Older Patients With Hepatocellular Carcinoma Have More Advanced Disease, Lower Rates of Treatment, and Lower Survival

2017 ◽  
Vol 51 (4) ◽  
pp. 378-383 ◽  
Author(s):  
Melissa Yan ◽  
John Ha ◽  
Maria Aguilar ◽  
Benny Liu ◽  
Catherine T. Frenette ◽  
...  
Drugs & Aging ◽  
2021 ◽  
Author(s):  
Antonella Cammarota ◽  
Antonio D’Alessio ◽  
Tiziana Pressiani ◽  
Lorenza Rimassa ◽  
Nicola Personeni

2015 ◽  
Vol 19 (4) ◽  
pp. 154 ◽  
Author(s):  
Ji Soo Lee ◽  
Jong Man Kim ◽  
Seunghwan Lee ◽  
Jin-Yong Choi ◽  
Wontae Cho ◽  
...  

2020 ◽  
Vol 14 (7) ◽  
pp. 37
Author(s):  
Vincent Abiodun Michael ◽  
Ismaila Adewale Bolarinwa

The research performed parametric survival analysis of Tuberculosis (TB) data (covering 2010 to 2016) collected from the Federal Medical Centre, Bida, Niger State, Nigeria. Three parametric survival models (Exponential, Weibull and Log-logistic) were fitted. The outcome variable was time to recovery from TB infection and four covariates being age, gender, TB type and occupation were involved. Models were estimated by maximum likelihood method and model selection criterion used was the Akaike Information Criterion (AIC). The exponential and log-logistic models found all covariates statistically insignificant while Weibull found all covariates but TB type significant at 5% level. Based on AIC, Weibull model with AIC of 163.5731 performed best, followed by log-logistic model with AIC of 191.419 and exponential model performed worst, with AIC of 517.9652. The best of fitted models being Weibull suggested that older patients had higher hazards than younger ones, older patients hence, had lower survival times, holding other covariates constant. That is, the older the TB patient, the lower was the time to recovery from TB. Males had higher hazards and hence, lower survival times compared to females. That is, male TB patients recovered faster than the females. Pulmonary TB patients had lower (insignificant) hazards and hence, higher survival times than Respiratory TB patients. TB patients on technical occupation had lower hazards than others and hence, had higher survival times than those whose occupations were considered not technical. The research concluded that age, gender and occupation were the major determinants of recovery period of TB patients. It was recommended that the Management of Federal Medical Centre, Bida, and other organizations involved in TB management could make use of the Weibull model to fit and predict both the survival and hazard rates of TB patients.


Author(s):  
Davide Ghinolfi ◽  
Erion Rreka ◽  
Daniele Pezzati ◽  
Franco Filipponi ◽  
Paolo De Simone

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Guoyong Chen ◽  
Jiabin Zhang ◽  
Jianjun Sun ◽  
Sidong Wei ◽  
Jianbin Chen ◽  
...  

Author(s):  
Motaz Qadan ◽  
Nishita Kothary ◽  
Bruno Sangro ◽  
Manisha Palta

Hepatocellular carcinoma (HCC) is the sixth most common cancer and third leading cause of cancer-related death worldwide. HCC is also is a tumor with a distinct ability to invade and grow within the hepatic vasculature. Approximately 20% of patients with HCC have macrovascular invasion (MVI) at the time of diagnosis. MVI is associated with dismal prognosis, with median survival ranging from 2 to 5 months. Current staging systems designate MVI as advanced disease. Recent advances in multimodal approaches, including systemic therapies, radiation therapy, liver-directed therapies, and surgical approaches, in the treatment of HCC with MVI have rendered this disease process more treatable with improved outcomes and are discussed here.


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