scholarly journals First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

2017 ◽  
Vol 52 (7) ◽  
pp. 419-427 ◽  
Author(s):  
Martijn Smeenge ◽  
François Tranquart ◽  
Christophe K. Mannaerts ◽  
Theo M. de Reijke ◽  
Marc J. van de Vijver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Ultrasound Molecular Imaging ◽  
Molecular Contrast

scholarly journals Real Time Ultrasound Molecular Imaging of Prostate Cancer with PSMA-targeted Nanobubbles

2019 ◽  
Author(s):  
Reshani Perera ◽  
Al de Leon ◽  
Xinning Wang ◽  
Yu Wang ◽  
Gopal Ramamurthy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Real Time ◽  
Sensitivity And Specificity ◽  
Cancer Detection ◽  
Contrast Enhanced ◽  
Ultrasound Molecular Imaging ◽  
Tumor Accumulation ◽  
Specific Membrane

AbstractContrast-enhanced ultrasound with microbubbles has shown promise in detection of prostate cancer (PCa), but sensitivity and specificity of detection remain challenging. Targeted nanoscale contrast agents with improved capability to accumulate in tumors may result in prolonged signal enhancement and improved detection of PCa with ultrasound. Here we report on a new nanobubble contrast agent that specifically targets prostate specific membrane antigen (PSMA) overexpressed in most prostate tumors. The PSMA-targeted bubbles (PSMA-NB) were utilized to simultaneously image dual flank PCa tumors (PSMA-positive PC3pip and PSMA-negative PC3flu) to examine whether the biomarker can be successfully detected and imaged using this probe in a mouse model. Results demonstrate that active targeting of NBs to PSMA rapidly and selectively enhances tumor accumulation and is critical for tumor retention of the contrast agent. Importantly, these processes could be visualized and quantified, in real time, with standard clinical ultrasound. Such demonstration of the immense yet underutilized potential of ultrasound in the area of molecular imaging can open the door to future opportunities for improving sensitivity and specificity of cancer detection using parametric NB-enhanced ultrasound imaging.

scholarly journals Ultrasound Molecular Imaging of Tumor Angiogenesis With an Integrin Targeted Microbubble Contrast Agent

2011 ◽  
Vol 46 (4) ◽  
pp. 215-224 ◽  
Author(s):  
Christopher R. Anderson ◽  
Xiaowen Hu ◽  
Hua Zhang ◽  
Jose Tlaxca ◽  
Anne-Emilie Declèves ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Microbubble Contrast Agent ◽  
Ultrasound Molecular Imaging

Quantitative ultrasound molecular imaging by modeling the binding kinetics of targeted contrast agent

2017 ◽  
Vol 62 (6) ◽  
pp. 2449-2464 ◽  
Author(s):  
Simona Turco ◽  
Isabelle Tardy ◽  
Peter Frinking ◽  
Hessel Wijkstra ◽  
Massimo Mischi
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Quantitative Ultrasound ◽  
Binding Kinetics ◽  
Ultrasound Molecular Imaging ◽  
Kinetics Of ◽  
Targeted Contrast Agent

scholarly journals A stimulus-responsive contrast agent for ultrasound molecular imaging

Biomaterials ◽  
2008 ◽  
Vol 29 (5) ◽  
pp. 597-606 ◽  
Author(s):  
Mark A. Borden ◽  
Hua Zhang ◽  
Robert J. Gillies ◽  
Paul A. Dayton ◽  
Katherine W. Ferrara
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Stimulus Responsive ◽  
Ultrasound Molecular Imaging

scholarly journals Real time ultrasound molecular imaging of prostate cancer with PSMA-targeted nanobubbles

2020 ◽  
Vol 28 ◽  
pp. 102213 ◽  
Author(s):  
Reshani H. Perera ◽  
Al de Leon ◽  
Xinning Wang ◽  
Yu Wang ◽  
Gopal Ramamurthy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Real Time ◽  
Ultrasound Molecular Imaging
Sign in / Sign up

Export Citation Format

Share Document