F-18 Fluoride PET/CT in the Detection of Radiation-Induced Pelvic Insufficiency Fractures

2011 ◽  
Vol 36 (10) ◽  
pp. e146-e149 ◽  
Author(s):  
Sumeet G. Dua ◽  
Nilendu C. Purandare ◽  
Sneha Shah ◽  
Venkatesh Rangarajan
Keyword(s):  
Insufficiency Fractures ◽  
Pet Ct ◽  
Radiation Induced

scholarly journals Impact of [18F]FDG-PET and [18F]FLT-PET-Parameters in Patients with Suspected Relapse of Irradiated Lung Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 279
Author(s):  
Tine N. Christensen ◽  
Seppo W. Langer ◽  
Gitte Persson ◽  
Klaus Richter Larsen ◽  
Annemarie G. Amtoft ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Fdg Pet ◽  
Tumor Volume ◽  
High Dose ◽  
Flt Pet ◽  
Pet Ct ◽  
Radiation Induced ◽  
Fdg Pet Ct ◽  
Induced Changes

Radiation-induced changes may cause a non-malignant high 2-deoxy-2-[18F]fluoro-d-glucose (FDG)-uptake. The 3′-deoxy-3′-[18F]fluorothymidine (FLT)-PET/CT performs better in the differential diagnosis of inflammatory changes and lung lesions with a higher specificity than FDG-PET/CT. We investigated the association between post-radiotherapy FDG-PET-parameters, FLT-PET-parameters, and outcome. Sixty-one patients suspected for having a relapse after definitive radiotherapy for lung cancer were included. All the patients had FDG-PET/CT and FLT-PET/CT. FDG-PET- and FLT-PET-parameters were collected from within the irradiated high-dose volume (HDV) and from recurrent pulmonary lesions. For associations between PET-parameters and relapse status, respectively, the overall survival was analyzed. Thirty patients had a relapse, of these, 16 patients had a relapse within the HDV. FDG-SUVmax and FLT-SUVmax were higher in relapsed HDVs compared with non-relapsed HDVs (median FDG-SUVmax: 12.8 vs. 4.2; p < 0.001; median FLT-SUVmax 3.9 vs. 2.2; p < 0.001). A relapse within HDV had higher FDG-SUVpeak (median FDG-SUVpeak: 7.1 vs. 3.5; p = 0.014) and was larger (median metabolic tumor volume (MTV50%): 2.5 vs. 0.7; 0.014) than the relapsed lesions outside of HDV. The proliferative tumor volume (PTV50%) was prognostic for the overall survival (hazard ratio: 1.07 pr cm3 [1.01–1.13]; p = 0.014) in the univariate analysis, but not in the multivariate analysis. FDG-SUVmax and FLT-SUVmax may be helpful tools for differentiating the relapse from radiation-induced changes, however, they should not be used definitively for relapse detection.

scholarly journals Radiation-induced insufficiency fractures of the pelvis: evaluation with 99mTc-methylene diphosphonate scintigraphy.

1992 ◽  
Vol 158 (3) ◽  
pp. 599-602 ◽  
Author(s):  
H Abe ◽  
M Nakamura ◽  
S Takahashi ◽  
S Maruoka ◽  
Y Ogawa ◽  
...  
Keyword(s):  
Insufficiency Fractures ◽  
Methylene Diphosphonate ◽  
Radiation Induced

Radiation-induced liver injury mimicking liver metastases on FDG-PET-CT after chemoradiotherapy for esophageal cancer

2017 ◽  
Vol 194 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Francine E. M. Voncken ◽  
Berthe M. P. Aleman ◽  
Jolanda M. van Dieren ◽  
Cecile Grootscholten ◽  
Ferry Lalezari ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Liver Injury ◽  
Liver Metastases ◽  
Fdg Pet ◽  
Pet Ct ◽  
Radiation Induced ◽  
Fdg Pet Ct

scholarly journals Radiation Therapy Planning of Thoracic Tumors: A Review of Challenges Associated With Lung Toxicities and Potential Perspectives of Gallium-68 Lung PET/CT Imaging

2021 ◽  
Vol 8 ◽  
Author(s):  
François Lucia ◽  
Martin Rehn ◽  
Frédérique Blanc-Béguin ◽  
Pierre-Yves Le Roux
Keyword(s):  
Radiation Therapy ◽  
Lung Function ◽  
Lung Injury ◽  
Ct Imaging ◽  
Therapy Planning ◽  
Significant Treatment ◽  
Radiation Therapy Planning ◽  
Pet Ct ◽  
Thoracic Radiation ◽  
Radiation Induced

Despite the introduction of new radiotherapy techniques, such as intensity modulated radiation therapy or stereotactic body radiation therapy, radiation induced lung injury remains a significant treatment related adverse event of thoracic radiation therapy. Functional lung avoidance radiation therapy is an emerging concept in the treatment of lung disease to better preserve lung function and to reduce pulmonary toxicity. While conventional ventilation/perfusion (V/Q) lung scintigraphy is limited by a relatively low spatial and temporal resolution, the recent advent of 68Gallium V/Q lung PET/CT imaging offers a potential to increase the accuracy of lung functional mapping and to better tailor lung radiation therapy plans to the individual's lung function. Lung PET/CT imaging may also improve our understanding of radiation induced lung injury compared to the current anatomical based dose–volume constraints. In this review, recent advances in radiation therapy for the management of primary and secondary lung tumors and in V/Q PET/CT imaging for the assessment of functional lung volumes are reviewed. The new opportunities and challenges arising from the integration of V/Q PET/CT imaging in radiation therapy planning are also discussed.

scholarly journals Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab

Medicina ◽  
2020 ◽  
Vol 56 (4) ◽  
pp. 155
Author(s):  
Lukas Šalaševičius ◽  
Goda Elizabeta Vaitkevičienė ◽  
Ramunė Pasaulienė ◽  
Rosita Kiudelienė ◽  
Ernesta Ivanauskaitė-Didžiokienė ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Correct Diagnosis ◽  
Secondary Malignancy ◽  
Drug Resistant ◽  
Classic Hodgkin Lymphoma ◽  
Pet Ct ◽  
Radiation Induced ◽  
Early Radiation ◽  
Tumor Biopsies ◽  
Pet Ct Scan

Radiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivolumab) of a relapsed classic Hodgkin lymphoma (HL) and was diagnosed post-mortem. The patient died of the progressive RIS that was misleadingly assumed to be a resistant HL based on the positive PET/CT scan. Repetitive tumor biopsies are warranted in cases of aggressive and multi-drug resistant HL to validate imaging findings, ensure correct diagnosis and avoid overtreatment.

scholarly journals DNA Damage in Blood Leukocytes of Prostate Cancer Patients Undergoing PET/CT Examinations with [68Ga]Ga-PSMA I&T

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 388 ◽  
Author(s):  
Sarah Schumann ◽  
Harry Scherthan ◽  
Torsten Frank ◽  
Constantin Lapa ◽  
Jessica Müller ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ex Vivo ◽  
Absorbed Dose ◽  
Dna Double Strand Breaks ◽  
Blood Leukocytes ◽  
Blood Samples ◽  
Time Points ◽  
Pet Ct ◽  
Radiation Induced

The aim was to investigate the induction and repair of radiation-induced DNA double-strand breaks (DSBs) as a function of the absorbed dose to the blood of patients undergoing PET/CT examinations with [68Ga]Ga-PSMA. Blood samples were collected from 15 patients before and at four time points after [68Ga]Ga-PSMA administration, both before and after the PET/CT scan. Absorbed doses to the blood were calculated. In addition, blood samples with/without contrast agent from five volunteers were irradiated ex vivo by CT while measuring the absorbed dose. Leukocytes were isolated, fixed, and stained for co-localizing γ-H2AX+53BP1 DSB foci that were enumerated manually. In vivo, a significant increase in γ-H2AX+53BP1 foci compared to baseline was observed at all time points after administration, although the absorbed dose to the blood by 68Ga was below 4 mGy. Ex vivo, the increase in radiation-induced foci depended on the absorbed dose and the presence of contrast agent, which could have caused a dose enhancement. The CT-dose contribution for the patients was estimated at about 12 mGy using the ex vivo calibration. The additional number of DSB foci induced by CT, however, was comparable to the one induced by 68Ga. The significantly increased foci numbers after [68Ga]Ga-PSMA administration may suggest a possible low-dose hypersensitivity.

scholarly journals R-CHOP-Associated Graves’ Hyperthyroidism

2019 ◽  
Vol 12 (2) ◽  
pp. 581-588 ◽  
Author(s):  
Natalie Mora ◽  
Katherine N. Vu ◽  
Thanh D. Hoang ◽  
Vinh Q. Mai ◽  
Mohamed K.M. Shakir
Keyword(s):  
Thyroid Dysfunction ◽  
B Cell Lymphoma ◽  
Laboratory Evaluation ◽  
Graves Disease ◽  
Thyroid Mass ◽  
Pet Ct ◽  
Patient Reported ◽  
Persistent Fatigue ◽  
Radiation Induced ◽  
Oncologic Treatment

Radiation-induced thyroid dysfunction following oncologic treatment is not uncommon, however limited literature data has been found on patients that underwent chemotherapy only. A change in thyrometabolic autoimmune status is also a rare entity. We present a case of newly diagnosed Graves’ thyrotoxicosis following a successful R-CHOP (Rituximab, Cyclophosphamide, Doxorubicine, Vincristine and Prednisone) treatment in a patient with concurrent abdominal and thyroid diffuse large B-cell lymphoma (DLBCL). Following chemotherapy, PET CT showed resolution of FDG-avid thyroid nodule as well as no evidence of the thyroid mass on repeat ultrasound. Her thyroid function also normalized. During her follow-up visit, patient reported significant unintentional weight loss and persistent fatigue over the past couple months. Repeat laboratory evaluation revealed TSH 0.005 mIU/mL, FT4 6.73 ng/dL and thyroid stimulating immunoglobulin (TSI) 535 (ref <140%). She was started on methimazole followed by radioactive iodine therapy. This unique case of Graves’ disease following R-CHOP treatment in patients with known Hashimoto’s and thyroid lymphoma is one of the first to be reported in the literature. The swing of pendulum from Hashimoto’s to Graves’ disease is very uncommon. As clinicians, we need to continue monitoring for clinical and biochemical thyroid dysfunction in this subset of population.

scholarly journals 3D bone texture analysis as a potential predictor of radiation-induced insufficiency fractures

2018 ◽  
Vol 8 (1) ◽  
pp. 14-24 ◽  
Author(s):  
Valerio Nardone ◽  
Paolo Tini ◽  
Stefania Croci ◽  
Salvatore Francesco Carbone ◽  
Lucio Sebaste ◽  
...  
Keyword(s):  
Texture Analysis ◽  
Insufficiency Fractures ◽  
Potential Predictor ◽  
Radiation Induced ◽  
Bone Texture Analysis

Radiation-induced sarcoma after radiotherapy for breast cancer in a 18F-FDG PET/CT study

2020 ◽  
Vol 39 (2) ◽  
pp. 100-101
Author(s):  
A. Martínez-Esteve ◽  
M. Moreno-Caballero ◽  
P. Jiménez-Granero ◽  
A. Cobo-Rodríguez ◽  
J.I. Rayo-Madrid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Pet Ct ◽  
Radiation Induced ◽  
18F Fdg ◽  
Fdg Pet Ct
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