Large tumor size is a poor prognostic factor of gastric cancer with signet ring cell

Introduction: There have been few studies about gene differences between patients with diffuse-type gastric cancer and those with intestinal-type gastric cancer. The aim of this study was to compare the transcriptomes of signet ring cell gastric cancer (worst prognosis in diffuse-type) and well-differentiated gastric cancer (best prognosis in intestinal-type); NUDC was identified, and its prognostic role was studied. Materials and Methods: We performed next-generation sequencing with 5 well-differentiated gastric cancers and 3 of signet ring cell gastric cancer surgical samples. We performed gene enrichment and functional annotation analysis using the Database for Annotation, Visualization and Integrated Discovery bioinformatics resources. Immunohistochemistry was used to validate NUDC expression. Results: Overall, 900 genes showed significantly higher expression, 644 genes showed lower expression in signet ring cell gastric cancer than in well-differentiated gastric cancers, and there was a large difference in adhesion, vascular development, and cell-to-cell junction components between the 2 subtypes. We performed variant analysis and found 52 variants and 30 cancer driver genes, including NUDC. We analyzed NUDC expression in gastric cancer tissue and its relationship with prognosis. Cox proportional hazard analysis identified T stage, N stage, and NUDC expression as independent risk factors for survival ( P < 0.05). The overall survival of the NUDC-positive group was significantly higher (53.2 ± 0.92 months) than that of the NUDC-negative group (44.6 ± 3.7 months) ( P = 0.001) in Kaplan-Meier survival analysis. Conclusion: We found 30 cancer driver gene candidates and found that the NUDC-positive group showed significantly better survival than the NUDC-negative group via variant analysis.

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Optimal care and survival for signet-ring cell and non-signet-ring cell gastric cancer are more achievable at academic cancer centers

The American Journal of Surgery ◽

10.1016/j.amjsurg.2021.05.007 ◽

2021 ◽

Author(s):

Maitham A. Moslim ◽

Mengying Deng ◽

Elizabeth Handorf ◽

Stephanie H. Greco ◽

Jeffrey M. Farma

Keyword(s):

Gastric Cancer ◽

Signet Ring Cell ◽

Optimal Care ◽

Cancer Centers ◽

Signet Ring ◽

Ring Cell

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Standard of Care and Survival for Signet-ring Cell and Non-Signet-ring Cell Gastric Cancer are More Achievable at Academic Cancer Centers

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2020.11.209 ◽

2021 ◽

Vol 47 (2) ◽

pp. e25

Author(s):

Maitham Moslim ◽

M. Deng ◽

E. Handorf ◽

S. Greco ◽

S. Reddy ◽

...

Keyword(s):

Gastric Cancer ◽

Standard Of Care ◽

Signet Ring Cell ◽

Cancer Centers ◽

Signet Ring ◽

Ring Cell

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Comparison of 68Ga-FAPI-04 and 18F-FDG for the Detection of Primary Gastric Cancers and Metastasis

10.21203/rs.3.rs-326617/v1 ◽

2021 ◽

Author(s):

Donglang Jiang ◽

Xing Chen ◽

Zhiwen You ◽

Hao Wang ◽

Xiaoyun Zhang ◽

...

Keyword(s):

Gastric Cancer ◽

Cell Carcinoma ◽

Cancer Diagnosis ◽

Fdg Pet ◽

Standardized Uptake Value ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Gastric Cancers ◽

Signet Ring ◽

Ring Cell

Abstract Introduction Early and precise diagnosis and staging of gastric cancer are important for its treatment and management. However, the low sensitivity of 18F-fluorodeoxyglucose (18F-FDG) for gastric cancer diagnosis limits its application. Currently, the tracer 68Ga-FAPI, which targets fibroblast activation protein (FAP), is widely used to diagnose various cancers. However, the diagnostic value of 68Ga-FAPI in gastric cancer is still unclear. In this study, we aimed to investigate the potential advantage of 68Ga-FAPI-04 over 18F-FDG in the evaluation of gastric cancer.Methods: Thirty-eight patients with gastric cancer (31 with adenocarcinoma and 7 with signet ring cell carcinoma) were recruited for this study. All of the participants underwent 68Ga-FAPI-04 and 18F-FDG imaging by positron emission tomography (PET)/computed tomography (CT) or PET/magnetic resonance (MR). The results were interpreted by two experienced nuclear medicine physicians, and the maximum standardized uptake value (SUVmax) was calculated.Results: For the detection of primary gastric cancer, the sensitivities of 68Ga-FAPI-04 PET and 18F-FDG PET were 100% (38/38) and 81.6% (31/38), respectively. Four cases of adenocarcinoma and three cases of signet ring cell carcinoma were missed by 18F-FDG PET. The SUVmax of 68Ga-FAPI-04 in tumors greater than 4 cm (11.0 ± 4.5) was higher than tumors less than 4 cm (4.5 ± 3.2) (P = 0.0015). The SUVmax of 68Ga-FAPI-04 was higher in T2-4 tumors (9.7 ± 4.4) than in T1 tumors (3.1 ± 1.5) (P = 0.0002). For the detection of metastatic lesions, the sensitivities of 68Ga-FAPI-04 PET and 18F-FDG PET in 10 patients with regional lymph node metastasis and distant metastasis were 6/10 and 5/10, respectively.Conclusion: Compared to 18F-FDG PET, 68Ga-FAPI-04 PET had superior potential in detecting primary gastric cancers and metastatic lymph nodes, 68Ga-FAPI-04 PET also had a better performance on small gastric cancer detection. 68Ga-FAPI-04 PET could provide better performance for gastric cancer diagnosis and staging.

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Wernicke Encephalopathy Due to Prolonged Total Parenteral Nutrition in A Child with Signet Ring Cell Gastric Carcinoma

10.38092/jpa-2020-7 ◽

2020 ◽

pp. 30-33

Author(s):

Buket KARA ◽

Ayse KARTAL ◽

Mehmet ÖZTÜRK ◽

Yavuz KÖKSAL

Keyword(s):

Gastric Cancer ◽

Gastric Carcinoma ◽

Parenteral Nutrition ◽

Total Parenteral Nutrition ◽

Signet Ring Cell ◽

Diffuse Gastric Cancer ◽

Wernicke Encephalopathy ◽

Signet Ring ◽

Ring Cell

Signet ring cell gastric carcinoma is extremely rare during childhood. One of the most important problems in these patients is nutritional difficulty and impairment, and these patients are often supported by total parenteral nutrition. Herein, the authors report a case of Wernicke encephalopathy due to prolonged total parenteral nutrition in a 13-year-old girl with diffuse gastric cancer with signet ring cell.

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Prognostic Significance of EMVI in Rectal Cancer in a Tertiary Cancer Hospital in India

Indian Journal of Radiology and Imaging ◽

10.1055/s-0041-1736404 ◽

2021 ◽

Author(s):

Sayali Y. Pangarkar ◽

Akshay D. Baheti ◽

Kunal A. Mistry ◽

Amit J. Choudhari ◽

Vasundhara R. Patil ◽

...

Keyword(s):

Rectal Cancer ◽

Distant Metastasis ◽

Locally Advanced ◽

Prognostic Significance ◽

Signet Ring Cell ◽

Poor Prognostic Factor ◽

Free Survival ◽

Signet Ring ◽

Rectal Cancers ◽

Ring Cell

Abstract Background Presence of extramural venous invasion (EMVI) is a poor prognostic factor for rectal cancer as per literature. However, India-specific data are lacking. Aim The aim of the study is to determine the prognostic significance of EMVI in locally advanced rectal cancer on baseline MRI. Materials and Methods We retrospectively reviewed 117 MRIs of operable non-metastatic locally advanced rectal cancers in a tertiary cancer institute. Three dedicated oncoradiologists determined presence or absence of EMVI, and its length and thickness, in consensus. These patients were treated as per standard institutional protocols and followed up for a median period of 37 months (range: 2–71 months). Kaplan-Meier curves (95% CI) were used to determine disease-free survival (DFS), distant-metastases free survival (DMFS), and overall survival (OS). Univariate analysis was performed by comparing groups with log-rank test. Results EMVI positive cases were 34/114 (29%). More EMVI-positive cases developed distant metastasis compared with EMVI-negative cases (14/34–41% vs. 22/83–26%). The difference, however, was not statistically significant (p = 0.146). After excluding signet-ring cell cancers (n = 14), EMVI showed significant correlation with DMFS (p = 0.046), but not with DFS or OS. The median thickness and length of EMVI was 6 and 14 mm, respectively in patients who developed distant metastasis, as compared with 5 and 11 mm in those who did not, although this difference was not statistically significant. Conclusion EMVI is a predictor of distant metastasis in locally advanced non-metastatic, non-signet ring cell rectal cancers. EMVI can be considered another high-risk feature to predict distant metastasis.

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