scholarly journals Balance performance in patients with post-acute COVID-19 compared to patients with an acute exacerbation of chronic obstructive pulmonary disease and healthy subjects

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Marica Giardini ◽  
Ilaria Arcolin ◽  
Simone Guglielmetti ◽  
Marco Godi ◽  
Armando Capelli ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Healthy Subjects ◽  
Chronic Obstructive ◽  
Balance Performance ◽  
Obstructive Pulmonary Disease

scholarly journals High-coverage Lipidomics Analysis Reveals Biomarkers for Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Two Traditional Chinese Medicine Syndromes

2021 ◽  
Author(s):  
Xin-guang Liu ◽  
Hai-Long Zhang ◽  
Yi-Mei Si ◽  
Yan Du ◽  
Jin-Yan Wu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Chinese Medicine ◽  
Early Diagnosis ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Healthy Subjects ◽  
Chronic Obstructive ◽  
High Coverage ◽  
Obstructive Pulmonary Disease ◽  
Stable Stage

Abstract BackgroundTraditional Chinese medicine (TCM) is distinguished by syndrome differentiation. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the leading cause of morbidity and mortality in COPD management. Previous studies have proved that AECOPD can be characterized as 2 TCM syndromes, and systematic dialectical treatment showed better curative effect than conventional therapy. However, detecting the progression from the stable stage to acute exacerbation of COPD with different TCM syndromes mainly depends on doctors’ judgment of clinical symptoms, and there is no biomarker that can be used for auxiliary clinical diagnosis. This study conducted a high-coverage lipidomics to find biomarker for the early diagnosis of AECOPD with 2 TCM syndromes.MethodsSerum samples from COPD patients (n=82) and healthy subjects (n=29) were collected and analyzed. Patients with COPD were divided into stable COPD (SCOPD) and AECOPD groups, with the latter comprising TCM syndromes: phlegm–heat congesting lung (PH-CL) and phlegm-damp amassing in the lung (PD-AL). High-coverage lipidomics profiling of 913 lipids belonging to 19 subclasses was carried out by liquid chromatography–quadrupole orbitrap mass spectrometry.ResultsWe performed 4 cross-comparisons to characterize metabolic disturbances associated with the progression of stable COPD to AECOPD—ie, SCOPD vs healthy subjects, AECOPD vs SCOPD, PH-CL-AECOPD vs SCOPD, and PD-AL-AECOPD vs SCOPD. We identified 86 lipids with differential abundance among groups. Lipids that were altered from the stable stage of disease to AECOPD included sphingolipids, ether-containing glycerophospholipids, phosphatidylglycerols, and glycerol lipids. Three panels of lipid biomarkers specific to AECOPD, two TCM syndromes of AECOPD vs SCOPD yielded areas under the receiver operating characteristic curve of 0.788, 0.921 and 0.920, respectively, with sensitivity of 77.5%, 80.7% and 91.3%, respectively, and specificity of 75.8%, 97.0% and 87.9%, respectively.ConclusionsDifferences in lipid metabolism may underlie AECOPD and its TCM syndromes, and can serve as biomarkers for early diagnosis.

Invasive-noninvasive Sequential Ventilation for the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 22 (3) ◽  
pp. 160-168
Author(s):  
Jian-Da Huang ◽  
Tong-Jie Gu ◽  
Zhi-Lin Hu ◽  
Dan-Fei Zhou ◽  
Jun Ying
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Length Of Stay ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Relevant Literature ◽  
Total Duration ◽  
Chronic Obstructive ◽  
Invasive Ventilation ◽  
Obstructive Pulmonary Disease ◽  
Relative Risks

Background: The study aimed to evaluate the efficacy and safety of invasivenoninvasive sequential ventilation versus invasive ventilation in the treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). Method: PubMed, Cochrane, Embase, Wanfang, CNKI, VIP database were searched by the index words to identify the qualified RCTs, and relevant literature sources were also searched. The latest research was conducted in June 2017. Relative Risks (RR), and Mean Difference (MD) along with 95% confidence interval (95% CI) were used to analyze the main outcomes. Result: Twenty-nine RCTs were involved in this analysis of 1061 patients in the invasivenoninvasive sequential ventilation group (In-non group) and 1074 patients in the invasive ventilation group (In group). The results indicated that compared with the invasive ventilation, invasive-noninvasive sequential ventilation would significantly decrease the incidence of VAP (RR:0.20, 95%CI: 0.16-0.26), mortality (RR:0.38, 95%CI: 0.26-0.55), reintubation (RR:0.39, 95%CI: 0.27-0.55); and statistically reduced the duration of invasive ventilation (MD:-9.23, 95%CI: -10.65, -7.82), the total duration of mechanical ventilation (MD:-4.91, 95%CI: -5.99, -3.83), and the length of stay in the ICU (MD:-5.10, 95%CI: -5.43, -4.76). Conclusion: The results demonstrated that the application of noninvasive sequential ventilation after invasive ventilation at the pulmonary infection control window has a significant influence on VAP incidence, mortality, and the length of stay in the ICU, but further well-designed, adequately powered RCTs are required to validate the conclusion.

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