Increased Risk of Bleeding in Left Ventricular Assist Device Patients Treated with Enoxaparin as Bridge to Therapeutic International Normalized Ratio

ASAIO Journal ◽  
2018 ◽  
Vol 64 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Ankit Bhatia ◽  
Colleen Juricek ◽  
Nitasha Sarswat ◽  
Sirtaz Adatya ◽  
Gene Kim ◽  
...  
2014 ◽  
Vol 3 (3) ◽  
pp. 145 ◽  
Author(s):  
Jan M Griffin ◽  
Jason N Katz ◽  
◽  

Few innovations in medicine have so convincingly and expeditiously improved patient outcomes more than the development of the left ventricular assist device (LVAD). Where optimal pharmacotherapy once routinely failed those with end-stage disease, the LVAD now offers considerable hope for the growing advanced heart failure population. Despite improvements in mortality, however, mechanical circulatory support is not without its limitations. Those supported with an LVAD are at increased risk of several complications, including infection, bleeding, stroke and arrhythmic events. While once considered benign, ventricular arrhythmias in the LVAD patient are being increasingly recognised for their deleterious influence on patient morbidity and quality of life. In addition, the often multifactorial aetiology to these episodes makes treatment difficult and optimal therapeutic management controversial. Novel strategies are clearly needed to better predict, prevent, and eradicate these arrhythmias in order to allow future generations of heart failure patients to reap the full benefits of LVAD implantation.


2017 ◽  
Vol 05 (08) ◽  
pp. E749-E753
Author(s):  
Richard Knoop ◽  
Hans-Juergen Richer-Schrag ◽  
Robert Thimme ◽  
Andreas Fischer

Abstract Background and study aims Treatment of colorectal polyps in patients undergoing permanent anticoagulation is associated with a significantly increased risk of peri-interventional bleeding. This specifically applies to polyps > 1 cm where endoscopic full-thickness resection (EFTR) with the full-thickness-resection device (FTRD) can be taken into consideration as an alternative approach to classical snare polypectomy.For these indications, EFTR appears to be superior to conventional techniques especially in terms of sufficient hemostasis due to the mechanical tissue compression achieved by the FTRDʼs integrated Over-The-Scope Clip (OTSC). This is demonstrated in the following case report of a 59-year-old male with a left ventricular assist device (LVAD) implanted due to congestive heart failure. He presented with intermittent hemorrhage from a large polyp in the ascending colon that was successfully treated via EFTR with the FTRD. A video is included.


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