The Role of Mouse Mast Cell Proteases in the Proliferative Phase of Wound Healing in Microdeformational Wound Therapy

2014 ◽  
Vol 134 (3) ◽  
pp. 459-467 ◽  
Author(s):  
Julien Succar ◽  
Jeffrey Douaiher ◽  
Luca Lancerotto ◽  
Qiong Li ◽  
Ryushiro Yamaguchi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mast Cell ◽  
Wound Therapy ◽  
Proliferative Phase ◽  
Mouse Mast Cell

Experience of negative pressure wound therapy over sternal wound healing: A retrospective review

WCET Journal ◽  
2019 ◽  
Vol 39 (2) ◽  
pp. 9-18
Author(s):  
Wai Sze Ho ◽  
Wai Kuen Lee ◽  
Ka Kay Chan ◽  
Choi Ching Fong
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Assessment Tool ◽  
Wound Care ◽  
Wound Therapy ◽  
Treatment Pathways ◽  
Wound Assessment ◽  
One Year

Objectives The aim of this study was to retrospectively review the effectiveness of negative pressure wound therapy (NPWT) in sternal wound healing with the use of the validated Bates-Jensen Wound Assessment Tool (BWAT), and explore the role of NPWT over sternal wounds and future treatment pathways. Methods Data was gathered from patients' medical records and the institution's database clinical management system. Seventeen subjects, who had undergone cardiothoracic surgeries and subsequently consulted the wound care team in one year were reviewed. Fourteen of them were included in the analysis. Healing improvement of each sternal wound under continuous NPWT and continuous conventional dressings was studied. In total, 23 continuous NPWT and 13 conventional dressing episodes were analysed with the BWAT. Results Among conventional dressing episodes, sternal wound improvement was 2.5–3% over 10 days to 3.5 weeks, whereas 4–5% sternal healing was achieved in 5 days to 2 weeks with sternal wire presence. Better healing at 11% in 1 week by conventional dressing was attained after sternal wire removal. In NPWT episodes, 8–29%, 13–24%, and 15–46% of healing was observed in 2 weeks, 3.5 to 5 weeks and 6 to 7 weeks, respectively. Only 39% wound healing was acquired at the 13th week of NPWT in one subject. With sternal wire present, 6%–29% wound healing progress was achieved by NPWT in 1–4 weeks, and 16–23% wound improvement in 2 to 4.5 weeks by NWPT after further surgical debridement. After sternal wire removal, 6–34% sternal wound healing occurred by continuous NPWT for 1–2 weeks, and maximum healing at 46% after 2.5 weeks of NPWT were observed. Conclusions Better wound healing was achieved in the NPWT group in comparison to conventional dressings alone. However, suboptimal sternal wound healing by NPWT alone was observed. Removal of sternal wire may improve the effectiveness of NPWT. Successful tertiary closure after NPWT among subjects supports the important bridging role of NPWT in sternal wound healing. Factors causing stagnant sternal wound healing by NPWT alone are discussed.

The role of angiopoetic factors in wound healing among patients with diabetes treated with negative-pressure wound therapy

Leczenie Ran ◽  
2015 ◽  
Vol 11 (4) ◽  
pp. 171-178
Author(s):  
Beata Mrozikiewicz-Rakowska ◽  
Joanna Kania ◽  
Ewelina Bucior ◽  
Adriana Nowak ◽  
Tomasz Grzela ◽  
...  
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Wound Therapy ◽  
Patients With Diabetes

Pathophysiological Role of Skin Mast Cells in Wound Healing after Scald Injury: Study with Mast Cell-Deficient W/WV Mice

2010 ◽  
Vol 151 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Naotaka Shiota ◽  
Yoriko Nishikori ◽  
Eiichi Kakizoe ◽  
Keiko Shimoura ◽  
Tomomi Niibayashi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mast Cell ◽  
Mast Cells ◽  
Pathophysiological Role ◽  
Scald Injury

scholarly journals Pivotal Role of Mouse Mast Cell Protease 4 in the Conversion and Pressor Properties of Big-Endothelin-1

2013 ◽  
Vol 346 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Martin Houde ◽  
Marc-David Jamain ◽  
Julie Labonté ◽  
Louisane Desbiens ◽  
Gunnar Pejler ◽  
...  
Keyword(s):  
Mast Cell ◽  
Pivotal Role ◽  
Endothelin 1 ◽  
Mast Cell Protease ◽  
Mouse Mast Cell

scholarly journals ONE MECHANISM BEHIND LED PHOTOTHERAPY FOR WOUND HEALING AND SKIN REJUVENATION: KEY ROLE OF THE MAST CELL

LASER THERAPY ◽  
2008 ◽  
Vol 17 (3) ◽  
pp. 141-148 ◽  
Author(s):  
R Glen Calderhead ◽  
Junichiro Kubota ◽  
Mario A Trelles ◽  
Toshio Ohshiro
Keyword(s):  
Wound Healing ◽  
Mast Cell ◽  
Skin Rejuvenation ◽  
Led Phototherapy

scholarly journals The Chymase, Mouse Mast Cell Protease 4, Constitutes the Major Chymotrypsin-like Activity in Peritoneum and Ear Tissue. A Role for Mouse Mast Cell Protease 4 in Thrombin Regulation and Fibronectin Turnover

2003 ◽  
Vol 198 (3) ◽  
pp. 423-431 ◽  
Author(s):  
Elena Tchougounova ◽  
Gunnar Pejler ◽  
Magnus Åbrink
Keyword(s):  
Mast Cell ◽  
Coagulation System ◽  
Targeted Deletion ◽  
Mast Cell Protease ◽  
Mouse Mast Cell ◽  
Mast Cell Chymase ◽  
Connective Tissue Remodeling ◽  
Chymotryptic Activity ◽  
Insight Into

To gain insight into the biological role of mast cell chymase we have generated a mouse strain with a targeted deletion in the gene for mast cell protease 4 (mMCP-4), the mouse chymase that has the closest relationship to the human chymase in terms of tissue localization and functional properties. The inactivation of mMCP-4 did not affect the storage of other mast cell proteases and did not affect the number of mast cells or the mast cell morphology. However, mMCP-4 inactivation resulted in complete loss of chymotryptic activity in the peritoneum and in ear tissue, indicating that mMCP-4 is the main source of stored chymotrypsin-like protease activity at these sites. The mMCP-4 null cells showed markedly impaired ability to perform inactivating cleavages of thrombin, indicating a role for mMCP-4 in regulating the extravascular coagulation system. Further, a role for mMCP-4 in connective tissue remodeling was suggested by the inability of mMCP-4 null peritoneal cells to process endogenous fibronectin.

scholarly journals The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62

2015 ◽  
Vol 168 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Kara S. Bell ◽  
Lamyaa Al-Riyami ◽  
Felicity E. Lumb ◽  
Graham J. Britton ◽  
Alastair W. Poole ◽  
...  
Keyword(s):  
Mast Cell ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Function ◽  
Individual Protein ◽  
Kinase C ◽  
Parasitic Worm ◽  
Mouse Mast Cell ◽  
Protein Kinase C Isoforms

scholarly journals The Role of Portable Incisional Negative Pressure Wound Therapy (piNPWT) in Reducing Local Complications of Post-bariatric Brachioplasty: A Case-Control Study

2021 ◽  
Author(s):  
Federico Facchin ◽  
Andrea Pagani ◽  
Paolo Marchica ◽  
Laura Pandis ◽  
Carlotta Scarpa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Body Contouring ◽  
Full Description ◽  
Wound Therapy ◽  
Level Of Evidence ◽  
Operative Complications ◽  
Post Operative Complications

Abstract Background Due to the great impact of bariatric surgery on the overweight epidemic, the number of post-bariatric body-contouring procedures is constantly increasing worldwide. The portable incisional negative pressure wound therapy (piNPWT) is a promising medical device for accelerating wounds closure and controlling post-operative complication, which have been shown promising results in post-bariatric population. We aimed to evaluate the role of piNPWT in optimizing wound healing and controlling post-operative complications after a post-bariatric brachioplasty. Patients and Methods 26 post-bariatric female patients who underwent a brachioplasty followed by either a piNPWT (14 cases) or a standard wound treatment (12 controls) were analyzed. The number of post-operative dressing changes, the rate of local post-operative complications (re-operation, hematoma and serosa development, dehiscence and necrosis), the time to dry as well as the scar quality and hospitalization length were evaluated. Results None of the patients prematurely stopped treatment with piNPWT due to intolerance. The piNPWT patient group showed a significant lower healing time as well as a significant reduction of the number of post-operative dressing changes and hospital stay. Despite the scarring process was excellent from the functional point of view in the long term, we noticed a higher rate of hyperchromic scarring at 90 days after surgery. Conclusion The piNPWT is a cost-effective and user-friendly medical tool that increase and promote wound healing. We suggest the use of this device in post-bariatric patients who undergo a brachioplasty, especially if there is the need to minimize the number of post-operative dressing changes. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266.

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