Successful Treatment of Extensive Squamous Cell Carcinoma of the Conjunctiva and Upper Eyelid Skin With Topical Therapy Alone

2017 ◽  
Vol 33 ◽  
pp. S4-S6
Author(s):  
Grace Huang ◽  
Neena Mirani ◽  
Adrian Connally ◽  
Paul D. Langer
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Successful Treatment ◽  
Topical Therapy ◽  
Upper Eyelid ◽  
Eyelid Skin

Successful treatment of oral squamous cell carcinoma with intra-arterial cisplatin and concurrent radiotherapy

2014 ◽  
Vol 41 (2) ◽  
pp. 172-173
Author(s):  
Shinichi Koba ◽  
Noriyuki Misago ◽  
Reiko Shirai ◽  
Sunao Tokumaru ◽  
Tomoyuki Noguchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Successful Treatment ◽  
Concurrent Radiotherapy

scholarly journals Concurrent squamous cell carcinoma and hemangiosarcoma in the cornea of a cat

2016 ◽  
Vol 85 (1) ◽  
pp. 31-35
Author(s):  
G. Storms ◽  
C. Naranjo ◽  
M. Grauwels
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Corneal Stroma ◽  
Lower Eyelid ◽  
Upper Eyelid ◽  
Multiple Primary Neoplasms ◽  
Corneal Epithelial ◽  
Primary Neoplasms ◽  
Corneal Biopsy

A 14-year-old, female, spayed Domestic Shorthair cat was presented for evaluation of a dark red mass occupying about 75% of the cornea of the left eye. Furthermore, the eye presented upper eyelid trichiasis, lower eyelid entropion and a marked symblepharon. The fellow eye presented upper eyelid trichiasis, lower eyelid entropion, extensive symblepharon and chronic stromal ulcerative keratitis. Based on the results of a corneal biopsy of the left eye, a corneal squamous cell carcinoma was diagnosed and an enucleation was performed subsequently. Histopathology of the globe revealed the presence of variably sized, vascular-like, blood-filled channels in the superficial corneal stroma, lined by spindle cells. In the central cornea, a markedly hyperplastic epithelium was noticed with infiltration of atypical corneal epithelial cells into the superficial stroma. A primary corneal hemangiosarcoma associated with a primary corneal squamous cell carcinoma was diagnosed. In this case report, the rare presence of multiple primary neoplasms within the same anatomical structure is described.

scholarly journals Evaluation of Telomerase Reverse Transcriptase Expression in Squamous Cell Carcinoma of the Skin

2021 ◽  
Author(s):  
Nimita Kant ◽  
Perumal Senthiappan Jayaraj
Keyword(s):  
Squamous Cell Carcinoma ◽  
Reverse Transcriptase ◽  
Cell Carcinoma ◽  
Expression Pattern ◽  
Squamous Cell ◽  
Dna Sequences ◽  
Core Promoter ◽  
Telomerase Reverse Transcriptase ◽  
Eyelid Skin ◽  
Mutational Status

Abstract Introduction Squamous cell carcinoma (SCC) is highly invasive malignant tumor showing keratinocytic differentiation and is often associated with chronic exposure to UV light. Telomerase is RNA dependent DNA polymerase that causes addition of telomeric repeat DNA sequences to chromosomal ends. Recently, UV signature mutations have been identified in core promoter region of TERT gene, which encodes the main catalytic subunit leading to overexpression in cutaneous melanoma. However, its role and expression pattern have not been studied in eyelid skin SCC. Objectives Present study aimed to analyze the presence of telomerase reverse transcriptase (TERT) in eyelid SCC, as its expression pattern and mutational status have not been studied in SCC. Materials and Methods Nineteen cases of eyelid SCC were evaluated for the presence of TERT protein using monoclonal antibody against TERT, and its mutational status was verified using PCR and DNA sequencing. Bioedit software was used for analyzes and primers were vindicated using NCBI Primer Blast. Results were correlated with clinicopathological features of SCC. Results A C to T mutation was observed in 6 of 19 SCC cases. Positive expression of TERT was found in 57% of the cases analyzed and it showed a significant association with keratinocytic differentiation (p = 0.04). Conclusion Relation between TERT promoter mutation and TERT immunohistochemistry is studied for the first time in eyelid skin SCC. Our results suggested that overexpression of TERT may contribute to the aggressive behavior associated with SCC and such patients may warrant aggressive treatment.

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