scholarly journals Patterns and Correlates of Participant Retention in a Multi-City Pre-Exposure Prophylaxis Demonstration Project

2018 ◽  
Vol 79 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Susanne Doblecki-Lewis ◽  
Albert Y. Liu ◽  
Daniel J. Feaster ◽  
Stephanie E. Cohen ◽  
Richard Elion ◽  
...  
Keyword(s):  
Demonstration Project ◽  
Participant Retention ◽  
Exposure Prophylaxis

Predictors of Daily Adherence to HIV Pre-exposure Prophylaxis in Gay/Bisexual Men in the PRELUDE Demonstration Project

2018 ◽  
Vol 23 (5) ◽  
pp. 1287-1296 ◽  
Author(s):  
Stefanie J. Vaccher ◽  
◽  
Mark A. Marzinke ◽  
David J. Templeton ◽  
Bridget G. Haire ◽  
...  
Keyword(s):  
Demonstration Project ◽  
Bisexual Men ◽  
Exposure Prophylaxis

scholarly journals Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa

2018 ◽  
Vol 1 ◽  
pp. 3 ◽  
Author(s):  
Renee Heffron ◽  
Kenneth Ngure ◽  
Josephine Odoyo ◽  
Nulu Bulya ◽  
Edna Tindimwebwa ◽  
...  
Keyword(s):  
Hiv Infections ◽  
Hiv Treatment ◽  
Demonstration Project ◽  
Hiv Incidence ◽  
Serodiscordant Couples ◽  
Treatment Services ◽  
Hiv Serodiscordant Couples ◽  
Exposure Prophylaxis ◽  
Living With Hiv ◽  
Hiv Negative

Background: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial HIV risk.  Demonstration projects conducted in diverse settings worldwide illustrate practical examples of how PrEP can be delivered. This manuscript presents estimates of effectiveness and patterns of PrEP use within a two-year demonstration project of PrEP for HIV-negative members of heterosexual HIV serodiscordant couples in East Africa. Methods: The PrEP delivery model integrated PrEP into HIV treatment services, prioritizing PrEP use for HIV-negative partners within serodiscordant couples before and during the first 6 months after the partner living with HIV initiated antiretroviral therapy (ART).  We measured PrEP uptake through pharmacy records and adherence to PrEP through medication event monitoring system (MEMS) bottle caps and quantification of tenofovir in plasma among a random sample of participants. We estimated HIV infections prevented using a counterfactual cohort simulated from the placebo arm of a previous PrEP clinical trial. Results: We enrolled 1,010 HIV serodiscordant couples that were naïve to ART and PrEP.  Ninety-seven percent of HIV-negative partners initiated PrEP. Objective measures suggest high adherence: 71% of HIV-negative participants took ≥80% of expected doses, as recorded via MEMS, and 81% of plasma samples had tenofovir detected.  Four incident HIV infections were observed (incidence rate=0.24 per 100 person-years), a 95% reduction (95% CI 86-98%, p<0.0001) in HIV incidence, relative to estimated HIV incidence for the population in the absence of PrEP integrated into HIV treatment services.   Conclusions: PrEP uptake and adherence were high and incident HIV was rare in this PrEP demonstration project for African HIV-negative individuals whose partners were known to be living with HIV.  Delivery of PrEP to HIV-negative partners within HIV serodiscordant couples was feasible and should be prioritized for wide-scale implementation.

scholarly journals Validation of participant eligibility for pre-exposure prophylaxis: Baseline data from the PRELUDE demonstration project

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0185398 ◽  
Author(s):  
Stefanie J. Vaccher ◽  
Andrew E. Grulich ◽  
Bridget G. Haire ◽  
Damian P. Conway ◽  
Isobel M. Poynten ◽  
...  
Keyword(s):  
Baseline Data ◽  
Demonstration Project ◽  
Exposure Prophylaxis

scholarly journals Impact of Estimated Pre-Exposure Prophylaxis (PrEP) Adherence Patterns on Bone Mineral Density in a Large PrEP Demonstration Project

2019 ◽  
Vol 35 (9) ◽  
pp. 788-793 ◽  
Author(s):  
Matthew A. Spinelli ◽  
David V. Glidden ◽  
Peter L. Anderson ◽  
Monica Gandhi ◽  
Vanessa M. McMahan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Demonstration Project ◽  
Mineral Density ◽  
Exposure Prophylaxis

scholarly journals Uptake, retention, and outcomes in a demonstration project of pre-exposure prophylaxis among female sex workers in public health centers in Senegal

2020 ◽  
Vol 31 (11) ◽  
pp. 1063-1072
Author(s):  
Moussa Sarr ◽  
Daouda Gueye ◽  
Aminata Mboup ◽  
Ousmane Diouf ◽  
Mame D Bousso Bao ◽  
...  
Keyword(s):  
Sex Workers ◽  
Female Sex Workers ◽  
Retention In Care ◽  
Older Age ◽  
Demonstration Project ◽  
Retention Rates ◽  
Open Label ◽  
Female Sex ◽  
Exposure Prophylaxis

The Senegal pre-exposure prophylaxis (PrEP) Demonstration Project was an open-label cohort study assessing the delivery of daily oral PrEP to HIV-negative female sex workers (FSWs) in four Ministry of Health (MoH)-run clinics in Dakar, Senegal. We assessed uptake, retention in care, and adherence over up to 12 months of follow-up as well as HIV infection rates. Between July and November 2015, 350 individuals were approached and 324 (92.6%) were preliminarily eligible. Uptake was high, with 82.4% of eligible participants choosing to enroll and take PrEP. The mean age of those enrolled was 37.7 years (SD = 8.7), and approximately half had not attended school (41.2%). Among the 267 participants who were prescribed PrEP, 79.9 and 73.4% were retained in PrEP care at 6 and 12 months, respectively. Older age among FSWs was found to be the only significant predictor of lower discontinuation. We did not find significant differences in retention by site, education, condom use, or HIV risk perception. There were no new HIV infections at follow-up. Our results showed evidence of high interest in PrEP and very good PrEP retention rates among FSWs at 12-month follow-up when offered in MoH-run clinics, with older age as the only significant predictor of higher PrEP retention. This highlights the role that these clinics can play in expanding PrEP access nationwide.

scholarly journals Out‐of‐pocket costs and HIV pre‐exposure prophylaxis persistence in a US multicity demonstration project

2020 ◽  
Vol 55 (4) ◽  
pp. 524-530
Author(s):  
Nathan W. Furukawa ◽  
John A. Schneider ◽  
Megan E. Coleman ◽  
Jeffrey B. Wiener ◽  
Ram K. Shrestha ◽  
...  
Keyword(s):  
Demonstration Project ◽  
Exposure Prophylaxis ◽  
Out Of Pocket Costs

scholarly journals Alignment of PrEP use and effective contraceptive use among East African women in HIV serodiscordant partnerships

2020 ◽  
Vol 31 (13) ◽  
pp. 1263-1271
Author(s):  
Kenneth Ngure ◽  
Jennifer Velloza ◽  
Rena C Patel ◽  
Nelly R Mugo ◽  
Elizabeth A Bukusi ◽  
...  
Keyword(s):  
Contraceptive Use ◽  
Estimating Equation ◽  
Demonstration Project ◽  
African Women ◽  
Adjusted Relative Risk ◽  
East African ◽  
Concurrent Use ◽  
Effective Contraception ◽  
Exposure Prophylaxis ◽  
Effective Contraceptive

Women who have a prevention mindset may opt for concurrent use of oral pre-exposure prophylaxis (PrEP) and all forms of contraception; we therefore assessed how contraception may influence PrEP use or vice versa. We analyzed data from Kenyan and Ugandan HIV-uninfected non-pregnant women in sero-discordant partnerships who were participating in the Partners Demonstration Project. Using multivariable generalized estimating equation models, we estimated the associations between effective contraceptive use and 1) PrEP dispensation 2) high effective PrEP use. Among the 311 women (93.1% of all those followed in the Partners Demonstration Project) median age was 29 years (interquartile range [IQR] 24.0–35.0) and 115 (37.0%) reported using effective contraception at baseline. All the women initiated PrEP during the study and moderately high PrEP adherence was recorded at 73.1% of visits over an average 7.5 months following PrEP dispensation. Women (14.8%) consistently used an effective contraceptive throughout study follow-up. PrEP dispensation was more frequent among those concurrently using effective contraception, (adjusted relative risk [aRR] = 1.19; 95% confidence interval [CI] = 1.08–1.32) and contraceptive use was more common among those on PrEP (aRR = 1.63; 95% CI = 1.18–2.25). Among East African women at high risk of HIV infection, PrEP dispensation was more frequent among women using effective contraception, indicating that family planning outlets may be efficient locations to deliver PrEP.

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