scholarly journals Uptake, Retention, and Adherence to Pre-exposure Prophylaxis (PrEP) in TRIUMPH: A Peer-Led PrEP Demonstration Project for Transgender Communities in Oakland and Sacramento, California

2021 ◽  
Vol 88 (S1) ◽  
pp. S27-S38
Author(s):  
Jae M. Sevelius ◽  
David V. Glidden ◽  
Madeline Deutsch ◽  
Layla Welborn ◽  
Alejandro Contreras ◽  
...  
Keyword(s):  
Demonstration Project ◽  
Exposure Prophylaxis

Predictors of Daily Adherence to HIV Pre-exposure Prophylaxis in Gay/Bisexual Men in the PRELUDE Demonstration Project

2018 ◽  
Vol 23 (5) ◽  
pp. 1287-1296 ◽  
Author(s):  
Stefanie J. Vaccher ◽  
◽  
Mark A. Marzinke ◽  
David J. Templeton ◽  
Bridget G. Haire ◽  
...  
Keyword(s):  
Demonstration Project ◽  
Bisexual Men ◽  
Exposure Prophylaxis

scholarly journals Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa

2018 ◽  
Vol 1 ◽  
pp. 3 ◽  
Author(s):  
Renee Heffron ◽  
Kenneth Ngure ◽  
Josephine Odoyo ◽  
Nulu Bulya ◽  
Edna Tindimwebwa ◽  
...  
Keyword(s):  
Hiv Infections ◽  
Hiv Treatment ◽  
Demonstration Project ◽  
Hiv Incidence ◽  
Serodiscordant Couples ◽  
Treatment Services ◽  
Hiv Serodiscordant Couples ◽  
Exposure Prophylaxis ◽  
Living With Hiv ◽  
Hiv Negative

Background: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial HIV risk.  Demonstration projects conducted in diverse settings worldwide illustrate practical examples of how PrEP can be delivered. This manuscript presents estimates of effectiveness and patterns of PrEP use within a two-year demonstration project of PrEP for HIV-negative members of heterosexual HIV serodiscordant couples in East Africa. Methods: The PrEP delivery model integrated PrEP into HIV treatment services, prioritizing PrEP use for HIV-negative partners within serodiscordant couples before and during the first 6 months after the partner living with HIV initiated antiretroviral therapy (ART).  We measured PrEP uptake through pharmacy records and adherence to PrEP through medication event monitoring system (MEMS) bottle caps and quantification of tenofovir in plasma among a random sample of participants. We estimated HIV infections prevented using a counterfactual cohort simulated from the placebo arm of a previous PrEP clinical trial. Results: We enrolled 1,010 HIV serodiscordant couples that were naïve to ART and PrEP.  Ninety-seven percent of HIV-negative partners initiated PrEP. Objective measures suggest high adherence: 71% of HIV-negative participants took ≥80% of expected doses, as recorded via MEMS, and 81% of plasma samples had tenofovir detected.  Four incident HIV infections were observed (incidence rate=0.24 per 100 person-years), a 95% reduction (95% CI 86-98%, p<0.0001) in HIV incidence, relative to estimated HIV incidence for the population in the absence of PrEP integrated into HIV treatment services.   Conclusions: PrEP uptake and adherence were high and incident HIV was rare in this PrEP demonstration project for African HIV-negative individuals whose partners were known to be living with HIV.  Delivery of PrEP to HIV-negative partners within HIV serodiscordant couples was feasible and should be prioritized for wide-scale implementation.

scholarly journals Changes in mental health and drug use among men who have sex with men using daily and event-driven pre-exposure prophylaxis: Results from a prospective demonstration project in Amsterdam, the Netherlands

2020 ◽  
Vol 26 ◽  
pp. 100505
Author(s):  
R.C.A. Achterbergh ◽  
E. Hoornenborg ◽  
A. Boyd ◽  
L. Coyer ◽  
S.J.A. Meuzelaar ◽  
...  
Keyword(s):  
Mental Health ◽  
Drug Use ◽  
The Netherlands ◽  
Demonstration Project ◽  
Event Driven ◽  
Sex With Men ◽  
Exposure Prophylaxis

scholarly journals Patterns and Correlates of Participant Retention in a Multi-City Pre-Exposure Prophylaxis Demonstration Project

2018 ◽  
Vol 79 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Susanne Doblecki-Lewis ◽  
Albert Y. Liu ◽  
Daniel J. Feaster ◽  
Stephanie E. Cohen ◽  
Richard Elion ◽  
...  
Keyword(s):  
Demonstration Project ◽  
Participant Retention ◽  
Exposure Prophylaxis

scholarly journals High pre-exposure prophylaxis uptake and early adherence among men who have sex with men and transgender women at risk for HIV Infection: the PrEP Brasil demonstration project

2017 ◽  
Vol 20 (1) ◽  
pp. 21472 ◽  
Author(s):  
Brenda Hoagland ◽  
Ronaldo I. Moreira ◽  
Raquel B. De Boni ◽  
Esper G. Kallas ◽  
José Valdez Madruga ◽  
...  
Keyword(s):  
At Risk ◽  
Hiv Infection ◽  
Transgender Women ◽  
Demonstration Project ◽  
Sex With Men ◽  
Exposure Prophylaxis

scholarly journals Validation of participant eligibility for pre-exposure prophylaxis: Baseline data from the PRELUDE demonstration project

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0185398 ◽  
Author(s):  
Stefanie J. Vaccher ◽  
Andrew E. Grulich ◽  
Bridget G. Haire ◽  
Damian P. Conway ◽  
Isobel M. Poynten ◽  
...  
Keyword(s):  
Baseline Data ◽  
Demonstration Project ◽  
Exposure Prophylaxis

scholarly journals Impact of Estimated Pre-Exposure Prophylaxis (PrEP) Adherence Patterns on Bone Mineral Density in a Large PrEP Demonstration Project

2019 ◽  
Vol 35 (9) ◽  
pp. 788-793 ◽  
Author(s):  
Matthew A. Spinelli ◽  
David V. Glidden ◽  
Peter L. Anderson ◽  
Monica Gandhi ◽  
Vanessa M. McMahan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Demonstration Project ◽  
Mineral Density ◽  
Exposure Prophylaxis

scholarly journals Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa

2017 ◽  
Vol 1 ◽  
pp. 3 ◽  
Author(s):  
Renee Heffron ◽  
Kenneth Ngure ◽  
Josephine Odoyo ◽  
Nulu Bulya ◽  
Edna Tindimwebwa ◽  
...  
Keyword(s):  
Hiv Infections ◽  
Hiv Treatment ◽  
Demonstration Project ◽  
Open Label ◽  
Serodiscordant Couples ◽  
Treatment Services ◽  
Hiv Serodiscordant Couples ◽  
Exposure Prophylaxis ◽  
Living With Hiv ◽  
Hiv Negative

Introduction: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial HIV risk, such as individuals with a partner living with HIV.  Demonstration projects of PrEP have been conducted in diverse settings worldwide to illustrate practical examples of how PrEP can be delivered.  Methods: We evaluated delivery of PrEP for HIV-negative partners within heterosexual HIV serodiscordant couples in an open-label demonstration project in East Africa.  The delivery model integrated PrEP into HIV treatment services, prioritizing PrEP for HIV-negative partners within serodiscordant couples prior to and during the first 6 months after the partner living with HIV initiated antiretroviral therapy (ART).  We measured adherence to PrEP through medication event monitoring system (MEMS) bottle caps and quantification of tenofovir in plasma among a random sample of participants. We estimated HIV infections prevented using a counterfactual cohort simulated from the placebo arm of a previous PrEP clinical trial. Results: We enrolled 1,010 HIV serodiscordant couples that were naïve to ART and PrEP.  Ninety-seven percent (97%) of HIV-negative partners initiated PrEP, and when PrEP was dispensed, objective measures suggest high adherence: 71% of HIV-negative participants took ≥80% of expected doses, as recorded via MEMS, and 81% of plasma samples had tenofovir detected.  A total of 4 incident HIV infections were observed (incidence rate=0.24 per 100 person-years), a 95% reduction (95% CI 86-98%, p<0.0001) in HIV incidence, relative to estimated HIV incidence for the population in the absence of PrEP integrated into HIV treatment services.   Conclusions: PrEP uptake and adherence were high and incident HIV was rare in this PrEP demonstration project for African HIV-negative individuals whose partners were known to be living with HIV.  Delivery of PrEP to HIV-negative partners within HIV serodiscordant couples was feasible and should be prioritized for wide-scale implementation.

scholarly journals Uptake, retention, and outcomes in a demonstration project of pre-exposure prophylaxis among female sex workers in public health centers in Senegal

2020 ◽  
Vol 31 (11) ◽  
pp. 1063-1072
Author(s):  
Moussa Sarr ◽  
Daouda Gueye ◽  
Aminata Mboup ◽  
Ousmane Diouf ◽  
Mame D Bousso Bao ◽  
...  
Keyword(s):  
Sex Workers ◽  
Female Sex Workers ◽  
Retention In Care ◽  
Older Age ◽  
Demonstration Project ◽  
Retention Rates ◽  
Open Label ◽  
Female Sex ◽  
Exposure Prophylaxis

The Senegal pre-exposure prophylaxis (PrEP) Demonstration Project was an open-label cohort study assessing the delivery of daily oral PrEP to HIV-negative female sex workers (FSWs) in four Ministry of Health (MoH)-run clinics in Dakar, Senegal. We assessed uptake, retention in care, and adherence over up to 12 months of follow-up as well as HIV infection rates. Between July and November 2015, 350 individuals were approached and 324 (92.6%) were preliminarily eligible. Uptake was high, with 82.4% of eligible participants choosing to enroll and take PrEP. The mean age of those enrolled was 37.7 years (SD = 8.7), and approximately half had not attended school (41.2%). Among the 267 participants who were prescribed PrEP, 79.9 and 73.4% were retained in PrEP care at 6 and 12 months, respectively. Older age among FSWs was found to be the only significant predictor of lower discontinuation. We did not find significant differences in retention by site, education, condom use, or HIV risk perception. There were no new HIV infections at follow-up. Our results showed evidence of high interest in PrEP and very good PrEP retention rates among FSWs at 12-month follow-up when offered in MoH-run clinics, with older age as the only significant predictor of higher PrEP retention. This highlights the role that these clinics can play in expanding PrEP access nationwide.

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