Low-Contrast Agent Dose Dual-Energy CT Monochromatic Imaging in Pulmonary Angiography Versus Routine CT

2013 ◽  
Vol 37 (4) ◽  
pp. 618-625 ◽  
Author(s):  
Jian Dong ◽  
Xiaoying Wang ◽  
Xuexiang Jiang ◽  
Li Gao ◽  
Feiyu Li ◽  
...  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kai Scherer ◽  
Johannes Hammel ◽  
Thorsten Sellerer ◽  
Korbinian Mechlem ◽  
Bernhard Renger ◽  
...  

Abstract Ischemic heart disease is the globally leading cause of death. When using coronary CT angiography, the functional hemodynamics within the myocardium remain uncertain. In this study myocardial CT perfusion imaging using iodine contrast agent demonstrated to strongly improve the assessment of myocardial disorders. However, a retrieval of such dynamics using Hounsfield units from conventional CT poses concerns with respect to beam-hardening effects and low contrast-to-noise ratio (CNR). Dual-energy CT offers novel approaches to overcome aforementioned limitations. Quantitative peak enhancement, perfusion, time to peak and iodine volume measurements inside the myocardium were determined resulting in 0.92 mg/ml, 0.085 mg/ml/s 17.12 s and 29.89 mg/ml*s, respectively. We report on the first extensive quantitative and iodine-based analysis of myocardial dynamics in a healthy porcine model using a dual-layer spectral CT. We further elucidate on the potential of reducing the radiation dose from 135 to 18 mGy and the contrast agent volume from 60 to 30 mL by presenting a two-shot acquisition approach and measuring iodine concentrations in the myocardium in-vivo down to 1 mg/ml, respectively. We believe that dynamic quantitative iodine perfusion imaging may be a highly sensitive tool for the precise functional assessment and monitoring of early myocardial ischemia.


2020 ◽  
Vol 27 (5) ◽  
pp. e116-e122 ◽  
Author(s):  
Morikatsu Yoshida ◽  
Takeshi Nakaura ◽  
Takada Sentaro ◽  
Shota Tanoue ◽  
Hatsuki Inada ◽  
...  

2011 ◽  
Vol 79 (2) ◽  
pp. e11-e17 ◽  
Author(s):  
Myrna C.B. Godoy ◽  
Samantha L. Heller ◽  
David P. Naidich ◽  
Bernard Assadourian ◽  
Christianne Leidecker ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167214 ◽  
Author(s):  
Andreas Meier ◽  
Kai Higashigaito ◽  
Katharina Martini ◽  
Moritz Wurnig ◽  
Burkhardt Seifert ◽  
...  

2014 ◽  
Vol 22 (5) ◽  
pp. 689-696 ◽  
Author(s):  
Jie Liu ◽  
Pei-Jie Lv ◽  
Runze Wu ◽  
Yong-Gao Zhang ◽  
Li-Li Hu ◽  
...  

2020 ◽  
Vol 2 (5) ◽  
pp. e200428 ◽  
Author(s):  
Carole A Ridge ◽  
Sujal R Desai ◽  
Nidhish Jeyin ◽  
Ciara Mahon ◽  
Dione L Lother ◽  
...  

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