scholarly journals A systematic review and meta-analysis of cannabis-based medicines, cannabinoids and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nadia Soliman ◽  
Simon Haroutounian ◽  
Andrea G. Hohmann ◽  
Elliot Krane ◽  
Jing Liao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Meta Analysis ◽  
Endocannabinoid System ◽  
Persistent Pain ◽  
Antinociceptive Effects ◽  
Models Of Injury

scholarly journals A protocol for the systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain

2021 ◽  
Vol 5 (1) ◽  
pp. e100135
Author(s):  
Xue Ying Zhang ◽  
Jan Vollert ◽  
Emily S Sena ◽  
Andrew SC Rice ◽  
Nadia Soliman
Keyword(s):  
Systematic Review ◽  
Outcome Measure ◽  
Meta Analysis ◽  
Persistent Pain ◽  
Effect Sizes ◽  
Bias Assessment ◽  
Animal Pain ◽  
Trim And Fill ◽  
Meta Analyses ◽  
The Impact

ObjectiveThigmotaxis is an innate predator avoidance behaviour of rodents and is enhanced when animals are under stress. It is characterised by the preference of a rodent to seek shelter, rather than expose itself to the aversive open area. The behaviour has been proposed to be a measurable construct that can address the impact of pain on rodent behaviour. This systematic review will assess whether thigmotaxis can be influenced by experimental persistent pain and attenuated by pharmacological interventions in rodents.Search strategyWe will conduct search on three electronic databases to identify studies in which thigmotaxis was used as an outcome measure contextualised to a rodent model associated with persistent pain. All studies published until the date of the search will be considered.Screening and annotationTwo independent reviewers will screen studies based on the order of (1) titles and abstracts, and (2) full texts.Data management and reportingFor meta-analysis, we will extract thigmotactic behavioural data and calculate effect sizes. Effect sizes will be combined using a random-effects model. We will assess heterogeneity and identify sources of heterogeneity. A risk-of-bias assessment will be conducted to evaluate study quality. Publication bias will be assessed using funnel plots, Egger’s regression and trim-and-fill analysis. We will also extract stimulus-evoked limb withdrawal data to assess its correlation with thigmotaxis in the same animals. The evidence obtained will provide a comprehensive understanding of the strengths and limitations of using thigmotactic outcome measure in animal pain research so that future experimental designs can be optimised. We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines and disseminate the review findings through publication and conference presentation.

Effects of sleep deprivation on maternal behaviour in animal models: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Gabriel N. Pires ◽  
Thainá B. Oliveira ◽  
Victoria F. F. Mello ◽  
Andréia G. Bezerra ◽  
Cathalijn H. C. Leenaars ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Sleep Deprivation ◽  
Meta Analysis ◽  
Maternal Behaviour

scholarly journals Efficacy of Deferoxamine in Animal Models of Intracerebral Hemorrhage: A Systematic Review and Stratified Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0127256 ◽  
Author(s):  
Han-Jin Cui ◽  
Hao-yu He ◽  
A-Li Yang ◽  
Hua-Jun Zhou ◽  
Cong Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Intracerebral Hemorrhage ◽  
Meta Analysis
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