MRI Changes of the Symphysis Pubis in Patients With Axial Spondyloarthritis and Association With Clinical Factors

ObjectiveTo investigate the frequency of bone marrow oedema (BME) and fatty lesions (FL) suggestive of axial spondyloarthritis (axSpA) on MRI of the spine and sacroiliac joints (SIJ) in a general population sample.MethodsAs part of a community-based cohort project (Study of Health in Pomerania), volunteers underwent spinal (sagittal T1/T2) and SIJ (semicoronal short tau inversion recovery) MRI examinations. Two calibrated readers evaluated the images to detect BME in SIJ and vertebral corners (VC) and FL in VC suggestive of axSpA using Assessment of SpondyloArthritis international Society definitions.ResultsMRIs of 793 volunteers (49.4% males, mean age 37.3±6.3 years, 8.4% human leucocyte antigen-B27+) aged <45 years were evaluated. SIJ BME was seen in 136 (17.2%), VC BME in 218 (27.5%) and FL in 645 (81.4%) volunteers. SIJ BME in ≥1, ≥3 and ≥5 SIJ quadrants was seen in 136 (17.2%), 7 (0.9%) and 1 (0.1%) volunteers, respectively. In VC, BME≥1, ≥3 and ≥5 lesions were seen in 218 (27.5%), 38 (4.8%) and 6 (0.8%) volunteers, respectively, while FL≥1, ≥3 and ≥5 were seen in 645 (81.3%), 351 (44.3%) and 185 (23.3%) volunteers, respectively. Logistic regression analysis showed that BME and FL in VC were related to increasing age: OR 1.33, 95% CI 1.02 to 1.72, and OR 1.73, 95% CI 1.32 to 2.27, per decade increase, respectively.ConclusionsIn this large population-based study, a high frequency of inflammatory and fatty MRI lesions suggestive of axSpA was found, especially in the spine. This indicates a limited value of such MRI findings for diagnosis and classification of axSpA. The increasing frequency with age suggests that mechanical factors could play a role.

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Ankylosing spondylitis and non-radiographic axial spondyloarthritis: Two stages of disease?

Terapevticheskii arkhiv ◽

10.17116/terarkh201789533-37 ◽

2017 ◽

Vol 89 (5) ◽

pp. 33-37 ◽

Cited By ~ 8

Author(s):

D G Rumyantseva ◽

T V Dubinina ◽

A B Demina ◽

O A Rumyantseva ◽

E M Agafonova ◽

...

Keyword(s):

Ankylosing Spondylitis ◽

Disease Duration ◽

Axial Spondyloarthritis ◽

Early Stage ◽

Clinical Manifestations ◽

The Mean ◽

Magnetic Resonance Imaging Mri ◽

Mri Changes ◽

Two Stages

Aim. To compare the clinical manifestations of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrAxSpA). Subjects and methods. A Moscow early spondyloarthritis cohort has now included 132 patients with axial spondyloarthritis, of whom 69 patients who have been followed up at least 12 months are to be involved in a preliminary analysis. The mean age at the time of inclusion in the study was 28.1±5.5 years; the mean disease duration was 24.7±15.8 months; 63 (91.3%) patients were HLA-B27 positive; 41 and 28 included patients were diagnosed with AS and nrAxSpA, respectively. Results. Men were significantly more in the AS group than in the nrAxSpA group (58.5 and 32.1%, respectively; p=0.05). The patients of the two groups did not differ in main clinical parameters (the presence of arthritis and enthesitis), disease activity (BASDAI, ASDAS-CRP) and functional status (BASFI). All indicators of inflammatory activity decreased nearly 2-fold in both groups after 12 months of follow up. In 7 (25%) patients with nrAxSpA, radiologically detectable sacroiliitis (SI) developed over 12 months and the diagnosis of AS was verified. Among them, 2 (28.5%) patients had initially active SI detected by magnetic resonance imaging (MRI); 4 (57.1%) had chronic SI, and 1 (14.4%) had no pathological MRI changes. Conclusion. Due to the fact that the clinical manifestations of AS and nrAxSpA are comparable, it can be assumed that the latter is an early stage of AS.

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Frequency of MRI changes suggestive of axial spondyloarthritis in the axial skeleton in a large population-based cohort of individuals aged <45 years

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2019-216773 ◽

2019 ◽

pp. annrheumdis-2019-216773

Author(s):

Konstantinos Parperis

Keyword(s):

Axial Spondyloarthritis ◽

Large Population ◽

Axial Skeleton ◽

Population Based ◽

Mri Changes

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Response to: ‘Frequency of MRI changes suggestive of axial spondyloarthritis in the axial in a large population-based cohort of individuals aged <45 years’ by Parperis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2019-216798 ◽

2020 ◽

pp. annrheumdis-2019-216798

Author(s):

Xenofon Baraliakos ◽

Adrian Richter ◽

Carsten O Schmidt ◽

Juergen Braun

Keyword(s):

Axial Spondyloarthritis ◽

Large Population ◽

Population Based ◽

Mri Changes

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Clinical Factors May Predict Fracture Risk Better Than FRAX

Internal Medicine News ◽

10.1016/s1097-8690(08)71251-4 ◽

2008 ◽

Vol 41 (22) ◽

pp. 25

Author(s):

JEFF EVANS

Keyword(s):

Fracture Risk ◽

Clinical Factors ◽

Predict Fracture Risk ◽

Better Than

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The Reliability of Retrieval-Induced Forgetting

European Psychologist ◽

10.1027/1016-9040/a000040 ◽

2012 ◽

Vol 17 (1) ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Rosalind Potts ◽

Robin Law ◽

John F. Golding ◽

David Groome

Keyword(s):

Individual Differences ◽

Recognition Test ◽

Laboratory Tests ◽

The Other ◽

Clinical Factors ◽

Test Items ◽

T1 And T2 ◽

Test Materials ◽

Induced Forgetting

Retrieval-induced forgetting (RIF) refers to the finding that the retrieval of an item from memory impairs the retrieval of related items. The extent to which this impairment is found in laboratory tests varies between individuals, and recent studies have reported an association between individual differences in the strength of the RIF effect and other cognitive and clinical factors. The present study investigated the reliability of these individual differences in the RIF effect. A RIF task was administered to the same individuals on two occasions (sessions T1 and T2), one week apart. For Experiments 1 and 2 the final retrieval test at each session made use of a category-cue procedure, whereas Experiment 3 employed category-plus-letter cues, and Experiment 4 used a recognition test. In Experiment 2 the same test items that were studied, practiced, and tested at T1 were also studied, practiced, and tested at T2, but for the remaining three experiments two different item sets were used at T1 and T2. A significant RIF effect was found in all four experiments. A significant correlation was found between RIF scores at T1 and T2 in Experiment 2, but for the other three experiments the correlations between RIF scores at T1 and T2 failed to reach significance. This study therefore failed to find clear evidence for reliable individual differences in RIF performance, except where the same test materials were used for both test sessions. These findings have important implications for studies involving individual differences in RIF performance.

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