scholarly journals Association between serum 25-hydroxyvitamin D and carotid atherosclerotic plaque in Chinese type 2 diabetic patients

Medicine ◽  
2017 ◽  
Vol 96 (13) ◽  
pp. e6445 ◽  
Author(s):  
Ya-Hui Ding ◽  
Tie-Ming Wei ◽  
Lin-Yan Qian ◽  
Yuan Ma ◽  
Di-Bo Lao ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Diabetic Patients ◽  
Carotid Atherosclerotic Plaque ◽  
Type 2 Diabetic Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Type 2 Diabetic

scholarly journals Correlational study on the levels of 25-hydroxyvitamin D and non-alcoholic fatty liver disease in type 2 diabetic patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuanyuan Zhang ◽  
Juyi Li ◽  
Yingqun Ni ◽  
Yan Wang ◽  
Huaizhen Liu
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Type 2 Diabetic

Abstract Background It is widely acknowledged that nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM) are all chronic metabolic diseases. The objective of this study is to retrospectively probe the association between the 25-hydroxyvitamin D (25-(OH)D) and NAFLD in type 2 diabetic patients. Methods Three hundred thirty-nine T2DM patients participated in this research and from November 2018 to September 2019 and were divided into simple T2DM group (108 cases) and T2DM with NAFLD group (231 cases) in conformity with abdominal ultrasound diagnosis. The NAFLD fibrosis score (NFS) ≥0.676 was defined as progressive liver fibrosis.231 T2DM with NAFLD patients were categorized into two subgroups: progressive liver fibrosis subgroup (48 cases) and without progressive liver fibrosis subgroup (183 cases). Results The prevalence of NAFLD by Abdominal ultrasonography was 68%.The results indicated that the levels of 25-(OH) D were significantly lower in T2DM with NAFLD group than that in simple T2DM group(P < 0.01). The levels of 25-(OH) D were significantly lower in progressive liver fibrosis subgroup than that in patients without progressive liver fibrosis and simple T2DM,and 25-(OH) D levels were lower in without progressive liver fibrosis subgroup than that in simple T2DM group(p < 0.01 or p < 0.05). Multivariate logistic regression analysis showed that levels of 25-(OH) D were negative correlation with risk of NAFLD and progressive liver fibrosis(p = 0.011、p = 0.044,respectively). Conclusions we could come to a conclusion that low levels of 25-(OH) D was a risk factor for NAFLD and progressive liver fibrosis in T2DM patients.

scholarly journals Correlational study on the levels of 25-hydroxyvitamin D and non-alcoholic fatty liver disease in type 2 diabetic patients

2021 ◽  
Author(s):  
Zhang Yuanyuan ◽  
Juyi Li ◽  
Yingqun Ni ◽  
Yan Wang ◽  
Huaizhen Liu
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Type 2 Diabetic

Abstract Background It is widely acknowledged that nonalcoholic fatty liver disease(NAFLD) and type 2 diabetes mellitus(T2DM) are all chronic metabolic diseases.The objective of this study is to retrospectively probe the association between the 25-hydroxyvitamin D(25-(OH)D) and NAFLD in type 2 diabetic patients. Methods 339 T2DM patients participated in this research and from November 2018 to September 2019 and were divided into simple T2DM group(108 cases) and T2DM with NAFLD group(231 cases) in conformity with abdominal ultrasound diagnosis. The NAFLD fibrosis score (NFS) ≥ 0.676 was defined as progressive liver fibrosis.231 T2DM with NAFLD patients were categorized into two subgroups: progressive liver fibrosis subgroup(48 cases) and without progressive liver fibrosis subgroup(183 cases). Results The prevalence of NAFLD by Abdominal ultrasonography was 68%.The results indicated that the levels of 25-(OH)D were significantly lower in T2DM with NAFLD group than that in simple T2DM group(P < 0.01).The levels of 25-(OH)D were significantly lower in progressive liver fibrosis subgroup than that in patients without progressive liver fibrosis and simple T2DM,and 25-(OH)D levels were lower in without progressive liver fibrosis subgroup than that in simple T2DM group(p < 0.01 or p < 0.05).Multivariate logistic regression analysis showed that levels of 25-(OH)D were negative correlation with risk of NAFLD and progressive liver fibrosis(p = 0.011、p = 0.044,respectively). Conclusions we could come to a conclusion that low levels of 25-(OH)D was a risk factor for NAFLD and progressive liver fibrosis in T2DM patients.

scholarly journals Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Yurong Wang ◽  
Huijuan Zhang
Keyword(s):  
Regression Analysis ◽  
Atherosclerotic Plaque ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Carotid Atherosclerotic Plaque ◽  
Type 2 Diabetic Patients ◽  
Carotid Imt ◽  
Type 2 Diabetic

Objective.To investigate the relationship between serum 25-hydroxyvitamin D3 [25(OH)D3] levels and carotid intima-media thickness (IMT) as well as carotid atherosclerotic plaque in patients with type 2 diabetes mellitus (T2DM).Methods.314 patients with T2DM were enrolled in this study. The clinical data and laboratory examinations of subjects were recorded, such as serum 25(OH)D3, hemoglobin A1c (HbA1c), serum lipids, fasting blood glucose (FBG), and other biochemical parameters. Color Doppler ultrasound was used to measure carotid IMT and carotid atherosclerotic plaques. Patients were divided into four quartile groups according to the serum 25(OH)D3 levels from low to high: group Q1~group Q4.Results.From group Q1 to group Q4, carotid IMT and the incidence of plaque were gradually reduced. Serum 25(OH)D3 levels were lower in the plaque group compared with the nonplaque group (P<0.01). Serum 25(OH)D3 levels were negatively correlated with the carotid IMT (r=−0.4,P<0.01). Multiple linear stepwise regression analysis showed that serum 25(OH)D3 was independently associated with carotid IMT (β=−0.009,P<0.01). Logistic regression analysis showed that serum 25(OH)D3 levels were independently associated with the presence of carotid plaque in T2DM (OR = 0.95; 95%CI: 0.92~0.98,P=0.004).Conclusions.Low vitamin D status may contribute to the incidence of carotid atherosclerosis in type 2 diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document