O2 Physisorption in Coal Pore: Effects of Pore Size, Pressure, Temperature and Function Group

In this paper, the physical adsorption characteristics of oxygen in coal pores were systematically investigated by the Grand Canonical Monte Carlo and the COMPASS force field. Firstly, coal pore structures of different sizes were constructed by graphite slit models and different groups. Secondly, the physisorption behavior of oxygen in graphite slit models of different sizes was simulated. Finally, the physisorption behavior of oxygen in graphite slit models at different pressures and temperatures was analyzed. The results showed that the physisorption density and excess physical adsorption of oxygen were divided into the rapidly decreasing stage (0.4-0.7 nm), the slowly decreasing stage (0.7-1.4 nm), and the stable stage (1.4 nm-5 nm) with the increase of coal pores, and the excess oxygen physisorption amount was more sensitive to the change of pressure. The O2 isosteric heat of physisorption decreased with increasing pore size of coal. Oxygen is more strongly adsorbed by hydroxyl and ether bonds than by methyl, carboxyl and carbonyl groups. Through this study, the mechanism of oxygen physical adsorption in coal pores and the characteristics influenced by temperature and pressure can be better understood.

Study on Metabolic Indexes of Obesity in Patients with Common Mental Disorders in Stable Stage

Background The incidence rate of obesity has been increasing steadily year by year, and it is a serious worldwide public health problem，especially for people with mental disorders.Aim To explore the related factors of obesity by analyzing the metabolic indexes of patients with common mental disorders in stable stage. Methods 576 subjects with major depressive disorder (MDD), bipolar disorder (BD) or schizophrenia (SCZ) were included, who received fixed drug dose and routine drug treatment for 2 years or more. Their venous blood was collected, and the blood metabolic indexes were analyzed. Results BD and SCZ are more prone to obesity than MDD. Multiple linear regression analysis showed that the value of BMI increased with the increase of age(B = 0.084, p < 0.001), TG(B = 0.355, p = 0.024), LDL(B = 0.697, p < 0.001), LDH(B = 0.011, p = 0.002), SCr(B = 0.051, p < 0.001), UA(B = 0.014, p < 0.001), HbA1c(B = 0.702, p = 0.004) and hsCRP(B = 0.101, p < 0.001). And It decreased with the increase of HDL(B = -1.493, p < 0.001). Discussion People with mental disorders who take drugs are prone to obesity. They should regularly check blood indicators and strengthen weight management to reduce the risk of obesity and promote their health.

High-coverage Lipidomics Analysis Reveals Biomarkers for Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Two Traditional Chinese Medicine Syndromes

BackgroundTraditional Chinese medicine (TCM) is distinguished by syndrome differentiation. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the leading cause of morbidity and mortality in COPD management. Previous studies have proved that AECOPD can be characterized as 2 TCM syndromes, and systematic dialectical treatment showed better curative effect than conventional therapy. However, detecting the progression from the stable stage to acute exacerbation of COPD with different TCM syndromes mainly depends on doctors’ judgment of clinical symptoms, and there is no biomarker that can be used for auxiliary clinical diagnosis. This study conducted a high-coverage lipidomics to find biomarker for the early diagnosis of AECOPD with 2 TCM syndromes.MethodsSerum samples from COPD patients (n=82) and healthy subjects (n=29) were collected and analyzed. Patients with COPD were divided into stable COPD (SCOPD) and AECOPD groups, with the latter comprising TCM syndromes: phlegm–heat congesting lung (PH-CL) and phlegm-damp amassing in the lung (PD-AL). High-coverage lipidomics profiling of 913 lipids belonging to 19 subclasses was carried out by liquid chromatography–quadrupole orbitrap mass spectrometry.ResultsWe performed 4 cross-comparisons to characterize metabolic disturbances associated with the progression of stable COPD to AECOPD—ie, SCOPD vs healthy subjects, AECOPD vs SCOPD, PH-CL-AECOPD vs SCOPD, and PD-AL-AECOPD vs SCOPD. We identified 86 lipids with differential abundance among groups. Lipids that were altered from the stable stage of disease to AECOPD included sphingolipids, ether-containing glycerophospholipids, phosphatidylglycerols, and glycerol lipids. Three panels of lipid biomarkers specific to AECOPD, two TCM syndromes of AECOPD vs SCOPD yielded areas under the receiver operating characteristic curve of 0.788, 0.921 and 0.920, respectively, with sensitivity of 77.5%, 80.7% and 91.3%, respectively, and specificity of 75.8%, 97.0% and 87.9%, respectively.ConclusionsDifferences in lipid metabolism may underlie AECOPD and its TCM syndromes, and can serve as biomarkers for early diagnosis.

Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in humans and remains to have a fatal prognosis. Recent studies in animal models and human ALS patients indicate that increased reactive oxygen species (ROS) play an important role in the pathogenesis. Considering previous studies revealing the influence of ROS on mitochondrial physiology, our attention was focused on mitochondria in the murine ALS model, wobbler mouse. The aim of this study was to investigate morphological differences between wild-type and wobbler mitochondria with aid of superresolution structured illumination fluorescence microscopy, TEM, and TEM tomography. To get an insight into mitochondrial dynamics, expression studies of corresponding proteins were performed. Here, we found significantly smaller and degenerated mitochondria in wobbler motor neurons at a stable stage of the disease. Our data suggest a ROS-regulated, Ox-CaMKII-dependent Drp1 activation leading to disrupted fission-fusion balance, resulting in fragmented mitochondria. These changes are associated with numerous impairments, resulting in an overall self-reinforcing decline of motor neurons. In summary, our study provides common pathomechanisms with other ALS models and human ALS cases confirming mitochondria and related dysfunctions as a therapeutic target for the treatment of ALS.

Utilization of the Tiktok Video Application as a Means of Showing Existence And Self-Disclosure of Teenagers on Social Media

Along with the rapid development of technology, the current use of social media by the community is also increasing. One of the social media that is currently on the rise is the TikTok application. TikTok application users come from various backgrounds and ages, including teenagers. Video-based TikTok features accompanied by music, writing, and pictures are considered attractive so that they are liked by teenagers as a means of showing their existence and self-disclosure. TikTok is also currently developing as a way to share information. The theory applied by the researcher was Alman and Taylor's Social Penetration Theory. In addition to such theory, this paper are supported and strengthened by the concepts of Self-Disclosure, Social Media, Teenagers, TikTok, and also Self-Existence. This paper was a qualitative descritpive study which applied a qualitative study method. This paper involved several informants namely teenagers who were also the users of the TikTok application. The inclusion criteria here were teenagers who had a TikTok account, were active on TikTok, and used TikTok as part of their existence and self-disclosure. The results of this study explored the process of self-disclosure and also the existence carried out by the informants in accordance with the stages proposed in the social penetration theory. Informants passed through the stages of self-disclosure sequentially from the orientation stage to the stable stage so that the existence of teenagers in presenting themselves on social media could be observed.

Study of the electrophysiological mechanisms of anticonvulsant action of the original levetiracetam analog the compound GIZH-290

The study used the method of cobalt epilepsy, which allows rats with long-term implanted electrodes in the cortical and subcortical structures of the brain to monitor the dynamics of the formation and migration of Epi-foci for a long time. It was found that in the control at the 1st stage of development of the Epi system, Epi activity is most pronounced in the electrocorticograms of the ipsilateral cortex, and at the 2nd, stable stage of development of the Epi system – in the contralateral cortex and subcortical structures. The compound GIZH-290 (the original structural analogue of levetiracetam) reduces the number of Epi discharges and their duration at the 2nd, stable stage of the development of the Epi system. The target structure of the GIZH – 290 compound was the hippocampus. The compound GIZH -290 selectively statistically significantly reduces both the number and duration of Epi – discharges only in the hippocampus and does not affect the foci of epileptic activity in the ipsi-and contralateral cortex and hypothalamus.

The secrets to domestic bliss – Partner fidelity and environmental filtering preserve stage-specific turtle ant gut symbioses for over 40 million years

BackgroundGut microbiomes can vary across development, a pattern often found for insects with complete metamorphosis. With varying nutritional need and distinct opportunities for microbial acquisition, questions arise as to how such ‘holometabolous’ insects retain helpful microbes at larval and adult stages. Ants are an intriguing system for such study. In a number of lineages adults digest only liquid food sources, while larvae digest solid foods. Like some other social insects, workers and soldiers of some ant species engage in oral-anal trophallaxes, enabling microbial transfer among siblings. But do queens, the typical colony founding caste, obtain symbionts through such transfer? Does this enable transgenerational symbiont passage? And does the resulting partner fidelity promote the evolution of beneficial symbionts? Furthermore, how might such adult-centric biology shape larval microbiomes? To address these questions, we characterized symbiotic gut bacteria across 13 species of Cephalotes turtle ants, with up to 40-million years of divergence. Adding to the prior focus on workers we, here, study underexplored castes and stages including queens, soldiers, and larvae, by performing 16S rRNA qPCR, amplicon sequencing, and phylogenetic classification.ResultsWe show that adult microbiomes are conserved across species and largely across castes. Nearly 95% of the bacteria in adults have, thus far, been found only in Cephalotes ants. Furthermore, the microbiomes from most adults exhibit phylosymbiosis, a trend in which microbiome community similarity recapitulates patterns of host relatedness. Additionally, an abundant, adult-enriched symbiont cospeciates with some Cephalotes. Evidence here suggests that these partner fidelity patterns extend from transgenerational symbiont transfer through alate gyne dispersal and subsequent colony-founding by queens. Like adults, larvae of Cephalotes species exhibit strong microbiome conservation. Phylosymbiosis patterns are weaker, however, with further evidence elevating environmental filtering as a primary mechanism behind such conservation. Specifically, while adult-enriched symbionts are found in most larvae, symbionts of older larvae are highly related to free-living bacteria from the Enterobacteriaceae, Lactobacillales, and Actinobacteria.ConclusionsOur findings suggest that both partner fidelity and conserved environmental filtering drive stable, stage-specific, social insect symbioses. We discuss the implications for our broader understanding of insect microbiomes, and the means of sustaining a beneficial microbiome.

Penetration Damaging Behavior of ATI425 Titanium Alloy

The penetration damaging behavior of ATI425 titanium alloy was studied by 7.62 mm diameter armor piercing projectiles. The damage characteristics and the mechanism were analyzed by observing and analyzing the craters of ATI425 titanium alloy target. It can be found that local temperature-rise of the target plate occurred, even sputtering phenomenon in the opening stage. The shear bands extended upward along the cater wall could be seen in the stable stage. The large non-homogeneous deformation in adiabatic shear bands caused microcracks and micropores. A large number of macro-cracks were observed on the side wall and at the bottom of the crater.

Digital economy and its key indicators in the analysis

The main purpose of the study is to assess the impact of digitalization on the labor market. The study examines four indices that are widely used in international practice. Also, the current state of digitalization in the Republic of Azerbaijan and its comparison with the CIS and other countries was analyzed. The results show that Azerbaijan is in a stable stage of development in the new stage of the industrial revolution. Key words: industrial revolution, digitalization, technological development, digital economy, innovations, production automation

Analysis of Re-Tensioning Time of Anchor Cable Based on New Prestress Loss Model

Considering the interaction among anchor cable, frame beam and rock mass, a new model of prestress loss of anchor cable was established. The accuracy and applicability of the new model were verified by comparing the field monitoring data and the calculation results of existing models. In addition, based on the new model, the effect of the re-tension of the anchor cable at different time nodes was analyzed, and the later compensation time of anchor cable prestress was discussed. The research shows that: the accuracy of the new model is higher after considering the effect of the frame beam, the new model can not only calculate the loss of prestress of anchor cable, but also accurately predict the time when the prestress of anchor cable reaches the stable stage. The ideal effect of prestress compensation can be achieved when the anchor cable is re-tensioned at each time point after 20 days of the construction completed. The original prestress loss of the anchor cable is different, and the re-tension effect is also different, the greater the loss of the original prestress of the anchor cable, the more obvious the prestress compensation effect during the re-tension.