The Histology and Management of Ovarian Cysts Found in Children and Adolescents Presenting to a Children’s Hospital From 1991 to 2007: A Call for More Pediatric Gynecologists

9502 Background: To evaluate the efficacy of 12 weeks of Stanford V chemotherapy (prednisone, vinblastine, doxorubicine, nitrogen mustard, etoposide, vincristine, and bleomycin) without routine growth factor support plus response-adapted low-dose, involved-field radiotherapy (IFRT) in children and adolescents with unfavorable risk Hodgkin lymphoma (HL). Methods: Multi-institutional (St. Jude Children’s Research Hospital, Stanford University, Children’s Hospital Boston, Massachusetts General Hospital and Maine Children’s Hospital) clinical trial. One hundred forty-one patients with clinical stages IIB (n=43), IIIB (n=19), IVA (n=27), and IVB (n=52) HL were treated with 12 weeks of Stanford V chemotherapy and low dose IFRT between June 2002 and May 2011. Involved nodal sites in complete remission (CR, defined as > 75% shrinkage of the original tumor and PET negative) after 8 weeks of Stanford V received 15 Gy IFRT; those sites that achieved only partial response received 25.5 Gy IFRT after completion of all 12 weeks of chemotherapy. Results: With a median follow-up of 4.6 years, the 3-year overall and event-free survival (EFS) are 97% (SE=2%) and 79% (SE=4%) respectively. There was no significant difference in EFS by stage (IIB vs. IIIB vs. IV; P=0.84). Ten patients developed progessive disease and 18 relapsed, while 5 have died (1 after relapse in an accident and 4 of refractory disease). Most common toxicities were grade 3 hematologic with 234 episodes of neutropenia in 101 patients (72%) and 85 episodes of anemia in 52 patients (37%); Fever and neutropenia occurred 13 times in 12 patients (9%). Conclusions: Risk-adapted, combined-modality therapy using 12 weeks of Stanford V chemotherapy plus IFRT is well tolerated in this population with manageable acute toxicities. Overall survival is comparable to other more intense chemotherapy regimens. Future high-risk front line therapies may consider a Stanford V backbone with targeted intensification and further tailoring of radiation therapy.

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Suicidal Attempts by Ingestion of Various Substances in 2050 Children and Adolescents in Greece

The Canadian Journal of Psychiatry ◽

10.1177/070674378903400309 ◽

1989 ◽

Vol 34 (3) ◽

pp. 205-210 ◽

Cited By ~ 3

Author(s):

Evangelos Papathomopoulos ◽

Pavlos Vlachos ◽

Demetra Kalamara ◽

Constantinos Papadatos

Keyword(s):

Children And Adolescents ◽

Early Recognition ◽

Poison Control ◽

Poison Control Center ◽

Control Center ◽

Children's Hospital ◽

Suicidal Attempts ◽

Children’S Hospital ◽

Cultural Data

This study investigates suicidal attempts by ingestion of drugs or other chemicals in 2050 children and adolescents (312 boys and 1738 girls) under seventeen years of age as seen over a six year period, 1977–1982, at the Poison Control Center, “P.A. Kyriakou” Children's Hospital, Athens, Greece. Demographic, clinical, psychosocial and cultural data were presented and discussed. It is the authors' opinion that more attention should be paid to the increased incidence of suicidal attempts in younger persons and therefore the urgent need for early recognition and prevention of this event is necessary. This is the first broad study of its kind in Greece which reflects a segment of the psycho-biosocial developments in this country.

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Screening of Depression in Overweight and Obese Children and Adolescents Presenting for Well Child Care Visits to the Children’s Hospital University of Illinois

Academic Pediatrics ◽

10.1016/j.acap.2014.05.048 ◽

2014 ◽

Vol 14 (4) ◽

pp. e12

Author(s):

Raysa C. Morales Demori ◽

Domingo Liezl ◽

Maria C. Astorga ◽

Michelle Barnes

Keyword(s):

Child Care ◽

Children And Adolescents ◽

Obese Children ◽

University Of Illinois ◽

Children's Hospital ◽

Well Child Care ◽

Children’S Hospital

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The need for tumor surveillance of children and adolescents with cancer predisposition syndromes: a retrospective cohort study in a tertiary-care children’s hospital

European Journal of Pediatrics ◽

10.1007/s00431-021-04347-x ◽

2021 ◽

Author(s):

Simon Huber ◽

Mareike Schimmel ◽

Désirée Dunstheimer ◽

Karolina Nemes ◽

Markus Richter ◽

...

Keyword(s):

Cancer Risk ◽

Children And Adolescents ◽

Current Practice ◽

Tertiary Care ◽

Cancer Predisposition ◽

Tumor Surveillance ◽

Children's Hospital ◽

Consensus Recommendations ◽

Children’S Hospital ◽

Expert Recommendations

AbstractExpert recommendations for the management of tumor surveillance in children with a variety of cancer predisposition syndromes (CPS) are available. We aimed (1) at identifying and characterizing children who are affected by a CPS and (2) at comparing current practice and consensus recommendations of the American Association for Cancer Research workshop in 2016. We performed a database search in the hospital information system of the University Children’s Hospital for CPS in children, adolescents, and young adults and complemented this by review of electronic patients’ charts. Between January 1, 2017, and December 3, 2019, 272 patients with 41 different CPS entities were identified in 20 departments (144 [52.9%] male, 128 [47.1%] female, median age 9.1 years, range, 0.4–27.8). Three (1.1%) patients died of non-malignancy-associated complications of the CPS; 49 (18.0%) patients were diagnosed with malignancy and received regular follow-up. For 209 (95.0%) of the remaining 220 patients, surveillance recommendations were available: 30/220 (13.6%) patients received CPS consultations according to existing consensus recommendations, 22/220 (10.0%) institutional surveillance approaches were not complying with recommendations, 84/220 (38.2%) patients were seen for other reasons, and 84/220 (38.2%) were not routinely cared for. Adherence to recommendations differed extensively among CPS entities.Conclusion: The spectrum of CPS patients at our tertiary-care children’s hospital is manifold. For most patients, awareness of cancer risk has to be enhanced and current practice needs to be adapted to consensus recommendations. Offering specialized CPS consultations and establishing education programs for patients, relatives, and physicians may increase adherence to recommendations. What is Known: • A wide spectrum of rare syndromes manifesting in childhood is associated with an increased cancer risk. • For many of these syndromes, expert recommendations for management and tumor surveillance are available, although based on limited evidence. What is New: • Evaluating current practice, our data attest significant shortcomings in tumor surveillance of children and adolescents with CPS even in a tertiary-care children’s hospital. • We clearly advocate a systematic and consistent integration of tumor surveillance into daily practice.

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