Healing of Erosive Esophagitis and Improvement of Symptoms of Gastroesophageal Reflux Disease After Esomeprazole Treatment in Children 12 to 36 Months Old

2015 ◽  
Vol 60 ◽  
pp. S31-S36 ◽  
Author(s):  
Vasundkara Tolia ◽  
Mark A. Gilger ◽  
Peter N. Barker ◽  
Marta Illueca
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Erosive Esophagitis

scholarly journals Dexlansoprazole MR in the Management of Gastroesophageal Reflux Disease

2009 ◽  
Vol 1 ◽  
pp. CMT.S2538
Author(s):  
Keith M. Olsen ◽  
Margaret L. Hitzeman
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Residence Time ◽  
Reflux Disease ◽  
Plasma Concentrations ◽  
Erosive Esophagitis ◽  
Release Mechanism ◽  
Percent Time ◽  
New Treatment ◽  
Gastrointestinal Adverse Events

Dexlansoprazole MR, an enantiomer of lansoprazole, is a unique proton pump inhibitor with a duel release mechanism. This release mechanism produces two distinct peak concentrations that result in a prolonged mean residence time with increased duration of plasma concentrations and a greater percent time the pH is maintained above 4. The prolonged residence time allows dexlansoprazole MR to be administered throughout the day without regards to meals or the timing before a meal. In two trials of patients with erosive esophagitis, dexlansoprazole MR 60 mg and 90 mg demonstrated comparable healing rates to lansoprazole 30 mg. In patients with healed EE, dexlansoprazole MR 30 mg (75%) and 60 mg (83%) were superior to placebo (27%; p < 0.0025) in maintenance of healing. Dexlansoprazole MR 30 mg and 60 mg had a greater pecentage of heartburn-free days (91%-96%) and heartburn-free nights (96%-99%) than placebo (29%-72%) over the 6-month maintenance trial. Dexlansorpazole MR appears to be well tolerated with the safety profile being similar to lansoprazole with gastrointestinal adverse events being the most common. Dexlansoprazole MR provides a new treatment option for gastroesophageal reflux disease due to the flexible dosing, the unique release mechanisms and prologned pharmacodynamic effect.

TREATMENT OF EROSIVE ESOPHAGITIS WITH ESOMEPRAZOLE IN CHILDREN WITH GASTROESOPHAGEAL REFLUX DISEASE

2006 ◽  
Vol 43 (4) ◽  
pp. E20 ◽  
Author(s):  
Vasundhara Tolia ◽  
Nader Youssef ◽  
William Belknap ◽  
Mark Gilger ◽  
Barry Traxler ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Erosive Esophagitis

scholarly journals ENDOSCOPIC CHANGES RELATED TO GASTROESOPHAGEAL REFLUX DISEASE: COMPARATIVE STUDY AMONG BARIATRIC SURGERY PATIENTS

2015 ◽  
Vol 28 (suppl 1) ◽  
pp. 36-38 ◽  
Author(s):  
Marco Aurelio SANTO ◽  
Sylvia Regina QUINTANILHA ◽  
Cesar Augusto MIETTI ◽  
Flavio Masato KAWAMOTO ◽  
Allan Garms MARSON ◽  
...  
Keyword(s):  
Los Angeles ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Hiatal Hernia ◽  
Barrett’S Esophagus ◽  
Reflux Disease ◽  
Barrett's Esophagus ◽  
Erosive Esophagitis ◽  
Los Angeles Classification ◽  
Bariatric Patients

Background : Obesity is correlated with several comorbidities, including gastroesophageal reflux disease. Its main complications are detectable by endoscopy: erosive esophagitis and Barrett's esophagus. Aim : To correlate erosive esophagitis and hiatal hernia with the degree of body mass index (BMI). Method : Was performed a retrospective analysis of 717 preoperative endoscopic reports of bariatric patients. Fifty-six (8%) presented hiatal hernia, being 44 small, nine medium and five large. Esophagitis was classified by Los Angeles classification. Results : There was no correlation between the presence and dimension of hiatal hernia with BMI. One hundred thirty-four (18.7%) patients presented erosive esophagitis. Among them, 104 (14.5%) had esophagitis grade A; 25 (3.5%) grade B; and five (0.7%) grade C. When considering only the patients with erosive esophagitis, 77.6% had esophagitis grade A, 18.7% grade B and 3.7% grade C. Were identified only two patients with Barrett's esophagus (0,28%). Conclusion : There was a positive correlation between the degree of esophagitis with increasing BMI.

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