known for its role in bone health; however, the discovery of the vitamin D receptor and the expression of the gene encoding the vitamin D 1α-hydroxylase (CYP27B1) enzyme in a wide variety of tissues including immune cells and respiratory epithelium has led to the discovery of potential roles for vitamin D in the prevention of acute wheeze.MethodsWe review here the literature concerning the relationships between circulating 25-hydroxyvitamin D (25(OH)D) concentration and secondary prevention of acute wheeze attacks in preschool and school-age children.ResultsEpidemiological data suggest that vitamin D insufficiency (25(OH)D <75 nmol/L) is highly prevalent in preschool and school-age children with wheeze. Preschool age children with a history of wheeze attacks and circulating 25(OH)D <75 nmol/L are at increased risk and frequency of future acute wheeze. However, no consistent association between low vitamin D status and risk of acute wheeze is reported in school-age children. Seven randomised controlled trials (RCTs) with relatively small sample sizes (30–430) and variable quality showed inconsistent results regarding the effect of oral vitamin D supplementation during childhood on the risk of asthma attacks, asthma symptom control, inhaled corticosteroid requirements, spirometry and unscheduled healthcare attendances for wheeze. A RCT showed that vitamin D supplementation had no effect on the frequency of unplanned healthcare attendances due to acute wheeze in 22 preschool children.DiscussionAn evidence-based recommendation for the use of vitamin D as a preventive therapy for wheeze attacks cannot be made until results of further trials are available. The assessment of circulating 25(OH)D concentration and the optimisation of vitamin D status to prevent acute respiratory tract infections, and to maintain skeletal and general health in preschool and school-age children with acute wheeze is worthwhile in its own right, but whether this will reduce the risk of acute wheeze attacks is unclear.

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Calcium absorption and vitamin D status in school age children

The FASEB Journal ◽

10.1096/fasebj.23.1_supplement.112.4 ◽

2009 ◽

Vol 23 (S1) ◽

Author(s):

Steven A Abrams ◽

Penni D Hicks ◽

Keli M Hawthorne

Keyword(s):

Vitamin D ◽

Calcium Absorption ◽

School Age Children ◽

School Age ◽

Vitamin D Status

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