CDK5, CRMP2 and NR2B in spinal dorsal horn and dorsal root ganglion have different role in pain signaling between neuropathic pain model and inflammatory pain model

2013 ◽  
Vol 30 ◽  
pp. 214-214 ◽  
Author(s):  
Y. Kamiya ◽  
K. Saeki ◽  
M. Takiguchi ◽  
K. Funakoshi
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Inflammatory Pain ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Pain Model ◽  
Spinal Dorsal ◽  
Neuropathic Pain Model

scholarly journals Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Enji Zhang ◽  
Min-Hee Yi ◽  
Nara Shin ◽  
Hyunjung Baek ◽  
Sena Kim ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Neuropathic Pain ◽  
Endoplasmic Reticulum Stress ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Pain Model ◽  
Spinal Dorsal ◽  
Neuropathic Pain Model

mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model

Neuroscience ◽  
2014 ◽  
Vol 275 ◽  
pp. 395-403 ◽  
Author(s):  
J. Cui ◽  
W. He ◽  
B. Yi ◽  
H. Zhao ◽  
K. Lu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Atp Release ◽  
Mtor Pathway ◽  
Astrocyte Activation ◽  
Pain Model ◽  
Spinal Dorsal ◽  
Neuropathic Pain Model

Suberoylanilide Hydroxamic Acid Triggers Autophagy by Influencing the mTOR Pathway in the Spinal Dorsal Horn in a Rat Neuropathic Pain Model

2018 ◽  
Vol 44 (2) ◽  
pp. 450-464 ◽  
Author(s):  
Xiang-Lan Feng ◽  
Hong-Bo Deng ◽  
Zheng-Gang Wang ◽  
Yun Wu ◽  
Jian-Juan Ke ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Horn ◽  
Hydroxamic Acid ◽  
Spinal Dorsal Horn ◽  
Mtor Pathway ◽  
Suberoylanilide Hydroxamic Acid ◽  
Pain Model ◽  
Spinal Dorsal ◽  
Neuropathic Pain Model

scholarly journals Regulation of Peripheral Clock to Oscillation of Substance P Contributes to Circadian Inflammatory Pain

2012 ◽  
Vol 117 (1) ◽  
pp. 149-160 ◽  
Author(s):  
Jing Zhang ◽  
Huili Li ◽  
Huajing Teng ◽  
Ting Zhang ◽  
Yonglun Luo ◽  
...  
Keyword(s):  
Substance P ◽  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Inflammatory Pain ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Luciferase Assay ◽  
Nociceptive Response ◽  
Spinal Level ◽  
Spinal Dorsal

Background The daily fluctuations of many physiologic and behavioral parameters are differentially influenced by either central or peripheral clocks in mammals. Since substance P (SP) oscillates in some brain tissues and plays an indispensable role in modulating inflammatory pain at the spinal level, we speculated that SP mediates circadian nociception transmission at the spinal level. Methods In the present study behavioral observation, real-time polymerase chain reaction, luciferase assay, chromatin immunoprecipitation, and immunohistochemistry stain methods were used to investigate the role of SP in the spinal circadian nociception transmission and its regulation mechanism. Results Our results showed that under transcriptional regulation of BMAL1:CLOCK heterodimers, SP's coding gene Tac1 expression oscillates in dorsal root ganglion (n = 36), but not in the spinal dorsal horn. Further, the expression of SP cycled in the spinal dorsal horn, and this rhythmicity was potentially determined by circadian expression of Tac1 in dorsal root ganglion. Furthermore, the variation of SP expression induced by formalin was fluctuated in a similar rhythm to behavioral nociceptive response induced by formalin (n = 48); and the nociceptive behavioral circadian rhythm could be abolished through blockade of the SP-Neurokinin 1 receptor pathway (n = 70). Lastly, the variations of spinal SP expression and behavioral nociceptive response were in step, and both were changed by the deletion mutation of clock gene. Conclusions We conclude that spinal SP probably plays a pivotal role in modulating circadian inflammatory pain and suggest that peripheral circadian-regulated signaling is potentially an essential pathway for circadian nociceptive transmission.

scholarly journals Identification of Differentially Expressed Genes by Gabapentin in Cultured Dorsal Root Ganglion in a Rat Neuropathic Pain Model

2013 ◽  
Vol 21 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Ji Hye Heo ◽  
Seung Ha Lee ◽  
Kyung Ha Chang ◽  
Eun Hye Han ◽  
Seung Gwan Lee ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Differentially Expressed Genes ◽  
Dorsal Root ◽  
Differentially Expressed ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals Neonatal vincristine administration modulates intrinsic neuronal excitability in the rat dorsal root ganglion and spinal dorsal horn during adolescence

Pain ◽  
2019 ◽  
Vol 160 (3) ◽  
pp. 645-657 ◽  
Author(s):  
Katie A. Schappacher ◽  
Wenrui Xie ◽  
Jun-Ming Zhang ◽  
Mark L. Baccei
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Neuronal Excitability ◽  
Spinal Dorsal

RETRACTED: Effects of electro-acupuncture on NT-4 expression in spinal dorsal root ganglion and associated segments of the spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomy

2009 ◽  
Vol 450 (2) ◽  
pp. 158-162 ◽  
Author(s):  
Fen Liu ◽  
Wei-Wei Sun ◽  
Ying Wang ◽  
Li-Qun Hu ◽  
Ping Dai ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Spinal Dorsal
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