Fabrication of Poly(L-Lactic Acid)/Chitosan Scaffolds by Solid–Liquid Phase Separation Method for Nerve Tissue Engineering

2019 ◽  
Vol 30 (3) ◽  
pp. 784-789 ◽  
Author(s):  
Majid Salehi ◽  
Saeed Farzamfar ◽  
Shaghayegh Bozorgzadeh ◽  
Farshid Bastami
2021 ◽  
Vol 22 (7) ◽  
pp. 3536
Author(s):  
Hongyun Xuan ◽  
Biyun Li ◽  
Feng Xiong ◽  
Shuyuan Wu ◽  
Zhuojun Zhang ◽  
...  

Despite the existence of many attempts at nerve tissue engineering, there is no ideal strategy to date for effectively treating defective peripheral nerve tissue. In the present study, well-aligned poly (L-lactic acid) (PLLA) nanofibers with varied nano-porous surface structures were designed within different ambient humidity levels using the stable jet electrospinning (SJES) technique. Nanofibers have the capacity to inhibit bacterial adhesion, especially with respect to Staphylococcus aureus (S. aureus). It was noteworthy to find that the large nano-porous fibers were less detrimentally affected by S. aureus than smaller fibers. Large nano-pores furthermore proved more conducive to the proliferation and differentiation of neural stem cells (NSCs), while small nano-pores were more beneficial to NSC migration. Thus, this study concluded that well-aligned fibers with varied nano-porous surface structures could reduce bacterial colonization and enhance cellular responses, which could be used as promising material in tissue engineering, especially for neuro-regeneration.


2012 ◽  
Vol 291 (5) ◽  
pp. 1293-1296 ◽  
Author(s):  
Zhimei Wei ◽  
Quanchao Zhang ◽  
Lihua Wang ◽  
Xiaojun Wang ◽  
Shengru Long ◽  
...  

2016 ◽  
Vol 12 (1) ◽  
pp. 015008 ◽  
Author(s):  
Ena Bolaina-Lorenzo ◽  
Cristina Martínez-Ramos ◽  
Manuel Monleón-Pradas ◽  
Wilberth Herrera-Kao ◽  
Juan V Cauich-Rodríguez ◽  
...  

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