Five years with dolutegravir plus lamivudine as a switch strategy

Background: The major endovascular mechanic thrombectomy (MT) techniques are: Stent-Retriever (SR), aspiration first pass technique (ADAPT) and Solumbra (Aspiration + SR), which are interchangeable (defined as switching strategy (SS)). The purpose of this study is to report the added value of switching from ADAPT to Solumbra in unsuccessful revascularization stroke patients. Methods: This is a retrospective, single center, pragmatic, cohort study. From December 2017 to November 2019, 935 consecutive patients were admitted to the Stroke Unit and 176/935 (18.8%) were eligible for MT. In 135/176 (76.7%) patients, ADAPT was used as the first-line strategy. SS was defined as the difference between first technique adopted and the final technique. Revascularization was evaluated with modified Thrombolysis In Cerebral Infarction (TICI) with success defined as mTICI ≥ 2b. Procedural time (PT) and time to reperfusion (TTR) were recorded. Results: Stroke involved: Anterior circulation in 121/135 (89.6%) patients and posterior circulation in 14/135 (10.4%) patients. ADAPT was the most common first-line technique vs. both SR and Solumbra (135/176 (76.7%) vs. 10/176 (5.7%) vs. 31/176 (17.6%), respectively). In 28/135 (20.7%) patients, the mTICI was ≤ 2a requiring switch to Solumbra. The vessel’s diameter positively predicted SS result (odd ratio (OR) 1.12, confidence of interval (CI) 95% 1.03–1.22; p = 0.006). The mean number of passes before SS was 2.0 ± 1.2. ADAPT to Solumbra improved successful revascularization by 13.3% (107/135 (79.3%) vs. 125/135 (92.6%)). PT was superior for SS comparing with ADAPT (71.1 min (CI 95% 53.2–109.0) vs. 40.0 min (CI 95% 35.0–45.2); p = 0.0004), although, TTR was similar (324.1 min (CI 95% 311.4–387.0) vs. 311.4 min (CI 95% 285.5–338.7); p = 0.23). Conclusion: Successful revascularization was improved by 13.3% after switching form ADAPT to Solumbra (final mTICI ≥ 2b was 92.6%). Vessel’s diameter positively predicted recourse to SS.

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One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1

Chemical Communications ◽

10.1039/c4cc00779d ◽

2014 ◽

Vol 50 (44) ◽

pp. 5837-5839 ◽

Cited By ~ 43

Author(s):

Man Pan ◽

Yao He ◽

Ming Wen ◽

Fangming Wu ◽

Demeng Sun ◽

...

Keyword(s):

Chemical Synthesis ◽

Snake Venom ◽

Structure Determination ◽

Native Chemical Ligation ◽

One Pot ◽

Chemical Ligation ◽

Venom Toxin ◽

Snake Venom Toxin ◽

Switch Strategy

An efficient one-pot chemical synthesis of snake venom toxin Mambalgin-1 was achieved using an azide-switch strategy combined with hydrazide-based native chemical ligation.

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Flexible Switch Strategy for the Limited-Cycle with Multiple Periods

Innovation and Supply Chain Management ◽

10.14327/iscm.7.168 ◽

2013 ◽

Vol 7 (4) ◽

pp. 168-173

Author(s):

Jing SUN ◽

Xianda KONG ◽

Hisashi YAMAMOTO ◽

Masayuki MATSUI

Keyword(s):

Switch Strategy

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Responses to Modified Monty Hall Dilemmas in Capuchin Monkeys, Rhesus Macaques, and Humans

International Journal of Comparative Psychology ◽

10.46867/ijcp.2018.31.03.06 ◽

2018 ◽

Vol 31 ◽

Author(s):

Julia Watzek ◽

Will Whitham ◽

David A. Washburn ◽

Sarah F. Brosnan

Keyword(s):

Decision Making ◽

Rhesus Macaques ◽

The Other ◽

Comparative Approach ◽

Capuchin Monkeys ◽

Monty Hall Dilemma ◽

Decision Making Processes ◽

Monty Hall ◽

Text Version ◽

Switch Strategy

The Monty Hall Dilemma (MHD) is a simple probability puzzle famous for its counterintuitive solution. Participants initially choose among three doors, one of which conceals a prize. A different door is opened and shown not to contain the prize. Participants are then asked whether they would like to stay with their original choice or switch to the other remaining door. Although switching doubles the chances of winning, people overwhelmingly choose to stay with their original choice. To assess how experience and the chance of winning affect decisions in the MHD, we used a comparative approach to test 264 college students, 24 capuchin monkeys, and 7 rhesus macaques on a nonverbal, computerized version of the game. Participants repeatedly experienced the outcome of their choices and we varied the chance of winning by changing the number of doors (three or eight). All species quickly and consistently switched doors, especially in the eight-door condition. After the computer task, we presented humans with the classic text version of the MHD to test whether they would generalize the successful switch strategy from the computer task. Instead, participants showed their characteristic tendency to stick with their pick, regardless of the number of doors. This disconnect between strategies in the classic version and a repeated nonverbal task with the same underlying probabilities may arise because they evoke different decision-making processes, such as explicit reasoning versus implicit learning.

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